Abstract: Objective：To evaluate the effect and safety of propofol target controlled infusion (TCI) with a small dosage of fentanyl intravenous sedation on the removal of the third impacted molar tooth. Methods: In the study, 58 ASA (American Society of Anesthesiology) Ⅰ-Ⅱ patients with impacted wisdom tooth removal (age: 18-45 years), were divided into two groups: control group (n=26) received 40 mg lidocaine+propofol TCI; experimental group (n=32) received 0.8 μg/kg fentanyl+propofol TCI. The complete evaluating indexes were recorded, and the data compared and analyzed. Results: The differences of the gender, age, weight, operation time and sedation time were not significant. The heart rate and bispectral index of the experimental group on local anesthesia injection were significantly lower than those of the control group (P<0.05). Other differences on heart rate, mean blood pressure, pulse oxygen saturation, respiration rate and bispectral index between the two groups were not significant during operation. The differences on recall of local anesthesia injection, incision and drilling between the two groups were not significant. The pain caused by the propofol injection, and the body movement caused by local anesthesia injection and talkativeness during operation in the experimental group were significantly lower than those in the control group (P<0.05). No patient in the two groups had nausea and vomiting. After discharge, 19 patients in the experimental group (19/32), 14 patients in the control group (14/26) were sleepy after coming home. The difference of the patient’s satisfaction between the two group was not significant, but the patient’s satisfaction was significantly higher than the doctor’s (P<0.05), and the doctor’s satisfaction in the experimental group was significantly higher than that in the control group (P<0.05). Conclusion: Propofol TCI with a small dosage of fentanyl intravenous sedation on the removal of impacted wisdom tooth is effective and safe. Both patients and doctors have high degree of satisfaction on it.

Key words: Molar, third, Tooth extraction, Anesthesia, intravenous, Propofol, Fentanyl