Journal of Peking University (Health Sciences) ›› 2020, Vol. 52 ›› Issue (2): 247-253. doi: 10.19723/j.issn.1671-167X.2020.02.009
Previous Articles Next Articles
Liang GENG1,Jing LV2,△(),Jing FAN3
CLC Number:
[1] | 陈璐, 高威 . 肿瘤酸性微环境的形成机制及其对肿瘤进展的影响[J]. 肿瘤, 2019,39(2):140-145. |
[2] | Li X, Yu X, Dai D , et al. The altered glucose metabolism in tumor and a tumor acidic microenvironment associated with extracellular matrix metalloproteinase inducer and monocarboxylate transporters[J]. Oncotarget, 2016,7(17):23141-23155. |
[3] | Wojtkowiak JW, Verduzco D, Schramm KJ , et al. Drug resistance and cellular adaptation to tumor acidic pH microenvironment[J]. Mol Pharm, 2011,8(6):2032-2038. |
[4] | 龚巍 . 调节性T细胞和胃癌的临床与实验研究[D]. 苏州: 苏州大学, 2017. |
[5] | Fukumura D, Jain RK . Tumor microvasculature and microenvironment: Targets for anti-angiogenesis and normalization[J]. Microvasc Res, 2007,74(2-3):72-84. |
[6] | Ganapathy V, Thangaraju M, Prasad PD . Nutrient transporters in cancer: Relevance to Warburg hypojournal and beyond[J]. Pharmacol Ther, 2009,121(1):29-40. |
[7] | Seagroves TN, Ryan HE, Lu H , et al. Transcription factor HIF-1 is a necessary mediator of the Pasteur effect in mammalian cells[J]. Mol Cell Biol, 2001,21(10):3436-3444. |
[8] | Semenza GL . Targeting HIF-1 for cancer therapy[J]. Nat Rev Cancer, 2003,3(10):721-732. |
[9] | Lee JW, Bae SH, Jeong JW , et al. Hypoxia-inducible factor (HIF-1) alpha: Its protein stability and biological functions[J]. Exp Mol Med, 2004,36(1):1-12. |
[10] | Winum JY, Rami M, Scozzafava A , et al. Carbonic anhydrase Ⅸ: A new druggable target for the design of antitumor agents[J]. Med Res Rev, 2008,28(3):445-463. |
[11] | van den Beucken T, Ramaekers CH, Rouschop K , et al. Deficient carbonic anhydrase 9 expression in UPR-impaired cells is associated with reduced survival in an acidic microenvironment[J]. Radiother Oncol, 2009,92(3):437-442. |
[12] | Verras M, Papandreou I, Lim AL , et al. Tumor hypoxia blocks Wnt processing and secretion through the induction of endoplasmic reticulum stress[J]. Mol Cell Biol, 2008,28(23):7212-7224. |
[13] | 张翔云, 周华妙, 郭勇 . 黄连解毒汤等对乳腺癌荷瘤小鼠肿瘤酸性微环境pH值的影响[J]. 黑龙江中医药, 2016,45(4):64-65. |
[14] | Flinck M, Kramer SH, Pedersen SF . Roles of pH in control of cell proliferation[J]. Acta Physiol (Oxf), 2018,223(3):e13068. |
[15] | Peppicelli S, Andreucci E, Ruzzolini J . The acidic microenvironment as a possible niche of dormant tumor cells[J]. Cell Mol Life Sci, 2017,74(15):2761-2771. |
[16] | Ryder C , McColl K,Zhong F, et al.Acidosis promotes Bcl-2 family-mediated evasion of apoptosis: Involvement of acid-sensing G protein-coupled receptor Gpr65 signaling to Mek/Erk[J]. J Biol Chem, 2012,287(33):27863-27867. |
[17] | Dhup S, Dadhich RK, Porporato PE , et al. Multiple biological activities of lactic acid in cancer: Influences on tumor growth, angiogenesis and metastasis[J]. Curr Pharm Des, 2012,18(10):1319-1330. |
[1] | Xiaodong CHAI,Ziwen SUN,Haishuang LI,Liangyi ZHU,Xiaodan LIU,Yantao LIU,Fei PEI,Qing CHANG. Clinicopathological characteristics of the CD8+ T lymphocytes infiltration and its mechanism in distinct molecular subtype of medulloblastoma [J]. Journal of Peking University (Health Sciences), 2024, 56(3): 512-518. |
[2] | Yun-chong LIU,Zong-long WU,Li-yuan GE,Tan DU,Ya-qian WU,Yi-meng SONG,Cheng LIU,Lu-lin MA. Mechanism of nuclear protein 1 in the resistance to axitinib in clear cell renal cell carcinoma [J]. Journal of Peking University (Health Sciences), 2023, 55(5): 781-792. |
[3] | Jing LIU,Ai-dong LU,Ying-xi ZUO,Jun WU,Zhi-zhuo HUANG,Yue-ping JIA,Ming-ming DING,Le-ping ZHANG,Jiong QIN. Clinical characteristics and prognosis of seizures in 75 children with acute lymphoblastic leukemia [J]. Journal of Peking University (Health Sciences), 2022, 54(5): 948-953. |
[4] | GU Yang-chun,LIU Ying,XIE Chao,CAO Bao-shan. Pituitary immune-related adverse events induced by programmed cell death protein 1 inhibitors in advanced lung cancer patients: A report of 3 cases [J]. Journal of Peking University (Health Sciences), 2022, 54(2): 369-375. |
[5] | LOU Xue,LIAO Li,LI Xing-jun,WANG Nan,LIU Shuang,CUI Ruo-mei,XU Jian. Methylation status and expression of TWEAK gene promoter region in peripheral blood of patients with rheumatoid arthritis [J]. Journal of Peking University (Health Sciences), 2021, 53(6): 1020-1025. |
[6] | GAO Ya-dong,ZHU An,LI Lu-di,ZHANG Tao,WANG Shuo,SHAN Dan-ping,LI Ying-zi,WANG Qi. Cytotoxicity and underlying mechanism of evodiamine in HepG2 cells [J]. Journal of Peking University (Health Sciences), 2021, 53(6): 1107-1114. |
[7] | LIAO Xu-he,WANG Rong-fu,LIU Meng,CHEN Xue-qi,XIONG Yan,NONG Lin,YIN Lei,ZHANG Bing-ye,DU Yu-jing. Semiquantitative parameters of 18F-FDG PET/CT, gene mutation states of epidermal growth factor receptor and anaplastic lymphoma kinase in prognosis evaluation of patients with lung adenocarcinoma [J]. Journal of Peking University (Health Sciences), 2021, 53(2): 246-254. |
[8] | Lei-zhen SU,Jie CHEN,Xian LI,Ping JI. Effects of salinomycin on proliferation and apoptosis of oral squamous cell carcinoma [J]. Journal of Peking University (Health Sciences), 2020, 52(5): 902-906. |
[9] | Yi BAO,Juan-fen MO. Concordant point mutation of ETS-related gene (ERG) in tumor tissues from a synchronous multiple primary lung cancer: A case report [J]. Journal of Peking University (Health Sciences), 2020, 52(5): 971-974. |
[10] | Zhi-wei SUN,Jun JIA,Ying YANG,Chuan-ling LIU,Yan-jie XIAO,Jing YU,Xiao-dong ZHANG. Enteral nutrition support reduces toxicity of chemotherapy in patients with advanced or metastatic esophageal cancer [J]. Journal of Peking University (Health Sciences), 2020, 52(2): 261-268. |
[11] | Yi-xiang MA,Jing-wei LIU,Kang QI,Ji-xin ZHANG,Gang LIN,Hai-bo LIU,Xue-qian SHANG,Jian LI. Diagnosis and treatment of seven primary mediastinal yolk sac tumors [J]. Journal of Peking University(Health Sciences), 2019, 51(6): 1091-1095. |
[12] | LI Man, LI Yuan, SUN Lin, SONG Jun-lai, LV Cong. High mobility group box 1 promotes apoptosis of astrocytes after oxygen glucose deprivation/reoxygenation by regulating the expression of Bcl-2 and Bax [J]. Journal of Peking University(Health Sciences), 2018, 50(5): 785-791. |
[13] | SUN Jing, SONG Wei-dong, YAN Si-yuan, XI Zhi-jun. Chloroquine inhibits viability of renal carcinoma cells and enhances sunitinib-induced caspase-dependent apoptosis [J]. Journal of Peking University(Health Sciences), 2018, 50(5): 778-784. |
[14] | WANG Hao, CHEN Liang, YE Xiao-yun. Triptolide induces oxidative stress and apoptosis and activates PIK3/Akt signaling pathway in TM4 sertoli cells [J]. Journal of Peking University(Health Sciences), 2018, 50(4): 607-612. |
[15] | MEI Fang, ZHAO Ting-ting, GAO Fei, ZHENG Jie. A rare pulmonary benign bi-phasic tumor: a case report of pulmonary adenofibroma and literature review [J]. Journal of Peking University(Health Sciences), 2017, 49(6): 1076-1080. |
|