北京大学学报(医学版) ›› 2014, Vol. 46 ›› Issue (5): 744-750.

• 论著 • 上一篇    下一篇

借助磁共振成像可定位的Eudragit-E液体栓塞剂的制备及性质

柳盈盈1,卢晓静1,郑卓肇2,关海涛3,付乃奇2,吕天石3,张水生3,宋莉3,邹英华3,范田园1△   

  1. (1. 北京大学药学院药剂学系,北京100191;2. 北京大学第三医院放射科,北京100191;3. 北京大学第一医院介入血管外科,北京100034)
  • 出版日期:2014-10-18 发布日期:2014-10-18

Preparation and investigation of MRI-traceable Eudragit-E liquid embolic agent

LIU Ying-ying1, LU Xiao-jing1, ZHENG Zhuo-zhao2, GUAN Hai-tao3, FU Nai-qi2, LV Tian-shi 3, ZHANG Shui-sheng3, SONG Li3, ZOU Ying-hua3, FAN Tian-yuan1△   

  1. (1. Department of Pharmaceutics, Peking University School of Pharmaceutical Sciences, Beijing 100191, China; 2. Department of Radiology, Peking University Third Hospital, Beijing 100191, China; 3. Department of Interventional Radiology and Vascular Surgery, Peking University First Hospital, Beijing 100034, China)
  • Online:2014-10-18 Published:2014-10-18

摘要: 目的:研究借助磁共振成像(magnetic resonance imaging,MRI)可定位的EudragitE液体栓塞剂(MR-E)的制备方法,并对其体外和体内的性质进行研究。方法:采用化学共沉淀法制备聚乙二醇修饰的超顺磁性氧化铁(polyethylene glycol-modified superparamagnetic iron oxides,PEG-SPIO),将PEG-SPIO和Eudragit-E液体栓塞剂混合均匀制得MR-E。通过体外MRI实验考察MR-E的成像性质,并筛选PEG-SPIO的浓度。通过经微导管推注实验和体外固化实验考察MR-E的推注性能和固化性质。以家兔肾动脉为栓塞模型,考察MR-E的体内栓塞效果和磁共振成像性质。结果:MR-E中PEG-SPIO的浓度确定为2 g/L,MR-E具有良好的推注性能和固化性质,0.2 mL MR-E注入家兔肾动脉后,可以有效地栓塞肾动脉远端血管,并且通过MRI可以示踪MR-E的组织分布情况。结论:MR-E有望成为一种新型的借助MRI可定位的液体栓塞剂。

关键词: 栓塞, 治疗性, 液体栓塞剂, 磁共振成像, 氧化铁

Abstract: Objective:To develop and investigate the properties of MRI-traceable Eudragit-E liquid embolic agent (MR-E). Methods: Polyethylene glycol-modified superparamagnetic iron oxides (PEG-SPIO) was synthesized by chemical co-precipitation method. MR-E was prepared by mixing PEG-SPIO and Eudragit-E liquid embolic agent homogeneously. An in vitro MR phantom study was carried out to measure MR traceability of MR-E and to determine the concentration of PEG-SPIO for further studies. The microcatheter deliverability and sol-gel transition process of MR-E were investigated. MR-E was injected into the kidney of a Japanese white big ear rabbit via an angiographic microcatheter, and detected by MRI. Results: A PEG-SPIO concentration of 2 g/L was considered to be suitable for further studies. MR-E was injected through the microcatheter without any difficulty. MR-E instantly solidified on release into saline. Then 0.2 mL of MR-E effectively embolized distal renal arteries, and MR-E could be detected by MRI in the embolized kidney. Conclusion: MR-E seems to be a promising MRI-traceable liquid embolic agent.

Key words: Embolization,therapeutic, Liquid embolic agent, Magnetic resonance imaging, Ferric oxide

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