北京大学学报(医学版) ›› 2015, Vol. 47 ›› Issue (2): 302-304. doi: 10.3969/j.issn.1671-167X.2015.02.022

• 论著 • 上一篇    下一篇

椎基底动脉延长扩张症的计算流体力学分析

韩金涛1,乔惠婷2,韩旭3,李选1△,和清源4,叶珊5,栾景源1,王昌明1,董国祥1   

  1. (1. 北京大学第三医院介入血管外科,北京100191;2. 北京航空航天大学生物与医学工程学院, 北京100191;3. 中国核电工程有限公司,北京100840;4. 北京大学第三医院放射科,北京100191;5. 北京大学第三医院神经内科,北京100191)
  • 出版日期:2015-04-18 发布日期:2015-04-18

Analysis of vertebrobasilar dolichoectasia based on computational fluid dynamics

HAN Jin-tao1, QIAO Hui-ting2, HAN Xu3, LI Xuan1△, HE Qing-yuan4, YE Shan5, LUAN Jing-yuan1, WANG Chang-ming1 , DONG Guo-xiang1   

  1. (1. Interventional Radiology and Vascular Surgery Department, Peking University Third Hospital, Beijing 100191, China;2. Biological and Medical Engineering, Beijing University of Aeronautics and Astronautics,Beijing 100191, China;3. China Nuclear Power Engineering Co.Ltd,Beijing 100840, China; 4. Department of Radiology, Peking University Third Hospital, Beijing 100191, China; 5. Department of Neurology,Peking University Third Hospital, Beijing 100191, China)
  • Online:2015-04-18 Published:2015-04-18

摘要: 目的:基于计算流体力学(computational fluid dynamics,CFD)技术对椎基底动脉延长扩张症(vertebrobasilar dolichoectasia,VBD)进行血流动力学分析。方法:使用Mimics软件读取1例VBD患者颅内动脉影像的DICOM(digital imaging and communications in medicine)数据,进行三维实体重建,应用Ansys软件对实体模型进行流体力学分析,模拟VBD患者椎基底动脉的血流动力学变化过程,并描述流线、管壁切应力和管壁压力情况。结果: 双侧椎动脉汇合为基底动脉后血流仍表现为分层流动,在基底动脉迂曲部出现绕壁血流。椎基底动脉汇合部及基底动脉下段的局部低壁面切应力和高壁面压力区域相吻合。推测VBD的生长初始部位可能位于椎基底动脉汇合部及基底动脉下段,低壁面切应力导致的血管壁退化及相应区域存在的高壁面压力可能与VBD的发生、发展有关。结论:CFD数值仿真可能为进一步研究血流动力学在VBD发生、发展中的作用提供理论基础。

关键词: 椎基底动脉供血不足, 计算流体力学, 血流动力学

Abstract: Objective: To anslysis the hemodynamic states of vertebrobasilar dolichoectasia based on computational fluid dynamics technique. Methods: The original DICOM format image data from a patient with vertebrobasilar dolichoectasia (VBD), were imported by the Mimics software directly,and the 3D Objects were constructed.The simulation of model was made with Ansys software, the hemodynamic parameters such as streamlines, wall shear stress(WSS) and wall pressure were described. Results: There was stable laminar flow in proximal basilar artery and was no blood flow mixed by bilateral vertebral artery.However, Spiral flows were appeared in distal tortuous basilar artery. The low WSS regions in the vertebrabasilar junction section and inferior segment of basilar artery were coincide with the high wall pressure regions.It could be speculated the initial growth regions might be located in the vertebrabasilar junction section and inferior segment of basilar artery.Local regions with low WSS and high wall pressure might be associated with the occurrence and development of VBD. Conclusion: CFD numerical simulation maybe can provide a theoretical basis for the role of hemodynamic factors in occurrence and development of VBD.

Key words: Vertebrobasilar insufficiency, Hydrodynamics, Hemodynamics

中图分类号: 

  • R743.31
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