北京大学学报(医学版) ›› 2023, Vol. 55 ›› Issue (6): 1144-1148. doi: 10.19723/j.issn.1671-167X.2023.06.030

• 短篇论著 • 上一篇    

p16/Ki67细胞学双染在子宫颈癌前病变及宫颈癌筛查中的应用

李辉1,彭敏2,武娇1,张青霞3,宁博涵3,董颖3,*()   

  1. 1 内蒙古巴彦淖尔市中医医院病理科, 内蒙古临河 015000
    2 内蒙古巴彦淖尔市中医医院妇产科, 内蒙古临河 015000
    3 北京大学第一医院病理科, 北京 100034
  • 收稿日期:2022-09-30 出版日期:2023-12-18 发布日期:2023-12-11
  • 通讯作者: 董颖 E-mail:dongying_999@163.com
  • 基金资助:
    内蒙古自治区关键技术攻关计划项目(2021GG0283)

辉 李1,敏 彭2,娇 武1,青霞 张3,博涵 宁3,颖 董3,*()   

  • Received:2022-09-30 Online:2023-12-18 Published:2023-12-11
  • Contact: 颖 董 E-mail:dongying_999@163.com
  • Supported by:
    the Key Technology Research Plan Project of Inner Mongolia Autonomous Region(2021GG0283)

RICH HTML

  

关键词: 宫颈液基细胞学, p16/Ki67细胞学双染, 人乳头瘤病毒

中图分类号: 

  • R361.2

图1

子宫颈脱落上皮细胞p16/Ki67免疫细胞化学双染,胞质呈棕色且胞核呈红色(箭头所示, ×400)"

图2

p16/Ki67免疫细胞化学双染阳性相对应的组织学HE染色(×200)"

图3

子宫颈脱落上皮细胞p16/Ki67免疫细胞化学双染假阴性(×400)"

图4

p16/Ki67免疫细胞化学双染假阴性相对应的组织学HE染色(×200)"

图5

p16/Ki67免疫细胞化学双染假阴性相对应的Ki67免疫组织化学染色(×200)"

图6

p16/Ki67免疫细胞化学双染假阴性相对应的p16免疫组织化学染色(×200)"

1 Shen HP , Hsiao YH , Yang SF , et al. Single nucleotide polymorphisms and haplotypes of carbonic anhydrase 9 can predict invasive squamous cell carcinoma of uterine cervix[J]. Int J Med Sci, 2018, 15 (6): 587- 594.
doi: 10.7150/ijms.23359
2 梁江红, 罗蕊丽. p16/Ki67细胞学双染检测对宫颈癌筛查患者的分流管理现状[J]. 湖北医药学院学报, 2016, 35 (2): 228- 230.
doi: 10.13819/j.issn.1006-9674.2016.02.029
3 Renshaw AA , Deschenes M , Auger M . ASC/SIL Ratio for cytotechnologists a surrogate marker of screening sensitivity[J]. Am J Clin Pathol, 2009, 131 (6): 776- 781.
doi: 10.1309/AJCPXANG59GPHJNU
4 Origoni M , Carminati G , Sideri M , et al. "Low-grade positivity" of HPV viral load after atypical squamous cells of undetermined significance (ASC-US) cytology identifies women at low-risk for cervical intraepithelial neoplasia grade 2 and 3[J]. Eur J Gynaecol Oncol, 2011, 33 (3): 261- 264.
5 Schmidt D , Bergeron C , Denton KJ , et al. p16 /ki-67 dual-stain cytology in the triage of ASCUS and LSIL Papanicolaou cytology: Results from the European equivocal or mildly abnormal Papanicolaou cytology study[J]. Cancer Cytopathol, 2011, 119 (3): 158- 166.
doi: 10.1002/cncy.20140
6 潘秦镜. TBS子宫颈细胞学报告系统回顾及新版解读[J]. 中国妇产科临床杂志, 2017, 18 (1): 95- 96.
7 Yu LL , Chen W , Lei XQ , et al. Evaluation of p16/Ki-67 dual staining in detection of cervical precancer and cancers: A multicenter study in China[J]. Oncotarget, 2016, 7 (16): 21181- 21189.
doi: 10.18632/oncotarget.8307
8 卢珊珊, 沈丹华. 第5版WHO女性生殖器官肿瘤分类的更新及解读[J]. 中华妇产科杂志, 2021, 56 (8): 588- 592.
doi: 10.3760/cma.j.cn112141-20210518-00273
9 Pi X , Wang L , Chen S . Application of p16/Ki-67 dual-staining cytology in cervical cancers[J]. J Cancer, 2019, 10 (12): 2654- 2660.
doi: 10.7150/jca.32743
10 Cheng JX , Yao LL , Xiang H , et al. Cervical cytology ASCUS patients with HPV detection and clinical value[J]. Clin Exp Obstet Gynecol, 2016, 43 (4): 592- 596.
doi: 10.12891/ceog3100.2016
11 Prigenzi KCK , Heinke T , Salim RC , et al. Dual p16 and Ki-67 expression in liquid-based cervical cytological samples compared to pap cytology findings, biopsies, and HPV testing in cervical can-cer screening: A diagnostic accuracy study[J]. Acta Cytol, 2018, 62 (2): 104- 114.
doi: 10.1159/000487504
12 张颖. 122例意义不明确宫颈不典型鳞状上皮细胞(ASCUS)的临床分析[J]. 中国医药指南, 2016, 14 (3): 65- 66.
13 Li Y , Liu J , Gong L , et al. Combining HPV DNA load with p16/Ki-67staining to detect cervical precancerous lesions and predict the progression of CIN1-2 lesions[J]. Virol J, 2019, 16 (1): 117.
doi: 10.1186/s12985-019-1225-6
14 Clarke MA , Cheung LC , Castle PE , et al. Five-year risk of cervical precancer following p16/Ki-67 dual-stain triage of HPV-positive women[J]. JAMA Oncol, 2019, 5 (2): 181- 186.
doi: 10.1001/jamaoncol.2018.4270
15 Areán-Cuns C , Mercado-Gutiérrez M , Paniello-Alastruey I , et al. Dual staining for p16/Ki67 is a more specific test than cytology for triage of HPV-positive women[J]. Virchows Arch, 2018, 473 (5): 599- 606.
16 Benevolo M , Mancuso P , Allia E , et al. Interlaboratory concor-dance of p16/Ki-67 dual-staining interpretation in HPV-positive women in a screening population[J]. Cancer Cytopathol, 2020, 128 (5): 323- 332.
doi: 10.1002/cncy.22248
17 徐海沧, 胡沙沙, 耿守孟, 等. p16/Ki-67双染在宫颈癌筛查分流中的应用价值[J]. 诊断病理学杂志, 2022, 29 (7): 614- 619.
[1] 周传香,周正,张晔,刘晓筱,高岩. 28例口腔基底样鳞状细胞癌的临床病理分析[J]. 北京大学学报(医学版), 2022, 54(1): 62-67.
[2] 梁凌云*, 杜辉*, 王纯, 张薇, 陈芸, 渠新风, 杨斌, 吴波, 吴若松, Jerome L. Belinson, 吴瑞芳. 深圳人群人乳头瘤病毒感染亚型分布与宫颈上皮内瘤变现况横断面调查[J]. 北京大学学报(医学版), 2013, 45(1): 114-118.
[3] 郭艳利, 耿力, 游珂, 乔杰, 刘从容. 外阴和阴道上皮内瘤变的临床初步研究[J]. 北京大学学报(医学版), 2009, 41(5): 561-564.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!