口腔黏膜嗜酸性溃疡的临床病理分析

doi:10.19723/j.issn.1671-167X.2025.03.030

北京大学学报（医学版） ›› 2025, Vol. 57 ›› Issue (3): 620-625. doi: 10.19723/j.issn.1671-167X.2025.03.030

• 短篇论著 • 上一篇

口腔黏膜嗜酸性溃疡的临床病理分析

朱慧¹, 闵赛南¹, 苏家增¹, 陈艳², 彭歆¹, 于尧¹, 俞光岩¹^,*()

¹ 北京大学口腔医学院·口腔医院口腔颌面外科, 国家口腔医学中心, 国家口腔疾病临床医学研究中心, 口腔生物材料和数字诊疗装备国家工程研究中心, 口腔数字医学北京市重点实验室, 国家卫生健康委员会口腔医学计算机应用工程技术研究中心, 北京 100081
² 北京大学口腔医学院·口腔医院病理科, 国家口腔医学中心, 国家口腔疾病临床医学研究中心, 口腔生物材料和数字诊疗装备国家工程研究中心, 口腔数字医学北京市重点实验室, 国家卫生健康委员会口腔医学计算机应用工程技术研究中心, 北京 100081

收稿日期:2024-02-05 出版日期:2025-06-18 发布日期:2025-06-13
通讯作者: 俞光岩

朱慧¹, 闵赛南¹, 苏家增¹, 陈艳², 彭歆¹, 于尧¹, 俞光岩¹^,*()

Received:2024-02-05 Online:2025-06-18 Published:2025-06-13
Contact: 俞光岩

摘要/Abstract

中图分类号:

R781.5

朱慧, 闵赛南, 苏家增, 陈艳, 彭歆, 于尧, 俞光岩. 口腔黏膜嗜酸性溃疡的临床病理分析[J]. 北京大学学报（医学版）, 2025, 57(3): 620-625.

朱慧, 闵赛南, 苏家增, 陈艳, 彭歆, 于尧, 俞光岩. [J]. Journal of Peking University (Health Sciences), 2025, 57(3): 620-625.

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参考文献 22

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6	Melgarejo Moreno PJ , Hellín Meseguer D , Ruiz Macía JA . Eosinophilic ulcers of the tongue as an adverse reaction to carbamazepine[J]. An Otorrinolaringol Ibero Am, 1998, 25 (2): 167- 171.
7	el-Mofty SK , Swanson PE , Wick MR , et al. Eosinophilic ulcer of the oral mucosa.Report of 38 new cases with immunohistochemical observations[J]. Oral Surg Oral Med Oral Pathol, 1993, 75 (6): 716- 722. doi: 10.1016/0030-4220(93)90429-8
8	Dash S , Sarkar N , Sethy M , et al. An ulcer on the tongue of a child[J]. Pediatr Dermatol, 2023, 40 (6): 1130- 1132. doi: 10.1111/pde.15332
9	Rakocz M , Frand M , Brand N . Familial dysautonomia with RigaFede's disease: Report of case[J]. ASDC J Dent Child, 1987, 54 (1): 57- 59.
10	Hamie L , Hamie M , Kurban M , et al. Eosinophilic ulcer of the oral mucosa: An update on clinicopathologic features, pathogenesis, and management[J]. Int J Dermatol, 2022, 61 (11): 1359- 1363. doi: 10.1111/ijd.15986
11	Vélez A , Alamillos FJ , Dean A , et al. Eosinophilic ulcer of the oral mucosa: Report of a recurrent case on the tongue[J]. Clin Exp Dermatol, 1997, 22 (3): 154- 156. doi: 10.1111/j.1365-2230.1997.tb01047.x
12	Rosa DE , Hapid MH , Hidayat W . Non-healing chronic traumatic ulcer, an entity that can resemble other chronic ulcers[J]. Int Med Case Rep J, 2023, 16, 585- 590.
13	Lee CC , Yu KH , Chan TM . Kimura's disease: A clinicopathological study of 23 cases[J]. Front Med(Lausanne), 2022, 9, 1069102.
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15	Almoznino G , Zini A , Mizrahi Y , et al. Elevated serum IgE in recurrent aphthous stomatitis and associations with disease characteristics[J]. Oral Dis, 2014, 20 (4): 386- 394. doi: 10.1111/odi.12131
16	Criado PR , Miot HA , Ianhez M . Eosinophilia and elevated IgE serum levels: A red flag: When your diagnosis is not a common atopic eczema or common allergy[J]. Inflamm Res, 2023, 72 (3): 541- 551. doi: 10.1007/s00011-023-01690-7
17	Capodiferro S , Tempesta A , Limongelli L , et al. Primary orofacial manifestations of langerhans cell histiocytosis in pediatric age: A bi-institutional retrospective study on 45 cases[J]. Children(Basel), 2020, 7 (9): 104.
18	Nguyen T , Yaghsezian A , Lin YL , et al. An unusual case of cluster of differentiation 30-positive T-cell lymphoproliferative disorder manifesting as mandibular gingival ulceration: A case report[J]. J Am Dent Assoc, 2022, 153 (2): 175- 182.
19	Benitez B , Mülli J , Tzankov A , et al. Traumatic ulcerative granuloma with stromal eosinophilia-clinical case report, literature review, and differential diagnosis[J]. World J Surg Oncol, 2019, 17 (1): 184.
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Case	Gender	Age/years	Duration/weeks	Location	Range/(cm×cm)	Etiology	EO(×10⁹/L)	Clinical impression	Management	Follow-up/months	Recurrence	Times of other ulcers^*
1	M	30	1	The dorsum of the tongue	2.0×1.5	Stab	1.66↑	Malignant tumor？	Resection	12	No	3
2	F	60	12	Lateral margin of the tongue	1.5×1.0	Psychological	0.03	Malignant tumor	Biopsy	24	No	2
3	M	10	4	Buccal mucosa	2.0×2.0	None	-	Malignant tumor	Biopsy	66	No	0
4	F	57	2	Lateral margin of the tongue	1.5×1.0	None	-	Malignant tumor	Biopsy	54	No	0
5	M	0.5	8	The belly of the tongue	1.5×1.0	Incisor rubbing	0.85↑	Tumor？	Resection	42	No	4
6	M	49	1.5	Lateral margin of the tongue	4.0×3.0	Bite	0.07	Tumor or infection？	Biopsy	11	No	0

口腔黏膜嗜酸性溃疡的临床病理分析

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