目的: 评估隐形矫治在重度牙周炎伴前牙区病理性移位患者中的临床疗效。方法: 回顾性分析2019—2022年在北京大学口腔医院牙周科和正畸科同时就诊的重度牙周炎伴前牙区病理性移位的患者共26例，患者定期进行牙周基础治疗并维护，均采用隐形矫治器进行正畸治疗，利用软件测量口腔扫描数据，比较正畸前后病理性移位患牙的咬合分布和邻面接触评分，同时评价牙周治疗前和正畸治疗前后牙周临床指标的变化。结果: 26例患者病理性移位的前牙共217颗，其中105颗在牙周治疗前存在探诊深度(probing depth, PD)≥ 5 mm的牙周袋。隐形矫治后，咬合评分由10.35±8.61提高至23.62± 9.73(P < 0.001)，邻面接触评分由13.62±4.73提升至31.62± 10.37(P < 0.001)。牙周治疗前(T0)，患牙的平均PD中位数为3.33 mm [四分位距(interquartile range, IQR)=0.92]；正畸治疗前(T1)，PD降至2.50 mm (IQR=0.67，P < 0.001)；隐形矫治后(T2)，PD仍维持在2.50 mm (IQR=0.50)，与T0相比差异有统计学意义(P < 0.001)，T1与T2之间差异无统计学意义(P=0.948)。结论: 隐形矫治对重度牙周炎伴前牙区病理性移位的患者具有良好的临床疗效，未来需要更多大样本量的前瞻性对照研究进一步验证其长期临床效果。

Objective: To evaluate the clinical efficacy of clear aligner therapy in patients with severe periodontitis accompanied by pathological tooth displacement in the anterior region. Methods: This retrospective study analyzed patients diagnosed with severe periodontitis and pathological displacement in the anterior region, who visited both the Periodontics and Orthodontics Departments at Peking University School and Hospital of Stomatology between 2019 and 2022. A total of 26 eligible cases were included in this study. All the patients underwent regular periodontal maintenance throughout the treatment process, and clear aligners were used for orthodontic treatment. Intraoral scans were analyzed by dedicated software to measure and compare occlusal distribution and proximal contact scores before and after orthodontic treatment. Periodontal clinical indicators were assessed at three key time points: before periodontal treatment (T0), before orthodontic treatment (T1), and after orthodontic treatment (T2). All the cases were treated with clear aligner. Results: A total of 217 pathologically displaced anterior teeth from 26 patients were analyzed. Among these, 105 teeth exhibited periodontal pockets [probing depth (PD) ≥5 mm] before periodontal treatment. After clear aligner therapy, the occlusal score improved significantly from 10.35±8.61 to 23.62±9.73 (P < 0.001), and the proximal contact score increased from 13.62±4.73 to 31.62±10.37 (P < 0.001). The median PD decreased significantly from 3.33 mm [interquartile range (IQR)=0.92] at T0 to 2.50 mm (IQR=0.67, P < 0.001) at T1 and remained stable at 2.50 mm (IQR=0.50) after treatment (T2). A significant reduction in PD was observed between T0 and T2 (P < 0.001), but no significant difference was found between T1 and T2 (P=0.948). Conclusion: Clear aligner therapy demonstrates favorable clinical efficacy in patients with severe periodontitis and pathological anterior tooth displacement. It effectively improves occlusal distribution and proximal contact while maintaining periodontal health in these patients. However, further large-scale prospective controlled studies are needed to verify its long-term clinical outcomes.