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Journal of Peking University (Health Sciences) ›› 2022, Vol. 54 ›› Issue (3): 505-510. doi: 10.19723/j.issn.1671-167X.2022.03.016

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Trend analysis of influenza vaccination among hospitalized elderly people in Beijing, 2013-2019

Guang-qi LIU1,Yuan-jie PANG2,Jiang WU3,Min LV3,*(),Meng-ke YU1,Yu-tong LI1,Yang-mu HUANG1,*()   

  1. 1. Department of Global Health, Peking University School of Public Health, Beijing 100191, China
    2. Department of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China
    3. Beijing Center for Disease Prevention and Control, Beijing Research Center for Preventive Medicine, Beijing 100013, China
  • Received:2021-12-22 Online:2022-06-18 Published:2022-06-14
  • Contact: Min LV,Yang-mu HUANG E-mail:8872lm@163.com;ymhuang@bjmu.edu.cn
  • Supported by:
    Capital Health Development Research Fund for Independent Innovation Project(2022-2G-3017);Pilot Project Fund for Public Welfare Development and Reform of Beijing Municipal Medical Research Institutes(2018-1)

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Abstract:

Objective: To analyze the influenza vaccination trend of hospitalized elderly people (≥ 60 years old) in Beijing from 2013 to 2019. Methods: The influenza vaccination status and hospitalization information of elderly people were extracted from the Beijing Elderly Influenza Vaccination database (2013-2019) and the Beijing Urban Employee Basic Medical Insurance database (2013-2019), se-parately. The influenza vaccine coverage rates and annual percentage change were calculated to compare the vaccination trends of elderly people hospitalized due to different diseases. The subjects in 2018-2019 influenza season were divided into different groups according to demographic status, health conditions and hospitalization outcomes to describe and compare the distribution of influenza vaccination rates. Results: The influenza vaccine coverage rates among the elderly people hospitalized due to cardiovascular diseases, cerebrovascular diseases, respiratory diseases or diabetes mellitus were 14.6%, 13.4%, 13.4% and 11.8%, respectively. The influenza vaccination rate among those hospitalized for cardiovascular diseases remained the highest across six influenza seasons and those hospitalized for diabetes mellitus remained the lowest. The largest annual decline of influenza vaccine coverage rate was observed among the hospitalized elderly due to diabetes mellitus (-7.85%). The distribution of vaccinated population was significantly associated with age, gender, hospitalization outcome and comorbidities among the hospitalized elderly people with specific diseases in 2018-2019. Among the elderly people hospitalized due to four different diseases, the vaccination rate of the patients aged 70-79 years was higher than that of the other age groups and that of the patients aged 60-69 years was the lowest. Among the elderly people hospitalized due to respiratory diseases, the vaccination rate of men was higher than that of women, while the situation reversed among the elderly people hospitalized due to cardiovascular diseases and diabetes mellitus. Vaccination rates decreased among the older adults with poor hospitalization outcomes. Among the elderly people hospitalized due to diabetes mellitus, those with 0 comorbidity had the lowest vaccination rate (7.9%). Conclusion: The trend of influenza vaccine coverage rates among the elderly people in Beijing from 2013 to 2019 was downward. We should pay more attention to influenza vaccination in elderly people with diabetes mellitus and aged 60-69 years, and carry out more research on the protective effects of influenza vaccine to promote influenza vaccine coverage among people with chronic diseases.

Key words: Influenza vaccines, Vaccination coverage, Aged, Chronic diseases

CLC Number: 

  • R186

Table 1

Influenza vaccination status among hospitalized elderly people in Beijing from 2013 to 2019 [n (%)]"

Year Diabetes mellitus Cardiovascular diseases Cerebrovascular diseases Respiratory diseases
2013-2014 1 819 (16.0) 5 844 (19.4) 4 668 (16.6) 5 114 (16.6)
2014-2015 2 071 (13.5) 6 061 (15.7) 5 136 (14.2) 5 805 (14.5)
2015-2016 2 002 (11.9) 6 073 (14.1) 5 038 (12.9) 5 620 (12.8)
2016-2017 1 928 (10.1) 5 886 (12.2) 4 738 (11.0) 5 703 (11.7)
2017-2018 2 770 (11.7) 9 273 (14.8) 8 821 (14.4) 8 766 (13.8)
2018-2019 2 687 (10.4) 9 370 (13.6) 8 729 (12.7) 8 441 (12.5)
Total 13 277 (11.8) 42 507 (14.6) 37 130 (13.4) 39 449 (13.4)
APC -7.63 -5.81 -4.11 -4.57

Table 2

Comparison of vaccination and general characteristics among hospitalized elderly people in Beijing from 2018 to 2019"

Items Diabetes mellitus Cardiovascular diseases Cerebrovascular diseases Respiratory diseases
Vaccination coverage rate/% P Vaccination coverage rate/% P Vaccination coverage rate/% P Vaccination coverage rate/% P
Age < 0.001 0.001 0.883 < 0.001
  60-69 years 7.3 9.6 9.3 10.0
  70-79 years 15.6 19.2 17.0 16.6
  ≥80 years 12.9 14.4 12.9 11.6
Gender < 0.001 < 0.001 < 0.001 < 0.001
  Male 9.4 13.2 12.7 13.3
  Female 11.3 14.1 12.7 11.6

Table 3

Comparison of vaccination and hospitalization conditions among hospitalized elderly people in Beijing from 2018 to 2019"

Items Diabetes mellitus Cardiovascular diseases Cerebrovascular diseases Respiratory diseases
Vaccination coverage rate/% P Vaccination coverage rate/% P Vaccination coverage rate/% P Vaccination coverage rate/% P
CCI 0.143 < 0.001 < 0.001 < 0.001
  0 7.9 14.4 11.3 15.1
  1-2 10.1 14.2 13.7 14.0
  3-4 10.6 13.2 12.1 11.1
  ≥5 10.1 10.2 10.2 8.4
Readmission 0.120 < 0.001 < 0.001 < 0.001
  No 10.5 13.8 13.3 13.2
  Yes 9.5 11.3 8.8 8.2
Death 0.034 < 0.001 < 0.001 < 0.001
  No 10.4 13.7 12.8 13.0
  Yes 3.2 8.7 7.5 4.8
Ht < 0.001 < 0.001 < 0.001 < 0.001
  0 10.9 14.4 13.8 14.1
  1 10.6 13.3 12.8 12.7
  ≥2 7.5 10.5 7.8 8.4
1 马洲, 关明, 邢志芳, 等. 流感病毒研究现状与进展[J]. 检验医学, 2020, 35 (12): 1315- 1319.
2 李飒, 刘思家, 朱爱琴, 等. 中国流感死亡负担研究系统综述[J]. 中华预防医学杂志, 2019, 53 (10): 1049- 1055.
3 国家免疫规划技术工作组流感疫苗工作组. 中国流感疫苗预防接种技术指南(2021—2022)[J]. 中华医学杂志, 2021, 101 (40): 3287- 3312.
doi: 10.3760/cma.j.cn112137-20210913-02084
4 朱爱琴, 郑亚明, 秦颖, 等. 中国流感经济负担研究系统综述[J]. 中华预防医学杂志, 2019, 53 (10): 1043- 1048.
5 陈琼, 王丽静, 谢明萱, 等. 老年人流感和肺炎链球菌疫苗接种中国专家建议[J]. 中华老年医学杂志, 2018, 37 (2): 113- 122.
6 彭质斌, 王大燕, 杨娟, 等. 中国流感疫苗应用现状及促进预防接种的政策探讨[J]. 中华流行病学杂志, 2018, 39 (8): 1045- 1050.
doi: 10.3760/cma.j.issn.0254-6450.2018.08.007
7 Mulpuru S , Li L , Ye LY , et al. Effectiveness of influenza vaccination on hospitalizations and risk factors for severe outcomes in hospitalized patients with COPD[J]. Chest, 2019, 155 (1): 69- 78.
doi: 10.1016/j.chest.2018.10.044
8 Cheng Y , Cao X , Cao Z , et al. Effects of influenza vaccination on the risk of cardiovascular and respiratory diseases and all-cause mortality[J]. Ageing Res Rev, 2020, 62, 101124.
doi: 10.1016/j.arr.2020.101124
9 Rodrigues BS , David C , Costa J , et al. Influenza vaccination in patients with heart failure: a systematic review and meta-analysis of observational studies[J]. Heart, 2020, 106 (5): 350- 357.
doi: 10.1136/heartjnl-2019-315193
10 Modin D , Claggett B , Kober L , et al. Influenza vaccination is associated with reduced cardiovascular mortality in adults with diabetes: A nationwide cohort study[J]. Diabetes Care, 2020, 43 (9): 2226- 2233.
doi: 10.2337/dc20-0229
11 World Health Organization. Global influenza programme: Vaccines[EB/OL]. [2021-03-09]. https://www.who.int/teams/global-influenza-programme/vaccines.
12 Centers For Disease Control Prevention. Take time to get a flu vaccine[EB/OL]. (2020-09-25)[2021-03-09]. https://www.cdc.gov/flu/prevent/prevention.htm.
13 World Health Organization . Vaccines against influenza WHO position paper: November 2012[J]. Wkly Epidemiol Rec, 2012, 87 (47): 461- 476.
14 于盂轲, 谢铮, 严述瑞, 等. 北京市提高流感疫苗接种率的经验分析[J]. 中华实用儿科临床杂志, 2019, 34 (2): 116- 119.
15 于孟轲, 吴疆, 吕敏, 等. 2013—2015年流感季北京市老年人流感疫苗接种率趋势分析[J]. 中国疫苗和免疫, 2019, 25 (6): 680- 683.
16 Bannay A , Chaignot C , Blotiere PO , et al. The best use of the Charlson comorbidity index with electronic health care database to predict mortality[J]. Med Care, 2016, 54 (2): 188- 194.
doi: 10.1097/MLR.0000000000000471
17 健康中国行动推进委员会. 健康中国行动(2019—2030年)[R]. 国家卫生健康委员会, 2019.
18 国务院应对新型冠状病毒肺炎疫情联防联控机制综合组. 全国流行性感冒防控工作方案(2020年版)[R]. 国家卫生健康委员会, 2020.
19 杨晓明. 新冠疫情下的流感防控[J]. 中国生物制品学杂志, 2020, 33 (9): 1088.
20 Fifty-sixth World Health Assembly. Resolution WHA56.19. prevention and control of influenza pandemics and annual epidemics[R]. Geneva: World Health Organization, 2003.
21 American Centers For Disease Control Prevention. Flu vaccination coverage, United States, 2019-20 influenza season[EB/OL]. (2020-10-01)[2021-03-14]. https://www.cdc.gov/flu/fluvaxview/coverage-1920estimates.htm.
22 European Centre For Disease Prevention And Control . Seasonal influenza vaccination and antiviral use in EU/EEA Member States: Overview of vaccine recommendations for 2017-2018 and vaccination coverage rates for 2015-2016 and 2016-2017 influenza seasons[M]. Stockholm: ECDC, 2018.
23 王富华, 谢铮, 吕敏, 等. 北京户籍老人免费流感疫苗接种情况及城乡差异分析[J]. 北京大学学报(医学版), 2013, 45 (3): 432- 436.
24 于孟轲, 吴疆, 吕敏, 等. 影响疫苗接种的社会因素综述[J]. 中国疫苗和免疫, 2019, 25 (3): 340- 344.
25 李海月, 吴双胜, 杨鹏, 等. 北京市2008—2010年老年人流行性感冒疫苗接种情况及影响因素分析[J]. 中华流行病学杂志, 2012, 33 (2): 247- 248.
26 Song Y , Zhang T , Chen L , et al. Increasing seasonal influenza vaccination among high risk groups in China: Do community healthcare workers have a role to play?[J]. Vaccine, 2017, 35 (33): 4060- 4063.
27 Wang Q , Yue N , Zheng M , et al. Influenza vaccination coverage of population and the factors influencing influenza vaccination in mainland China: A meta-analysis[J]. Vaccine, 2018, 36 (48): 7262- 7269.
28 Zangiabadian M , Nejadghaderi SA , Mirsaeidi M , et al. Protective effect of influenza vaccination on cardiovascular diseases: A systematic review and meta-analysis[J]. Sci Rep, 2020, 10 (1): 20656.
29 Papaioannou A , Konstantinidi AE , Primikiri E , et al. Influenza vaccination rate among high risk group patients in primary health care in Greece[J]. Cent Eur J Public Health, 2020, 28 (4): 297- 301.
30 Martinez-Huedo MA , Lopez-De-Andres A , Mora-Zaorano E , et al. Decreasing influenza vaccine coverage among adults with high-risk chronic diseases in Spain from 2014 to 2017[J]. Hum Vaccin Immunother, 2020, 16 (1): 95- 99.
31 Lu PJ , Hung MC , O'halloran AC , et al. Seasonal influenza vaccination coverage trends among adult populations, U.S., 2010-2016[J]. Am J Prev Med, 2019, 57 (4): 458- 469.
32 Pang Y , Wang Q , Lv M , et al. Influenza vaccination and hospitalization outcomes among older patients with cardiovascular or respiratory diseases[J]. J Infect Dis, 2021, 223 (7): 1196- 1204.
33 Bechini A , Ninci A , Riccio MD , et al. Impact of influenza vaccination on all-cause mortality and hospitalization for pneumonia in adults and the elderly with diabetes: A meta-analysis of observational studies[J]. Vaccines, 2020, 8 (2): 263.
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