Journal of Peking University(Health Sciences) ›› 2018, Vol. 50 ›› Issue (6): 952-955. doi: 10.19723/j.issn.1671-167X.2018.06.002

• Article • Previous Articles     Next Articles

  

  • Received:2018-10-18 Online:2018-12-18 Published:2018-12-17

RICH HTML

  

CLC Number: 

  • R593.2

Table 1

Association between ANAs and tumor types"

CTD ANAs Tumor
SLE Anti-Sm antibody Lung cancer, pancreatic cancer, colon cancer, cervical cancer
Anti-SS-A antibody Lymphoma, myeloma,teratoma
Anti-SS-B antibody NHL, squamous cell carcinoma
SSc Scl-70 Lung cancer, ovarian cancer, breast cancer
pSS Anti-SS-A antibody NHL, squamous cell carcinoma
Anti-SS-B antibody NHL
[1] Burnham TK . Antinuclear antibodies in patients with malignancies[J]. Lancet, 1972,2(7774):436.
doi: 10.1016/S0140-6736(72)91842-9 pmid: 4115262
[2] Vlagea A, Falagan S, Gutierrez-Gutierrez G , et al. Antinuclear antibodies and cancer: A literature review[J]. Crit Rev Oncol Hematol, 2018,127:42-49.
doi: 10.1016/j.critrevonc.2018.05.002
[3] Sahin U, Tureci O, Schmitt H , et al. Human neoplasms elicit multiple specific immune responses in the autologous host[J]. Proc Natl Acad Sci USA, 1995,92(25):11810-11813.
doi: 10.1073/pnas.92.25.11810 pmid: 8524854
[4] Dellen H, Seemayer NH . Autoimmunity in patients with bronchogenic carcinomas: occurrence of antibodies against nuclear antigens, chromosomes and ds-deoxyribonucleic acid[J]. Zentralbl Bakteriol Mikrobiol Hyg B, 1983,177(6):451-468.
pmid: 6322478
[5] Riska H, Fyhrquist F, Selander RK , et al. Systemic lupus erythematosus and DNA antibodies in pleural effusions[J]. Scand J Rheumatol, 1978,7(3):159-160.
doi: 10.3109/03009747809095646 pmid: 310156
[6] Attar SM, Koshak EA . Medical conditions associated with a positive anti-double-stranded deoxyribonucleic acid[J]. Saudi Med J, 2010,31(7):781-787.
doi: 10.5336/medsci.2009-16065 pmid: 20635012
[7] Cavagna L, Prisco E, Montecucco C , et al. Association between anti-dsDNA titre increase and thymoma relapse[J]. Clin Exp Rheumatol, 2011,29(3):599-600.
[8] 邹和建 . 系统性红斑狼疮与自身抗体[J]. 皮肤科学通报, 2018,35(3):258-264.
[9] Katz U, Zandman-Goddard G . Drug-induced lupus: an update[J]. Autoimmun Rev, 2010,10(1):46-50.
doi: 10.1016/j.autrev.2010.07.005 pmid: 20656071
[10] Kamei M, Kato M, Mochizuki K , et al. Serodiagnosis of cancers by ELISA of anti-histone H2B antibody[J]. Biotherapy, 1992,4(1):17-22.
doi: 10.1007/BF02171705 pmid: 1543647
[11] Sakamoto J, Fujiya M, Okamoto K , et al. Immunoprecipitation of nucleosomal DNA is a novel procedure to improve the sensitivity of serum screening for the p16 hypermethylation associated with colon cancer[J]. Cancer Epidemiol, 2010,34(2):194-199.
doi: 10.1016/j.canep.2010.01.004 pmid: 20129840
[12] Fragkioudaki S, Mavragani CP, Moutsopoulos HM . Predicting the risk for lymphoma development in Sjögren syndrome: An easy tool for clinical use[J]. Medicine, 2016,95(25):e3766.
doi: 10.1097/MD.0000000000003766
[13] Quartuccio L, Baldini C, Bartoloni E , et al. Anti-SSA/SSB-negative Sjögren’s syndrome shows a lower prevalence of lymphoproliferative manifestations, and a lower risk of lymphoma evolution[J]. Autoimmun Rev, 2015,14(11):1019-1022.
doi: 10.1016/j.autrev.2015.07.002
[14] Matsuda M , Yamada T. snRNPs from mouse teratocarcinoma cells reacting with polyclonal anti-Sm and anti-m3(2,2,7)G antibodies and bioche-mical characterization of the snRNPs[J]. Nihon Juigaku Zasshi, 1987,49(6):981-987.
doi: 10.1292/jvms1939.49.981 pmid: 2963163
[15] Imran A, Neelam F, Tariq M . Incidence of circulating antinuclear antibodies in cancer patients[J]. Indian J Med Sci, 2003,57(3):113-116.
pmid: 14514262
[16] Zou HY, Gu X, Yu WZ , et al. Detection of serum antinuclear antibodies in lymphoma patients[J]. Genet Mol Res, 2015,14(4):16546-16552.
doi: 10.4238/2015.December.11.1 pmid: 26681000
[17] Fernandez-Madrid F , VandeVord PJ, Yang X, et al. Antinuclear antibodies as potential markers of lung cancer[J]. Clin Cancer Res, 1999,5(6):1393-1400.
doi: 10.1590/S0004-282X1994000300022 pmid: 10389924
[18] Syrigos KN, Charalambopoulos A, Pliarchopoulou K , et al. The prognostic significance of autoantibodies against dsDNA in patients with colorectal adenocarcinoma[J]. Anticancer Res, 2000,20(6B):4351-4353.
doi: 10.1097/00001813-200011000-00012 pmid: 11205270
[19] Mitchell P, Thatcher N, Socinski MA , et al. Tecemotide in unresectable stage III non-small-cell lung cancer in the phase III START study: updated overall survival and biomarker analyses[J]. Ann Oncol, 2015,26(6):1134-1142.
doi: 10.1093/annonc/mdv104 pmid: 25722382
[20] Maire C, Vercambre-Darras S, Devos P , et al. Metastatic melanoma: spontaneous occurrence of auto antibodies is a good prognosis factor in a prospective cohort[J]. J Eur Acad Dermatol Venereol, 2013,27(1):92-96.
doi: 10.1111/j.1468-3083.2011.04364.x pmid: 22145691
[21] Altintas A, Cil T, Pasa S , et al. Clinical significance of elevated antinuclear antibody test in patients with Hodgkin’s and non-Hodgkin’s lymphoma: a single center experience[J]. Minerva Med, 2008,99(1):7-14.
[22] Tan EM . Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology[J]. Adv Immunol, 1989,44:93-151.
doi: 10.1016/S0065-2776(08)60641-0
[23] Ringrose JH, Muijsers AO, Pannekoek Y , et al. Influence of infection of cells with bacteria associated with reactive arthritis on the peptide repertoire presented by HLA-B27[J]. J Med Microbiol, 2001,50(4):385-389.
doi: 10.1086/319288 pmid: 11289525
[24] Clark SE, Weiser JN . Microbial modulation of host immunity with the small molecule phosphorylcholine[J]. Infect Immun, 2013,81(2):392-401.
doi: 10.1128/IAI.01168-12 pmid: 3553803
[25] Flodstrom-Tullberg M . Viral infections: their elusive role in regulating susceptibility to autoimmune disease[J]. Microbes Infect, 2003,5(10):911-921.
doi: 10.1016/S1286-4579(03)00161-8 pmid: 12919859
[26] Monsalve DM, Pacheco Y, Acosta-Ampudia Y , et al. Zika virus and autoimmunity. One-step forward[J]. Autoimmun Rev, 2017,16(12):1237-1245.
doi: 10.1016/j.autrev.2017.10.008 pmid: 29037898
[27] Sene D, Piette JC, Cacoub P . Antiphospholipid antibodies, antiphospholipid syndrome and infections[J]. Autoimmun Rev, 2008,7(4):272-277.
doi: 10.1016/j.autrev.2007.10.001 pmid: 18295729
[28] Tanay A . Chikungunya virus and autoimmunity[J]. Curr Opin Rheumatol, 2017,29(4):389-393.
doi: 10.1097/BOR.0000000000000396
[29] Wan SW, Lin CF, Yeh TM , et al. Autoimmunity in dengue pathogenesis[J]. J Formos Med Assoc, 2013,112(1):3-11.
doi: 10.1016/j.jfma.2012.11.006
[30] Garzelli C, Pacciardi A, Basolo F , et al. Mechanisms other than polyclonal B cell activation possibly involved in Epstein-Barr virus-induced autoimmunity[J]. Clin Exp Immunol, 1989,76(3):412-416.
doi: 10.1002/chir.22478 pmid: 2546702
[31] Kivity S, Agmon-Levin N, Blank M , et al. Infections and autoimmunity: friends or foes?[J]. Trends Immunol, 2009,30(8):409-414.
doi: 10.1016/j.it.2009.05.005 pmid: 19643667
[32] Rubtsova K , Rubtsov AV, van Dyk LF, et al. T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance[J]. Proc Natl Acad Sci USA, 2013,110(34):E3216-3224.
doi: 10.1073/pnas.1312348110 pmid: 23922396
[33] Yee LJ, Kelleher P, Goldin RD , et al. Antinuclear antibodies (ANA) in chronic hepatitis C virus infection: correlates of positivity and clinical relevance[J]. J Viral Hepat, 2004,11(5):459-464.
doi: 10.1111/j.1365-2893.2004.00530.x pmid: 15357653
[34] Hao Y , O’Neill P, Naradikian MS, et al. A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice[J]. Blood, 2011,118(5):1294-1304.
doi: 10.1182/blood-2011-01-330530
[35] Litwin CM, Binder SR . ANA testing in the presence of acute and chronic infections[J]. J Immunoassay Immunochem, 2016,37(5):439-452.
doi: 10.1080/15321819.2016.1174136 pmid: 27050929
[36] Shoenfeld Y, Vilner Y, Coates AR , et al. Monoclonal anti-tuberculosis antibodies react with DNA, and monoclonal anti-DNA autoantibodies react with Mycobacterium tuberculosis[J]. Clin Exp Immunol, 1986,66(2):255-261.
doi: 10.1016/0008-8749(86)90083-3 pmid: 3102132
[37] Faaber P, Capel PJ, Rijke GP , et al. Cross-reactivity of anti-DNA antibodies with proteoglycans[J]. Clin Exp Immunol, 1984,55(3):502-508.
pmid: 6608423
[1] Hui WEI, Jingfeng ZHANG, Zhongqiang YAO, Jinxia ZHAO. Clinical characteristics and relevant factors of rheumatoid arthritis patients with anemia of chronic disease [J]. Journal of Peking University (Health Sciences), 2026, 58(2): 307-312.
[2] Jiyan CHU, Ping LI, Jing TIAN, Diyu FU, Lin GUO, Rui SUN, Yadi LI. Expression of the melanoma 2-mediated pyroptosis pathway in peripheral blood mononuclear cells of patients with idiopathic inflammatory myopathies [J]. Journal of Peking University (Health Sciences), 2026, 58(1): 175-183.
[3] Yuan LIU, Guixiu SHI. Change from Sjögren syndrome to Sjögren disease [J]. Journal of Peking University (Health Sciences), 2025, 57(6): 1015-1017.
[4] Yirui LIAN, Jingxuan LIU, Liang ZHAO, Jing ZHAO, Sitian ZANG, Yuhui LI. Rheumatic disease spectrum and immunological profile of anti-PM/Scl antibodies in idiopathic inflammatory myopathies [J]. Journal of Peking University (Health Sciences), 2025, 57(6): 1018-1023.
[5] Tao WU, Jianzi LIN, Yafeng ZHU, Jianda MA, Peiwen JIA, Lijuan YANG, jie PAN, Yaowei ZOU, Ying YANG, Ye LU, Lie DAI. Serum inter-alpha-trypsin inhibitor heavy chain H3 is identified as a potential biomarker for myopenia in patients with rheumatoid arthritis using proteomic profiling [J]. Journal of Peking University (Health Sciences), 2025, 57(6): 1024-1031.
[6] Wenhao LIN, Yang XIE, Fangqing WANG, Shuying WANG, Xiangjun LIU, Fanlei HU, Yuan JIA. Single-cell RNA sequencing of B cells reveals molecular typing in Sjögren syndrome [J]. Journal of Peking University (Health Sciences), 2025, 57(6): 1032-1041.
[7] Zhao XIANG, Li YANG, Jing YANG. Untargeted metabolomics reveals differential serum metabolites and metabolic pathways in patients with primary Sjögren syndrome and thrombocytopenia [J]. Journal of Peking University (Health Sciences), 2025, 57(6): 1042-1050.
[8] Yayun ZHAO, Mengfan NI, Xue LI, Bei WANG, Gong CHENG, Jing HE, Yuebo JIN. Clinical efficacy and safety of rituximab in treating renal injury in primary Sjögren syndrome [J]. Journal of Peking University (Health Sciences), 2025, 57(6): 1051-1060.
[9] Jiajing PENG, Li CUI. Clinical features and prognosis of sarcoidosis with ocular lesions as the initial manifestation [J]. Journal of Peking University (Health Sciences), 2025, 57(6): 1061-1066.
[10] Yajing GAO, Zhengfang LI, Mengsi MA, Lijun WU. Role of the SII and SIRI in risk prediction, disease activity assessment, and prog-nostic evaluation of Behçet disease uveitis [J]. Journal of Peking University (Health Sciences), 2025, 57(6): 1067-1073.
[11] Xiaolin WANG, Shaoyi GUO, Dazhao CHEN, Xijie WEN, Yong HUA, Liang ZHANG, Qin ZHANG. A follow-up study on total hip arthroplasty in patients with systemic lupus erythematosus combined with osteonecrosis of femoral head [J]. Journal of Peking University (Health Sciences), 2025, 57(6): 1081-1088.
[12] Xinfeng WU, Siliang MAN, Dazhao CHEN, Yong HUA, Xijie WEN, Yingyue DING, Liang ZHANG, Xiujuan HOU. A long-term review for radiographic parameters of hips in axial spondyloarthritis patients with end-stage hip involvement: A 24-year trend analysis from a single high-volume tertiary center [J]. Journal of Peking University (Health Sciences), 2025, 57(6): 1089-1095.
[13] Jingwen LAN, Zhe CHEN, Yongjing CHENG, Like ZHAO. Clinical characteristics, efficacy and safety of antifibrotic agents in elderly patients with connective tissue disease-associated interstitial lung disease [J]. Journal of Peking University (Health Sciences), 2025, 57(6): 1101-1106.
[14] Yanyan LI, Xiangjun LIU, Gongming LI, Chun LI, Yuan JIA. Clinic behavior and therapeutic status of patients with antiphospholipid syndrome [J]. Journal of Peking University (Health Sciences), 2025, 57(6): 1107-1112.
[15] Chun WEI, Yue YANG, Xinju ZHAO, Xu LIU, Yuan JIA. Systemic lupus erythematosus complicated by autoimmune nodopathy: A case report [J]. Journal of Peking University (Health Sciences), 2025, 57(6): 1174-1179.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!