北京大学学报(医学版) ›› 2022, Vol. 54 ›› Issue (5): 814-821. doi: 10.19723/j.issn.1671-167X.2022.05.006

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类器官在癌症研究、药物筛选与精准诊疗中的应用进展

张宁*(),杨慧,王鹏   

  • 收稿日期:2022-08-04 出版日期:2022-10-18 发布日期:2022-10-14
  • 通讯作者: 张宁 E-mail:zhangning@bjmu.edu.cn
  • 作者简介:张宁,教授,国家“万人计划”入选者,国家杰出青年科学基金获得者,科技部中青年科技创新领军人才,人事部百千万人才,天津市杰出人才,教育部新世纪优秀人才,天津市特聘教授,天津市“千人计划”入选者,天津市十佳杰出留学回国人员,天津青年科技奖获得者,美国李氏基金会杰出成就奖获得者。现担任北京大学第一医院肿瘤转化与研究中心常务副主任,天津医科大学肿瘤医院研究所学术带头人,中国抗癌协会常务理事、副秘书长,中国抗癌协会期刊出版专业委员会主任委员,纳米肿瘤学专业委员会前任主任委员,Cancer Biology & Medicine常务副主编。近五年在Cancer CellGastroenterologyNature CommunicationsGenome Research等国际期刊中发表SCI文章48篇,总影响因子为436.827,在癌症研究领域产生了重要影响。
    长期从事生物医学、细胞生物学及肝癌异质性研究,围绕癌转移这一关键临床难题,从机制研究、生物标志物鉴定、药物筛选、分子遗传学、纳米技术等多个侧面入手展开转化应用研究,取得了一系列科研成果。在肝癌异质性研究领域,开展大规模、具有病种代表性的肝癌患者的单细胞组学研究,揭示肝癌细胞异质性规律和肝癌免疫微环境抑制性规律,结合临床信息,揭示新的治疗靶点和免疫微环境种类

宁 张*(),慧 杨,鹏 王   

  • Received:2022-08-04 Online:2022-10-18 Published:2022-10-14
  • Contact: 宁 张 E-mail:zhangning@bjmu.edu.cn

RICH HTML

  

关键词: 肿瘤类器官, 药物筛选, 精准诊疗

中图分类号: 

  • R735.3

图1

肿瘤免疫共培养的类器官系统 在holistic方法中,肿瘤细胞悬液培养在气液平面中,该悬液中包含所有类型的肿瘤细胞、内源性免疫细胞和成纤维细胞等,以产生肿瘤免疫类器官。在reductionist方法中,肿瘤细胞悬液主要为肿瘤细胞,之后与来自同一患者外周血的自体免疫细胞共培养,以促进肿瘤反应性T细胞的连续扩增。NK细胞, 自然杀伤细胞。"

图2

类器官在癌症研究、药物筛选和精准医学领域的应用 从患者的正常组织培养类器官进行基因编辑可形成肿瘤类器官,也可取样自患者的肿瘤组织建立类器官,进而建立肿瘤类器官生物库。肿瘤类器官生物库为研究肿瘤进展、药物筛选及精准诊疗提供了良好的平台。"

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