北京大学学报（医学版） ›› 2023, Vol. 55 ›› Issue (6): 953-957. doi: 10.19723/j.issn.1671-167X.2023.06.001
• 专家笔谈 • 下一篇
嵌合抗原受体T细胞治疗在自身免疫疾病中的应用和思考
扶琼,叶霜*(
)
- 上海交通大学医学院附属仁济医院风湿科, 上海 200001
琼 扶,霜 叶*()
中图分类号:
- R593.2
| 1 |
Wang L , Wang FS , Gershwin ME . Human autoimmune diseases: A comprehensive update[J]. J Intern Med, 2015, 278 (4): 369- 395.
doi: 10.1111/joim.12395 |
| 2 |
Arbuckle MR , McClain MT , Rubertone MV , et al. Development of autoantibodies before the clinical onset of systemic lupus erythematosus[J]. N Engl J Med, 2003, 349 (16): 1526- 1533.
doi: 10.1056/NEJMoa021933 |
| 3 |
Furie RA , Aroca G , Cascino MD , et al. B-cell depletion with obinutuzumab for the treatment of proliferative lupus nephritis: A randomised, double-blind, placebo-controlled trial[J]. Ann Rheum Dis, 2022, 81 (1): 100- 107.
doi: 10.1136/annrheumdis-2021-220920 |
| 4 |
Baker DJ , Arany Z , Baur JA , et al. CAR T therapy beyond cancer: The evolution of a living drug[J]. Nature, 2023, 619 (7971): 707- 715.
doi: 10.1038/s41586-023-06243-w |
| 5 |
Maldini CR , Ellis GI , Riley JL . CAR T cells for infection, autoimmunity and allotransplantation[J]. Nat Rev Immunol, 2018, 18 (10): 605- 616.
doi: 10.1038/s41577-018-0042-2 |
| 6 | Schett G, Mackensen A, Mougiakakos D. CAR T-cell therapy in autoimmune diseases[J/OL]. Lancet, (2023-09-22)[2023-10-12]. https://doi.org/10.1016/S0140-6736(23)01126-1. |
| 7 |
Mougiakakos D , Krönke G , Völkl S , et al. CD19-targeted CAR T cells in refractory systemic lupus erythematosus[J]. N Engl J Med, 2021, 385 (6): 567- 569.
doi: 10.1056/NEJMc2107725 |
| 8 |
Mackensen A , Müller F , Mougiakakos D , et al. Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus[J]. Nat Med, 2022, 28 (10): 2124- 2132.
doi: 10.1038/s41591-022-02017-5 |
| 9 |
Zhang W , Feng J , Cinquina A , et al. Treatment of systemic lupus erythematosus using BCMA-CD19 compound CAR[J]. Stem Cell Rev Rep, 2021, 17 (6): 2120- 2123.
doi: 10.1007/s12015-021-10251-6 |
| 10 |
Qin C , Tian DS , Zhou LQ , et al. Anti-BCMA CAR T-cell therapy CT103A in relapsed or refractory AQP4-IgG seropositive neuromyelitis optica spectrum disorders: Phase 1 trial interim results[J]. Signal Transduct Target Ther, 2023, 8 (1): 5.
doi: 10.1038/s41392-022-01278-3 |
| 11 |
Müller F , Boeltz S , Knitza J , et al. CD19-targeted CAR T cells in refractory antisynthetase syndrome[J]. Lancet, 2023, 401 (10379): 815- 818.
doi: 10.1016/S0140-6736(23)00023-5 |
| 12 |
Pecher AC , Hensen L , Klein R , et al. CD19-targeting CAR T cells for myositis and interstitial lung disease associated with antisynthetase syndrome[J]. JAMA, 2023, 329 (24): 2154- 2162.
doi: 10.1001/jama.2023.8753 |
| 13 |
Bergmann C , Müller F , Distler JHW , et al. Treatment of a patient with severe systemic sclerosis (SSc) using CD19-targeted CAR T cells[J]. Ann Rheum Dis, 2023, 82 (8): 1117- 1120.
doi: 10.1136/ard-2023-223952 |
| 14 |
Granit V , Benatar M , Kurtoglu M , et al. Safety and clinical activity of autologous RNA chimeric antigen receptor T-cell therapy in myasthenia gravis (MG-001): A prospective, multicentre, open-label, non-randomised phase 1b/2a study[J]. Lancet Neurol, 2023, 22 (7): 578- 590.
doi: 10.1016/S1474-4422(23)00194-1 |
| 15 |
Ellebrecht CT , Bhoj VG , Nace A , et al. Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease[J]. Science, 2016, 353 (6295): 179- 184.
doi: 10.1126/science.aaf6756 |
| 16 |
Sun Y , Yuan Y , Zhang B , et al. CARs: A new approach for the treatment of autoimmune diseases[J]. Sci China Life Sci, 2023, 66 (4): 711- 728.
doi: 10.1007/s11427-022-2212-5 |
| 17 |
Riet T , Chmielewski M . Regulatory CAR-T cells in autoimmune diseases: Progress and current challenges[J]. Front Immunol, 2022, 13, 934343.
doi: 10.3389/fimmu.2022.934343 |
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