北京大学学报(医学版) ›› 2015, Vol. 47 ›› Issue (2): 349-351. doi: 10.3969/j.issn.1671-167X.2015.02.032

• 病例报告 • 上一篇    下一篇

白细胞趋化因子2型肾淀粉样变性病1例

王妍,王素霞△,章友康   

  1. (北京大学第一医院肾内科,北京大学肾脏疾病研究所,卫生部肾脏疾病重点实验室,慢性肾脏病防治教育部重点实验室,北京 100034)
  • 出版日期:2015-04-18 发布日期:2015-04-18

Leukocyte chemotactic factor 2 associated renal amyloidosis: one case report

WANG Yan, WANG Su-xia△, ZHANG You-kang   

  1. (Renal Division, Department of Medicine, Peking University First Hospital; Institute of Nephrology, Peking University; Key laboratory of Renal Disease, Ministry of Health of China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education of China, Beijing 100034, China)
  • Online:2015-04-18 Published:2015-04-18

关键词:  肾, 淀粉样变性, 趋化因子类

Abstract: Here we report a case of leukocyte chemotactic factor 2 (LECT2)-associated renal amyloidosis (ALect2) in our hospital. A 68yearold male presented with massive proteinuria, hematuria, and hypertension. The renal function was normal. Light microscopy of the renal biopsy revealed glomeruli,interstitium and arteriole with amorphous pink acellular deposits on hematoxylin and eosin stain. The deposits were strongly stained for Congo red and presented apple green birefringence viewed with polarized light. Ultrastructural examination revealed nonbranching fibrils (diameters ranging from 8 nm to 12 nm) distributed in glomerular mesangium, subendothelia and renal interstitium. Immunohistochemistry and immunoelectron microscopy using a polyclonal antiLECT2 antibody showed that the amyloid deposits and the fibrils were stained positively. ALect2 presented proteinuria,with or without acute/chronic renal dysfunction clinically and all compartments of the kidney were involved.

Key words: Kidney, Amyloidosis, Chemotactic factors

中图分类号: 

  • R597.2

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