Email Alert | RSS

北京大学学报（医学版） ›› 2019, Vol. 51 ›› Issue (2): 288-292. doi: 10.19723/j.issn.1671-167X.2019.02.017

• 论著 • 上一篇    下一篇

滥用一氧化二氮致长节段脊髓病变的临床分析

王云云1,汪仁斌2,洪闻3,焦劲松2,彭丹涛2,刘尊敬2,田朝晖2,金淼2,董明睿2,段晓慧2,刘蕾2,孙青2,孙少杰2,王丽2,∆()   

  1. 1. 中日友好医院 保健部二部, 北京 100029
    2. 中日友好医院 神经内科, 北京 100029
    3. 中日友好医院 放射诊断科, 北京 100029
  • 收稿日期:2018-10-11 出版日期:2019-04-18 发布日期:2019-04-26
  • 通讯作者: 王丽 E-mail:WL0050685@sina.com.cn
  • 基金资助:
    国家自然科学基金(81300942);中日友好医院青年科技英才计划项目(2015-QNYC-A-05)

Clinical features of long segmental myelopathy caused by nitrous oxide

Yun-yun WANG1,Ren-bin WANG2,Wen HONG3,Jin-song JIAO2,Dan-tao PENG2,Zun-jing LIU2,Zhao-hui TIAN2,Miao JIN2,Ming-rui DONG2,Xiao-hui DUAN2,Lei LIU2,Qing SUN2,Shao-jie SUN2,Li WANG2,∆()   

  1. 1. The Second Health and Medical Department, China-Japan Friendship Hospital, Beijing 100029, China
    2. Department of Neurology, China-Japan Friendship Hospital, Beijing 100029, China
    3. Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China
  • Received:2018-10-11 Online:2019-04-18 Published:2019-04-26
  • Contact: Li WANG E-mail:WL0050685@sina.com.cn
  • Supported by:
    the National Natural Science Foundation of China(81300942);Youth Science and Technology Talents Project of China-Japan Friendship Hospital(2015-QNYC-A-05)

RICH HTML

   

PDF (PC)

摘要：

目的: 分析滥用一氧化二氮导致长节段脊髓病变的临床表现和影像学特点。方法: 对2015年10月至2018年2月在中日友好医院神经科就诊的10例滥用一氧化二氮患者的人口学数据、一氧化二氮接触史、临床特点、实验室检查、神经电生理检查、脊髓磁共振成像及治疗效果等进行回顾性分析。结果: 10例患者中男性4例,女性6例,年龄17~26岁[平均年龄(20.80±3.12)岁]。10例患者吸入N2O至起病时间为1个月至1年,平均时间(6.95±4.19)个月。10例均以肢体远端无力为主要症状,9例伴肢体远端麻木,3例伴Lhermitte’s征(+),4例伴尿便障碍。2例血常规提示贫血,1例为巨细胞性贫血,1例为小细胞低色素性贫血。3例曾于外院补充维生素B12治疗,其余7例血清同型半胱氨酸均异常增高。电生理检查示9例患者感觉和运动神经均受累,1例仅运动神经受累,下肢病变严重程度明显重于上肢。脊髓磁共振成像示10例均有颈髓纵行条状T2高信号,3例伴胸髓长节段病变,2例伴脊髓肿胀,6例横轴位呈“倒V”征,1例呈“类月牙”征,3例呈“八字”征。10例均在停止一氧化二氮吸入、积极补充大剂量维生素B12、早期康复锻炼治疗后,症状有不同程度缓解。结论: 一氧化二氮中毒性脊髓病变临床多以肢体远端无力麻木为主,影像学上以颈段脊髓后索受累常见,可伴有胸髓受累,横轴位以“倒V”征多见。停止接触一氧化二氮和补充高剂量维生素B12有效。

关键词: 一氧化二氮, 维生素B12, 长节段脊髓病变

Abstract:

Objective: To analyze the clinical and imaging characteristics of the neurological damage caused by nitrous oxide (N2O).Methods: In the study, 10 patients in the Department of Neurology of China-Japan Friendship Hospital from October 2015 to February 2018 were retrospectively analyzed for the demographic data, the history of inhaled N2O, clinical features, blood examination, electrophysiolo-gical examination, spinal magnetic resonance imaging and therapeutic efficacy profiles.Results: The male-to-female ratio was 4 ∶6 and it presented with an age-of-onset 17-26 years [the average age: (20.80±3.12) years]. The time from inhaled N2O to onset was 1 month to 1 year [the average time: (6.95±4.19) months]. Paralysis in all the patients and numbness in 9 patients were the main clinical features, while positive Lhermitte’s sign in 3 patients, urinary and defecation disturbance in 4 patients were also found. Blood examination indicated anemia in 2 patients, giant cell anemia in 1 case and small cell hypochromic anemia in 1 case. 3 cases had been treated with vitamin B12 in an external hospital, and the other 7 cases had abnormal increase in homocysteine levels. Electrophysiological examinations showed sensory and motor nerve involvement in 9 patients, and motor nerve involvement in 1 patient. The severity of lower extremity lesion was significantly heavier than that of upper extremity. Spinal magnetic resonance imagings showed that long segmental lesions were present in the cervical spinal cord of all the patients, 3 cases with long segmental lesions of the thoracic cord and 2 cases with spinal cord swelling. In 6 cases, the horizontal axis had an “inverted V-type” T2 high signal, 1 case was classified as “cre-scent”, and 3 cases were “eight-shaped”. The symptoms in these 10 cases were alleviated in varying degrees after stopping the inhalation of nitrous oxide, actively supplementing high doses of vitamin B12 and doing early rehabilitation exercises.Conclusion: Myelopathy with nitrous oxide presents as paralysis and numbness in limb extremities. In imaging, cervical spinal cord damage is common, accompanied by thoracic spinal cord damage. The horizontal axis is more common in the “inverted V-type”. Treatment with high doses of vitamin B12 is effective.

Key words: Nitrous oxide, Vitamin B12, Long segmental myelopathy

中图分类号: 

  • R744.6

表1

10例患者的临床特点"

Case Mental symptoms Numbness Limb weakness Urinary dysfunction
1 Normal Both hands, hypoesthesia below T4 Double lower limbs→arms Exist
2 Irritability Both hands, legs below the knee Extremities Exist
3 Normal Extremities distal to proximal, Lhermitte’s sign(+) Extremities Normal
4 Normal Normal Double lower limbs Normal
5 Irritability Extremities distal Double feet→extremities Normal
6 Normal Extremities distal Double feet→extremities Normal
7 Hallucination Double lower limbs→hands, Lhermitte’s sign(+) Double feet→extremities Exist
8 Normal Double lower limbs→hands Double lower limbs Exist
9 Normal Extremities Extremities Normal
10 Hallucination Extremities distal, Lhermitte’s sign(+) Extremities Exist

图1

病例1矢状位显示颈髓背侧纵行条状T2高信号,轴位T2WI呈“倒V”征"

图2

病例2治疗前矢状位显示颈髓增粗、肿胀,颈髓内T2高信号,轴位呈“类月牙”征"

图3

病例3轴位T2WI病变未融合,呈“八字”征"

图4

病例2治疗2个月后复查,矢状位显示颈髓肿胀消失,轴位呈“倒V”征"

[1] 王丽, 范其江, 焦劲松 , 等. 滥用笑气中毒致神经系统损害一例[J]. 中国现代神经疾病杂志, 2016,16(8):533-537.
[2] 姜季委, 石碧川, 商秀丽 . 笑气中毒致脊髓亚急性联合变性2例报告[J]. 中风与神经疾病杂志, 2018,35(4):352-354.
[3] 于文慧, 李德雨, 何志义 . “笑气”中毒导致神经系统损害4例并文献复习[J]. 卒中与神经疾病杂志, 2018,25(5):556-561.
[4] Gillman MA . Nitrous oxide has a very low abuse potential[J]. Addiction, 1995,90(3):439.
doi: 10.1111/add.1995.90.issue-3
[5] Wu LT, Pilowsky DJ, Schlenger WE . Inhalant abuse and depen-dence among adolescents in the United States[J]. J Am Acad Child Adolesc Psychiatry, 2004,43(10):1206-1214.
doi: 10.1097/01.chi.0000134491.42807.a3
[6] Garland EL, Howard MO, Perron BE . Nitrous oxide inhalation among adolescents: prevalence, correlates, and co-occurrence with volatile solvent inhalation[J]. J Psychoactive Drugs, 2009,41(4):337-347.
doi: 10.1080/02791072.2009.10399771
[7] Garakani A, Jaffe RJ, Savla D , et al. Neurologic, psychiatric,and other medical manifestations of nitrous oxide abuse: a syste-matic review of the case literature[J]. Am J Addict, 2016,25(5):358-369.
doi: 10.1111/ajad.v25.5
[8] Dimaio VJ, Garriot JC . Four deaths resulting from abuse of nitrous oxide[J]. J Forensic Sci, 1978,23(1):169-172.
[9] Potocka-Banas B, Majdanik S, Dutkiewicz G , et al. Death caused by addicitive inhalation of nitrous oxide[J]. Hum Exp Toxicol, 2011,30(11):1875-1877.
doi: 10.1177/0960327111401437
[10] Duque MA, Kresak JL, Falchook A , et al. Nitrous oxide abuse and vitamin B12 action in a 20-year-old women: a case report[J]. Lab Med, 2015,46(4):312-315.
doi: 10.1309/LM0L9HAVXCHF1UQM
[11] Morris N, Lynch K, Greenbery SA . Severe motor neuropathy or neuronopathy due to nirous oxide toxicity after correction of vitamin B12 deficiency[J]. Muscle Nerve, 2015,51(4):614-616.
doi: 10.1002/mus.24482
[12] 蒋雯巍, 蒋雨平 . 甲钴胺代谢及其相关性疾病[J]. 中国临床神经病学杂志, 2010,18(2):203-207.
[13] Kumar A, Singh AK . Teaching neuroimage: inverted V sign in subacute combined degeneration of spinal cord[J]. Neurology, 2009,72(1):e4.
doi: 10.1212/01.wnl.0000338663.59433.9c
[14] 王文超, 丁汉军, 刘明 , 等. MRI对脊髓亚急性联合变性的诊断价值[J]. 中华放射学杂志, 2000,34(1):40-42.
[15] 腾才钧, 陈玲, 覃盛宝 , 等. 脊髓亚急性联合变性MRI影像分析[J]. 实用放射学杂志, 2016,32(7):1009-1011.
[16] Locatelli ER, Laureno R, Ballard P , et al. MRI in vitamin B12 deficiency myelopathy[J]. Can J Neurol Sci, 1999,26(1):60-63.
[17] Li HT, Chu CC, Chang KH , et al. Clinical and electrodiagnostic characteristics of nitrous oxide-induced neuropathy in Taiwan[J]. Clin Neurophysiol, 2016,127(10):3288-3293.
doi: 10.1016/j.clinph.2016.08.005
[18] Hutto BR . Folate and cobalamin in psycheiatric illness[J]. Compr Psychiatry, 1997,38(6):305-314.
doi: 10.1016/S0010-440X(97)90925-1
[19] Brodsky L, Zuniga J . Nitrous oxide: a psychotogenic agent[J]. Compr Psychiatry, 1975,16(2):185-188.
doi: 10.1016/0010-440X(75)90065-6
[20] Gursoy AE, Kolukisa M, Babacan-Yildiz G , et al. Subacute combined degeneration of the spinal cord due to different etiologies and improvement of MRI findings[J]. Case Rep Neurol Med, 2013,2013(1):159649.
[1] 孟磊, 高炜, 赵春玉, 薛林. 高同型半胱氨酸血症引起家兔动脉硬化[J]. 北京大学学报（医学版）, 2001, 33(6): 536-539.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
ISSN 1671-167X
CN 11-4691/R
主管单位：中华人民共和国教育部
主办单位：北京大学
地址： 北京市海淀区学院路38号 北京大学医学部 《北京大学学报（医学版）》
邮编：100191
电话：010-82801551
Email： xbbjb2@bjmu.edu.cn

《北京大学学报（医学版）》
微信公众号
版权所有 © 2018 《北京大学学报（医学版）》编辑部