156例特应性皮炎患者血清吸入和食物过敏原特异性免疫球蛋白E及患者自觉过敏情况

doi:10.19723/j.issn.1671-167X.2020.05.032

北京大学学报（医学版） ›› 2020, Vol. 52 ›› Issue (5): 980-984. doi: 10.19723/j.issn.1671-167X.2020.05.032

156例特应性皮炎患者血清吸入和食物过敏原特异性免疫球蛋白E及患者自觉过敏情况

胡宇晴,张建中

北京大学人民医院皮肤科,北京 100044

收稿日期:2018-12-28 出版日期:2020-10-18 发布日期:2020-10-15
通讯作者: 张建中

Received:2018-12-28 Online:2020-10-18 Published:2020-10-15

摘要/Abstract

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R781.67

胡宇晴,张建中. 156例特应性皮炎患者血清吸入和食物过敏原特异性免疫球蛋白E及患者自觉过敏情况[J]. 北京大学学报（医学版）, 2020, 52(5): 980-984.

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参考文献 10

[1]	Akdis CA, Akdis M, Bieber T, et al. Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report[J]. J Allergy Clin Immunol, 2006,118(1):152-169. doi: 10.1016/j.jaci.2006.03.045 pmid: 16815151
[2]	Wollenberg A, Oranje A, Deleuran M, et al. ETFAD/EADV Eczema task force 2015 position paper on diagnosis and treatment of atopic dermatitis in adult and paediatric patients[J]. J Eur Acad Dermatol Venereol, 2016,30(5):729-747. pmid: 27004560
[3]	Liu P, Zhao Y, Mu ZL, et al. Clinical features of adult/adolescent atopic dermatitis and Chinese criteria for atopic dermatitis[J]. Chin Med J (Engl), 2016,129(7):757-762.
[4]	Hanifin JM. Diagnostic criteria for atopic dermatitis: Consider the context[J]. Arch Dermatol, 1999,135(12):1551. pmid: 10606074
[5]	Darsow U, Vieluf D, Ring J. Evaluating the relevance of aero-allergen sensitization in atopic eczema with the atopy patch test: A randomized, double-blind multicenter study. Atopy Patch Test Study Group[J]. J Am Acad Dermatol, 1999,40(1):187-193. doi: 10.1016/S0190-9622(99)70186-6
[6]	Chu H, Shin JU, Park CO, et al. Clinical diversity of atopic dermatitis: A review of 5 000 patients at a single institute[J]. Allergy Asthma Immunol Res, 2017,9(2):158-168. doi: 10.4168/aair.2017.9.2.158 pmid: 28102061
[7]	Scalabrin DM, Bavbek S, Perzanowski MS, et al. Use of specific IgE in assessing the relevance of fungal and dust mite allergens to atopic dermatitis: A comparison with asthmatic and nonasthmatic control subjects[J]. J Allergy Clin Immunol, 1999,104(6):1273-1279. doi: 10.1016/s0091-6749(99)70024-2 pmid: 10589012
[8]	Celakovská J, Bukac J. Analysis of food allergy in atopic dermatitis patients: Association with concomitant allergic diseases [J]. Indian J Dermatol, 2014,59(5):445-450. doi: 10.4103/0019-5154.139867 pmid: 25284847
[9]	Sampson HA. The evaluation and management of food allergy in atopic dermatitis[J]. Clin Dermatol, 2003,21(3):183-192. doi: 10.1016/s0738-081x(02)00363-2 pmid: 12781436
[10]	Mastrorilli C, Caffarelli C, Hoffmann-Sommergruber K. Food allergy and atopic dermatitis: Prediction, progression and prevention[J]. Pediatr Allergy Immunol, 2017,28(8):831-840. pmid: 29117431

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Allergen	Positive sIgE detection, n(%)
Aeroallergen	61 (39.1)
Dust mites	40 (25.6)
Artemisia	16 (10.3)
Mixture of epithelia	15 (9.6)
Mixed molds	17 (10.9)
Mixed botany	3 (1.9)
Mixed pollens	10 (6.4)
Willow	9 (5.8)
Poplar	6 (3.9)
Food allergen	31 (19.9)
Egg	10 (6.4)
Milk	15 (9.6)
Shrimp	10 (6.4)
Beef	9 (5.8)
Mutton	11 (7.1)
Fish	6 (3.9)
Crab	13 (8.3)
Staple foods	3 (1.9)

Allergen	Subjective causative factors of allergen, n(%)	Positive results of serum sIgE detection, n(%)
Aeroallergen
Dust (dust mites)	42 (26.9)	40 (25.6)
Armoise (artemisia)	17 (10.9)	16 (10.3)
Mixture of epithelia (cat fur or dog fur)	26 (16.7)	15 (9.6)
Cold air	31 (19.9)
Moist environment (mixed molds)	54 (34.6)	17 (10.9)
Botany (including mixed botany, pollens, willow and poplar)	15 (9.6)	28 (18.0)
Furniture	15 (9.6)
Traveling	16 (10.3)
Food allergen
Egg	8 (5.1)	10 (6.4)
Milk	7 (4.5)	15 (9.6)
Shrimp	46 (29.5)	10 (6.4)
Mutton	24 (15.4)	11 (7.1)
Beef	19 (12.2)	9 (5.8)
Fish	35 (22.4)	6 (3.9)
Crab	42 (26.9)	13 (8.3)
Staple foods	2 (1.3)	3 (1.9)
Peanuts	7 (4.5)
Nuts	6 (3.9)
Spicy food	42 (26.9)

Allergen	Serum test accorded with subjective symptoms, n(%)				Serum test disaccorded with subjective symptoms, n(%)
Allergen	Serum test(+)/ Subjective symptoms(+)		Serum test(-)/ Subjective symptoms(-)		Serum test(+)/ Subjective symptoms(-)		Serum test(-)/ Subjective symptoms(+)
Aeroallergen
Dust mites (dust)		18 (11.5)		92 (59.0)		22 (14.1)		24 (15.4)
Artemisia (armoise)		5 (3.2)		128 (82.0)		11 (7.0)		12 (7.7)
Mixture of epithelia (cat fur or dog fur)		8 (5.1)		123 (78.8)		7 (4.5)		18 (11.5)
Mixed molds (moist environment)		10 (6.4)		93 (59.6)		7 (4.5)		45 (28.8)
Mixed botany, pollens, willow or poplar (botany)		3 (1.9)		117 (75.0)		25 (16.0)		12 (7.7)
Food allergen
Egg		3 (1.9)		141 (90.3)		7 (4.5)		5 (3.2)
Milk		4 (2.6)		138 (88.5)		11 (7.0)		3 (1.9)
Shrimp		7 (4.5)		107 (68.6)		3 (1.9)		39 (25.0)
Beef		4 (2.6)		127 (81.4)		5 (3.2)		20 (12.8)
Mutton		4 (2.6)		130 (83.3)		7 (4.5)		15 (9.6)
Fish		3 (1.9)		118 (75.6)		3 (1.9)		32 (20.5)
Crab		10 (6.4)		111 (71.2)		3 (1.9)		32 (20.5)
Staple foods		1 (0.6)		152 (97.4)		2 (1.3)		1 (0.6)

156例特应性皮炎患者血清吸入和食物过敏原特异性免疫球蛋白E及患者自觉过敏情况

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