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北京大学学报（医学版） ›› 2021, Vol. 53 ›› Issue (3): 518-522. doi: 10.19723/j.issn.1671-167X.2021.03.013

• 论著 • 上一篇    下一篇

2015—2017年北京市2型糖尿病患者骨关节炎患病的相关因素

吴俊慧1,陈泓伯1,2,武轶群1,吴瑶1,王紫荆1,吴涛1,王梦莹1,王斯悦1,王小文1,王伽婷1,于欢1,胡永华1,Δ()   

  1. 1.北京大学公共卫生学院流行病与卫生统计学系,北京 100191
    2.北京大学护理学院老年护理与康复教研室,北京 100191
  • 收稿日期:2021-03-01 出版日期:2021-06-18 发布日期:2021-06-16
  • 通讯作者: 胡永华 E-mail:yhhu@bjmu.edu.cn
  • 基金资助:
    国家自然科学基金(81230066);国家自然科学基金(81473043);国家自然科学基金(81703291);国家自然科学基金(81872695)

Prevalence and risk factors of osteoarthritis in patients with type 2 diabetes in Beijing, China from 2015 to 2017

WU Jun-hui1,CHEN Hong-bo1,2,WU Yi-qun1,WU Yao1,WANG Zi-jing1,WU Tao1,WANG Meng-ying1,WANG Si-yue1,WANG Xiao-wen1,WANG Jia-ting1,YU Huan1,HU Yong-hua1,Δ()   

  1. 1. Department of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China
    2. Department of Geriatric Nursing and Rehabilitation, Peking University School of Nursing, Beijing 100191, China
  • Received:2021-03-01 Online:2021-06-18 Published:2021-06-16
  • Contact: Yong-hua HU E-mail:yhhu@bjmu.edu.cn
  • Supported by:
    National Natural Science Foundation of China(81230066);National Natural Science Foundation of China(81473043);National Natural Science Foundation of China(81703291);National Natural Science Foundation of China(81872695)

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摘要：

目的: 利用大数据对2型糖尿病患者骨关节炎的患病情况和相关因素进行探究,为该类合并症的防治工作提供科学依据。方法: 利用2015—2017年北京市所有定点医疗机构的就诊数据,收集成年2型糖尿病患者的相关资料进行描述性分析,采用Logistic回归模型探究2型糖尿病患者骨关节炎患病的相关因素。结果: 共纳入1 046 264例成年2型糖尿病患者,平均年龄63.07岁,男性占50.78%。2型糖尿病患者中患有骨关节炎的病例341 561人,患病率为32.65%;女性患病率(38.05%)高于男性(27.41%),差异有统计学意义(P<0.05)。2型糖尿病患者骨关节炎在各个年龄段均有发生,骨关节炎患病率最高的年龄组为65~69岁组(36.76%),患病率最低的年龄组为≤44岁组(14.3%),70岁前患病率随年龄组的升高而增加。进一步分析2型糖尿病患者骨关节炎患病的影响因素,发现女性(OR=1.62,95%CI:1.61~1.63)、年龄(OR=1.01,95%CI:1.01~1.01)、患有其他合并症(OR=1.19,95%CI:1.18~1.21)、使用降糖药(OR=0.79,95%CI:0.78~0.80)、患有心血管疾病(OR=1.13,95%CI:1.11~1.15)、患有脑血管疾病(OR=1.25,95%CI:1.23~1.28)、患有糖尿病肾病(OR=1.61,95%CI:1.51~1.71)等因素与2型糖尿病人群患骨关节炎有关。结论: 北京地区2型糖尿病患者骨关节炎的患病率较高,应对中老年患者加强健康宣教与疾病监测工作,重点关注绝经期妇女,尽早开展合并症筛查工作。

关键词: 糖尿病,2型, 骨关节炎, 共病现象, 患病率

Abstract:

Objective: To explore the prevalence and related factors of osteoarthritis in patients with type 2 diabetes mellitus, and provided a scientific basis for the prevention of the comorbidity. Methods: The data were obtained from the database of all designated medical institutions in Beijing from 2015 to 2017. Data of the adult patients with type 2 diabetes mellitus were collected for descriptive analysis, and a Logistic regression model was used to explore the related factors of osteoarthritis in the patients with type 2 diabetes mellitus. Results: A total of 1 046 264 diagnosed type 2 diabetes mellitus adult patients were included in our study, with an average age of 63.07 years, and 50.78% were males. Among the patients with type 2 diabetes mellitus, there were 341 561 cases with osteoarthritis, and the prevalence of osteoarthritis was 32.65%. The prevalence of females (38.05%) was higher than that of males (27.41%), and the difference was statistically significant (P<0.05). Osteoarthritis occurred in all age groups among the patients with type 2 diabetes mellitus, with the highest prevalence of osteoarthritis in the age group of 65-69 years (36.76%), and the lowest prevalence in the age group ≤44 years (14.3%). Before the age of 70, the prevalence increased with age. Further analysis of related factors for osteoarthritis in the patients with type 2 diabetes mellitus showed that female (OR=1.62, 95%CI: 1.61-1.63), age (OR=1.01, 95%CI: 1.01-1.01), had other comorbidities (OR=1.19, 95%CI: 1.18-1.21), used hypoglycemic drugs (OR=0.79, 95%CI: 0.78-0.80), having the cardiovascular disease (OR=1.13, 95%CI: 1.11-1.15), having cerebrovascular disease (OR=1.25, 95%CI: 1.23-1.28), and having nephropathy (OR=1.61, 95%CI: 1.51-1.71) were associated with the osteoarthritis in the type 2 diabetic mellitus patients. Conclusion: Our study revealed that the prevalence of osteoarthritis in patients with type 2 diabetes mellitus is high in Beijing area. Health education and disease monitoring should be strengthened in middle-aged and elderly patients. Screening for comorbidities should be carried out as soon as possible, with the focus on menopausal women.

Key words: Diabetes mellitus,type 2, Osteoarthritis, Comorbidity, Prevalence

中图分类号: 

  • R181.3

表1

2015—2017年北京市成年2型糖尿病患者的一般情况"

Characteristics With osteoarthritis(n=341 561) Without osteoarthritis(n=704 703) Total(n=1 046 264)
n % n % n %
Gender
Male 145 615 42.63 385 722 54.74 531 337 50.78
Female 195 946 57.37 318 981 45.26 514 927 49.22
Age group
≤44 years 13 407 3.93 61 650 8.75 75 057 7.17
45-54 years 48 873 14.31 121 812 17.29 170 685 16.31
55-64 years 120 204 35.19 228 786 32.47 348 990 33.36
65-74 years 82 241 24.08 142 097 20.16 224 338 21.44
≥75 years 76 836 22.50 150 358 21.34 227 194 21.71
Comorbidity
Yes 40 387 11.82 94 502 13.41 134 889 12.89
No 301 174 88.18 610 201 86.59 911 375 87.11
Use of hypoglycemic drugs
Yes 257 246 75.31 501 560 71.17 758 806 72.53
No 84 315 24.69 203 143 28.83 287 458 27.47

图1

各年龄段2型糖尿病患者骨关节炎的患病率"

表2

2015—2017年北京市2型糖尿病合并骨关节炎患者其他共病患病率(%)"

Characteristics Age group Total
≤44 years 45-54 years 55-64 years 65-74 years ≥75 years
Cardiovascular disease 7.70 14.57 18.40 24.52 35.36 22.72
Cerebrovascular disease 5.65 9.12 11.02 15.07 24.62 14.57
Nephropathy 3.07 1.62 1.31 1.49 1.72 1.56
Eye diseases 0.97 0.65 0.66 0.68 0.48 0.64

表3

2015—2017年北京成年2型糖尿病患者患骨关节炎相关因素的多因素Logistic回归分析"

Variable Model 1 Model 2 Model 3
OR 95%CI P OR 95%CI P OR 95%CI P
Female 1.63 1.62-1.65 <0.01 1.62 1.61-1.63 <0.01 1.62 1.61-1.63
Age 1.01 1.01-1.02 <0.01 1.02 1.01-1.02 <0.01 1.01 1.01-1.02 <0.01
Comorbidity 1.19 1.18-1.21 <0.01
Use of hypoglycemic drugs 0.79 0.78-0.80 <0.01
Cardiovascular disease 1.13 1.11-1.15 <0.01
Cerebrovascular disease 1.25 1.23-1.28 <0.01
Eye diseases 1.03 0.94-1.13 0.44
Nephropathy 1.61 1.51-1.71 <0.01
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ISSN 1671-167X
CN 11-4691/R
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