北京大学学报(医学版) ›› 2022, Vol. 54 ›› Issue (6): 1229-1233. doi: 10.19723/j.issn.1671-167X.2022.06.029

• 短篇论著 • 上一篇    下一篇

唇腺病理阴性干燥综合征患者的临床特点

李红霞1,周雅馨1,王亚飞2,王鹏宇2,吴振彪2,*()   

  1. 1 空军特色医学中心风湿免疫科,北京 100142
    2 空军军医大学第一附属医院风湿免疫科,西安 710032
  • 收稿日期:2022-08-27 出版日期:2022-12-18 发布日期:2022-12-19
  • 通讯作者: 吴振彪 E-mail:wuzhenbiaoxjimmu@163.com
  • 基金资助:
    国家重点研发计划(201KTCL03_03)

红霞 李1,雅馨 周1,亚飞 王2,鹏宇 王2,振彪 吴2,*()   

  • Received:2022-08-27 Online:2022-12-18 Published:2022-12-19
  • Contact: 振彪 吴 E-mail:wuzhenbiaoxjimmu@163.com
  • Supported by:
    National Key Research Development Program of China(201KTCL03_03)

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关键词: 干燥综合征, 唇腺, 病理阴性

中图分类号: 

  • R593.2

图1

pSS患者不同唇腺病理改变"

表1

唇腺病理阳性与阴性pSS患者临床指标比较"

Variables Positive-pSS (n=104) Negative-pSS (n=113) Statistics P
Age/years, $\bar x \pm s$ 48.5±14.9 49.6±14.2 0.440 0.508
Gender (Males/Females), n 5/99 7/106 0.199 0.655
Duration/months, M(P25, P75) 12 (6, 45) 14 (6, 36) 0.802 0.423
Dry mouth 83 (79.8) 83 (73.4) 1.217 0.270
Dry eyes 62 (59.6) 59 (52.2) 1.203 0.273
Parotid swelling 11 (10.6) 15 (13.3) 0.374 0.541
Rampant caries 22 (21.2) 13 (11.5) 3.728 0.054
Arthralgia/Anthritis 16 (15.4) 28 (24.8) 2.957 0.086
Rash 20 (19.2) 22 (19.5) 0.002 0.965
Fever 5 (4.8) 8 (7.1) 0.496 0.481
Hematological involvement 34 (32.7) 34 (30.1) 0.171 0.680
  Leukocytopenia 29 (27.9) 22 (19.5) 2.133 0.144
  Thrombocytopenia 15 (14.4) 15 (13.3) 0.060 0.807
Interstitial pneumonia 10 (9.6) 10 (8.9) 0.038 0.846
Kidney involvement 7 (6.7) 5 (4.4) 0.551 0.458
Nerve involvement 5 (4.8) 9 (8.0) 0.894 0.344
WUSF rate≤0.1 mL/min 46/69 (66.7) 63/80 (78.8) 2.754 0.097
Schirmer test ≤ 5 mm/5 min 43/69 (62.3) 41/77 (53.2) 1.226 0.268
ESSDAI, $\bar x \pm s$ 6.7±5.4 5.7±4.4 3.486 0.063
  ESSDAI<5 44 (42.3) 51 (45.1) 0.176 0.675
  5≤ESSDAI<10 31 (29.8) 42 (37.2) 1.314 0.252
  ESSDAI≥10 29 (27.9) 20 (17.7) 3.214 0.073

表2

唇腺病理阳性与阴性pSS患者免疫指标比较[n (%)]"

Variables Positive-pSS (n=104) Negative-pSS (n=113) Statistics P
ANA seropositive 101 (97.1) 111 (98.2) 0.009 0.925
  ANA titer = 1 ∶100 6 (5.8) 14 (12.4) 2.837 0.092
  ANA titer = 1 ∶320 9 (8.7) 20 (17.7) 3.723 0.054
  ANA titer = 1 ∶1 000 19 (18.3) 26 (23.0) 0.740 0.390
  ANA titer ≥ 1 ∶3 200 67 (64.4) 51 (45.1) 8.123 0.004
Anti-SSA 86 (82.7) 98 (86.7) 0.683 0.408
Anti-Ro-52 87 (83.7) 90 (79.6) 0.579 0.447
Anti-SSB 48 (46.2) 34 (30.1) 5.946 0.015
AMA-M2 8 (7.7) 15 (13.3) 1.781 0.182
Anti-CENP-B 8 (7.7) 10 (8.9) 0.095 0.757
Anti-RNP/Sm 11 (10.6) 12 (10.6) 0.000 0.992
Anti-dsDNA 0 1 (0.9)
Anti-CCP 1/40 (2.5) 2/43 (4.7) >0.999
IgG>1 600 mg/dL 71/96 (74.0) 60/99 (60.6) 3.941 0.047
IgA>450 mg/dL 18/96 (18.8) 13/99 (13.1) 1.151 0.283
IgM>270 mg/dL 9/96 (9.4) 7/99 (7.1) 0.344 0.558
C3 < 80 mg/dL 43/96 (44.8) 37/97 (38.1) 0.878 0.349
C4 < 16 mg/dL 36/96 (37.5) 33/97 (34.0) 0.254 0.614
RF seropositive 70/96 (72.9) 56/97 (57.7) 4.909 0.027
ESR>20 mm/h 48/83 (57.8) 31/82 (37.8) 6.629 0.010
CRP>0.8 mg/dL 9/94 (9.6) 5/97 (5.2) 1.373 0.241

表3

pSS患者病理阳性相关性因素分析"

Variables OR (95%CI) P value
Rampant caries 1.608 (0.723-3.576) 0.245
ANA titer ≥ 1 ∶3 200 1.592 (0.838-3.025) 0.155
Anti-SSB positive 1.190 (0.616-2.299) 0.604
ESR>20 mm/h 2.239 (0.657-2.337) 0.508
IgG>1 600 mg/dL 1.635 (0.813-3.290) 0.168
RF seropositive 0.875 (0.448-1.710) 0.696
ESSDAI
  ESSDAI < 5 Reference
  5≤ESSDAI < 10 0.711 (0.357-1.419) 0.334
  ESSDAI≥10 1.554 (0.723-3.340) 0.259
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