Journal of Peking University(Health Sciences) ›› 2016, Vol. 48 ›› Issue (3): 502-506. doi: 10.3969/j.issn.1671-167X.2016.03.022

• Article • Previous Articles     Next Articles

Relationship and clinical significance between mutated BRAF with prophylactic central-neck nodal dissection in papillary thyroid carcinoma

ZHANG Yu-jie, LIU Bao-guo△, ZHAO Zhi-yan, SHENG Jin-dong, FENG Dong-dong   

  1. [Department of Head & Neck, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China]
  • Online:2016-06-18 Published:2016-06-18
  • Contact: LIU Bao-guo E-mail:lbg29@163.com
  • Supported by:

    Supported by the National High Technology Research and Development Program of China (863 Program, 2012AA02A202)

Abstract:

Objective: To evaluate the molecular diagnosis marker of papillary thyroid carcinoma (PTC), the relationship between lymphatic metastasis of central neck compartment PTC, and the operation indication of prophylactic central neck dissection. Methods: We conducted a retrospective study, including 275 PTC patients and detected their BRAF mutation rates during 2012 and 2014 and explored the risk factors of the central node lymphatic metastasis by Logistic regression model. Results: Of the 275 PTC patients, 224 (81.5%) were female and 51 (18.5%) were male. BRAF mutational rates were 53.8% (148/275) and lymphatic metastasis 57.8% (159/275). Multivariate analysis showed calcification (ORadjusted=1.47, 95%CI: 1.10-1.98, P=0.01), tumor diameter (ORadjusted=1.48, 95%CI: 1.04-2.30, P=0.048) and age (ORadjusted=1.48, 95%CI: 1.04-2.30, P=0.048) were associa-ted with lymphatic metastasis. In stratified analysis, BRAF mutation (ORadjusted=3.19, 95%CI: 1.18-9.43, P=0.023) in clear boarder group and BRAF mutation (ORadjusted=4.84, 95%CI: 1.68-13.84, P=0.003) in calcification group were more likely to have lymphatic metastases. Conclusion: Central neck metastasis takes up a high ratio in papillary thyroid cancer patients, BRAF mutation in papillary thyroid carcinoma is a characteristic molecular event. Furthermore, patients with calcification under ultrasound detection, lower age group and longer tumor diameter are more susceptible to suffer central neck metastasis. Especially for stratified analysis, non-calcified  BRAF mutation or BRAF mutation with clear border under ultrasound detection are more susceptible to suffer central neck metastasis, and radical prophylactic central neck dissection should be carried on for these patients.

Key words: Thyroid cancer, papillary, Lymphatic metastasis, BRAF, Mutation, Lymph node excision

CLC Number: 

  • R736.1
[1] Yin-ji JIN,Lin SUN,Jin-xia ZHAO,Xiang-yuan LIU. Significance of IgA isotype of anti-v-raf murine sarcoma viral oncogene homologue B1 antibody in rheumatoid arthritis [J]. Journal of Peking University (Health Sciences), 2023, 55(4): 631-635.
[2] Yun-fei SHI,Hao-jie WANG,Wei-ping LIU,Lan MI,Meng-ping LONG,Yan-fei LIU,Yu-mei LAI,Li-xin ZHOU,Xin-ting DIAO,Xiang-hong LI. Analysis of clinicopathological and molecular abnormalities of angioimmunoblastic T-cell lymphoma [J]. Journal of Peking University (Health Sciences), 2023, 55(3): 521-529.
[3] Yan XIONG,Bo ZHANG,Li-gong NIE,Shi-kai WU,Hu ZHAO,Dong LI,Ji-ting DI. Thoracic SMARCA4-deficient undifferentiated tumor-pathological diagnosis and combined immune checkpoint inhibitor treatment [J]. Journal of Peking University (Health Sciences), 2023, 55(2): 351-356.
[4] Qiu-jun ZHOU,Pan GONG,Xian-ru JIAO,Zhi-xian YANG. Clinical and molecular genetic analysis of Angelman syndrome with oculocutaneous albinism type 2: A case report and literature review [J]. Journal of Peking University (Health Sciences), 2023, 55(1): 181-185.
[5] Xiao-jing CHENG,Dong JIANG,Lian-hai ZHANG,Jiang-hua WANG,Ya-zhen LI,Jia-hui ZHAI,Bao-qi YAN,Lu-lu ZHANG,Xing-wang XIE,Zi-yu LI,Jia-fu JI. Preclinical study of T cell receptor specifically reactive with KRAS G12V mutation in the treatment of malignant tumors [J]. Journal of Peking University (Health Sciences), 2022, 54(5): 884-895.
[6] Cai-peng QIN,Yu-xuan SONG,Meng-ting DING,Fei WANG,Jia-xing LIN,Wen-bo YANG,Yi-qing DU,Qing LI,Shi-jun LIU,Tao XU. Establishment of a mutation prediction model for evaluating the efficacy of immunotherapy in renal carcinoma [J]. Journal of Peking University (Health Sciences), 2022, 54(4): 663-668.
[7] Xi CHEN,Si-yue WANG,En-ci XUE,Xue-heng WANG,He-xiang PENG,Meng FAN,Meng-ying WANG,Yi-qun WU,Xue-ying QIN,Jing LI,Tao WU,Hong-ping ZHU,Jing LI,Zhi-bo ZHOU,Da-fang CHEN,Yong-hua HU. Exploring the association between de novo mutations and non-syndromic cleft lip with or without palate based on whole exome sequencing of case-parent trios [J]. Journal of Peking University (Health Sciences), 2022, 54(3): 387-393.
[8] YE Jian-fei,ZHAO Lei,WANG Guo-liang,HONG Kai,MA Lu-lin. Clinical analysis of testicular rhabdomyosarcoma [J]. Journal of Peking University (Health Sciences), 2021, 53(6): 1178-1182.
[9] FENG Ke,NI Jing-jing,XIA Yan-qing,QU Xiao-wei,ZHANG Hui-juan,WAN Feng,HONG Kai,ZHANG Cui-lian,GUO Hai-bin. Genetic analysis of three cases of acephalic spermatozoa syndrome caused by SUN5 mutation and the outcome of assisted reproductive technology [J]. Journal of Peking University (Health Sciences), 2021, 53(4): 803-807.
[10] CAO Ze,WANG Le-tong,LIU Zhen-ming. Homologous modeling and binding ability analysis of Spike protein after point mutation of severe acute respiratory syndrome coronavirus 2 to receptor proteins and potential antiviral drugs [J]. Journal of Peking University (Health Sciences), 2021, 53(1): 150-158.
[11] WU Jun-yi,YU Miao,SUN Shi-chen,FAN Zhuang-zhuang,ZHENG Jing-lei,ZHANG Liu-tao,FENG Hai-lan,LIU Yang,HAN Dong. Detection of EDA gene mutation and phenotypic analysis in patients with hypohidrotic ectodermal dysplasia [J]. Journal of Peking University (Health Sciences), 2021, 53(1): 24-33.
[12] Ying-chao WU,Yun-long CAI,Long RONG,Ji-xin ZHANG,Jin LIU,Xin WANG. Characteristics of lymph node metastasis and evaluating the efficacy of endoscopic submucosal dissection in early gastric cancer [J]. Journal of Peking University (Health Sciences), 2020, 52(6): 1093-1097.
[13] Yi BAO,Juan-fen MO. Concordant point mutation of ETS-related gene (ERG) in tumor tissues from a synchronous multiple primary lung cancer: A case report [J]. Journal of Peking University (Health Sciences), 2020, 52(5): 971-974.
[14] Hao WANG,Yang LIU,Hao-chen LIU,Dong HAN,Hai-lan FENG. Detection and functional analysis of BMP2 gene mutation in patients with tooth agenesis [J]. Journal of Peking University(Health Sciences), 2019, 51(1): 9-15.
[15] Zhu YOU,Li-li XU,Xue-fen LI,Jian-yun ZHANG,Jing DU,Li-sha SUN. BRAF gene mutations in ameloblastic fibromas [J]. Journal of Peking University(Health Sciences), 2019, 51(1): 4-5.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!