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Journal of Peking University (Health Sciences) ›› 2021, Vol. 53 ›› Issue (3): 485-490. doi: 10.19723/j.issn.1671-167X.2021.03.008

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Epidemiological study of infantile epilepsy incidence density among infants under 36 months of age in Ningbo City from 2015 to 2019

YAO Xiao-ying1,LIU Zhi-ke1,LI Ning2,MA Rui2,ZHAO Xue-fei2,ZHANG Liang2,XU Guo-zhang2,ZHAN Si-yan1,Δ(),FANG Ting2,Δ()   

  1. 1. Department of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China
    2. Ningbo Municipal Center for Disease Control and Prevention, Ningbo 315010, Zhejiang, China
  • Received:2021-02-05 Online:2021-06-18 Published:2021-06-16
  • Contact: Si-yan ZHAN,Ting FANG E-mail:siyan-zhan@bjmu.edu.cn;fangt@nbcdc.org.cn
  • Supported by:
    National Natural Science Foundation of China(81973146)

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Abstract:

Objective: To describe the distribution and trend of infantile epilepsy among infants under 36 months in Ningbo, Zhejiang Province. Methods: Using the birth cohort design, we retrospectively collected the local born infants in Ningbo national health information platform from 2015 to 2019, and took the first visit of epilepsy in the electronic medical record of the platform as the new case. The incidence density and 95% confidence interval (CI) of epilepsy were estimated by Poisson distribution. Results: From 2015 to 2019, a total of 294 900 children were born in Ningbo, with male accounting for 51.92%. The total person-years of observation were 595 300, while the median follow-up person-years was 2.31 [interquartile range (IQR): 1.90]. There were 575 new onset epilepsy patients during the whole observation period. The total number of visits was 2 599, with an average of 4.52. The total incidence density was 96.59/100 000 person-years (95%CI: 88.85-104.82). The median age of onset was 13 months (IQR: 15), 0-12 months old infants had the highest incidence density (102.18/100 000 person-years), 25-36 months old infants had the lowest incidence density (89.68/100 000 person-years), and the difference was not statistically significant (P>0.05). The incidence density of male was 97.58/100 000 person-years, female was 95.53/100 000 person-years, and the difference was not statistically significant (P>0.05). Fenghua was the highest (130.54/100 000 person-years, 95%CI: 94.47-175.83) and Ninghai was the lowest (66.44/100 000 person-years, 95%CI: 47.02-91.19), with significant difference (P<0.05). There was no significant difference in the incidence density in different birth years (P>0.05). There was significant difference in the incidence density between 0-12 months old infants in different calendar years (Ptrend<0.05). In this age group, the incidence density was the lowest in 2015 (69.41/100 000 person-years, 95%CI: 41.79-108.39), and the highest in 2019 (225.61/100 000 person-years, 95%CI: 186.10-271.03). There was no significant difference in the incidence density between 13-24 and 25-36 months old infants in different calendar years (P>0.05). Conclusion: The incidence density of epilepsy in 0-36 months old infants in Ningbo City from 2015 to 2019 was low as a whole, and there was no difference in age group, gender, and year of birth. The incidence density of 0-12 months old infants increased with the year.

Key words: Epilepsy, Birth cohort, Incidence density, Epidemiologic study, Infant

CLC Number: 

  • R181.32

Table 1

Demographic characteristics of local population under 36 months old born in Ningbo from 2015 to 2019 [n (%)]"

Variable Total (n=294 938) Male (n=153 137) Female (n=141 801) χ2 P valuea
Person-years 595 307.70 (100.00) 308 476.90 (51.82) 286 830.80 (48.18)
Birth yearb 9.25 >0.05
2015 56 373 (19.11) 29 381 (19.19) 26 992 (19.04)
2016 64 363 (21.82) 33 264 (21.72) 31 099 (21.93)
2017 62 685 (21.25) 32 634 (21.31) 30 051 (21.19)
2018 55 317 (18.76) 28 490 (18.60) 26 827 (18.92)
2019 56 200 (19.05) 29 368 (19.18) 26 832 (18.92)
Birth seasonc 4.82 >0.05
Spring 70 407 (23.87) 36 527 (23.85) 33 880 (23.89)
Summer 73 953 (25.07) 38 457 (25.11) 35 496 (25.03)
Autumn 79 651 (27.01) 41 547 (27.13) 38 104 (26.87)
Winter 70 927 (24.05) 36 606 (23.90) 34 321 (24.20)
Area 36.20 <0.05
Yinzhou 66 036 (22.39) 34 278 (22.38) 31 758 (22.40)
Cixi 40 635 (13.78) 20 916 (13.66) 19 719 (13.91)
Yuyao 35 399 (12.00) 18 448 (12.05) 16 951 (11.95)
Haishu 30 850 (10.46) 15 985 (10.44) 14 865 (10.48)
Ninghai 28 549 (9.68) 15 230 (9.95) 13 319 (9.39)
Beilun 26 062 (8.84) 13 376 (8.73) 12 686 (8.95)
Zhenhai 18 984 (6.44) 9 746 (6.36) 9 238 (6.51)
Xiangshan 17 096 (5.80) 8 880 (5.80) 8 216 (5.79)
Fenghua 16 062 (5.44) 8 413 (5.49) 7 639 (5.39)
Jiangbei 15 233 (5.16) 7 843 (5.12) 7 390 (5.21)
Missing 42 (0.01) 22 (0.01) 20 (0.01)

Table 2

Demographic characteristics of infantile epilepsy onset among patients under 36-months-old from 2015 to 2019"

Variable Total (n=575) Male (n=301) Female (n=274)
Month onset/months, M (IQR) 13 (15) 15 (16) 11 (14)
Age group onset, n(%)
0-12 months 282 (49.04) 133 (44.19) 149 (54.38)
13-24 months 178 (30.96) 103 (34.22) 75 (27.37)
25-36 months 115 (20.00) 65 (21.59) 50 (18.25)
Calendar year onset, n(%)
2015 19 (3.30) 8 (2.66) 11 (4.01)
2016 72 (12.52) 36 (11.96) 36 (13.14)
2017 165 (28.70) 86 (28.57) 79 (28.83)
2018 165 (28.70) 83 (27.57) 82 (29.93)
2019 154 (26.78) 88 (29.24) 66 (24.09)

Figure 1

Diagram of regional characteristics of infantile epilepsy incidence density among infants under 36-month-old from 2015 to 2019 (/100 000 person-years)"

Table 3

Population distribution characteristics of infantile epilepsy incidence density among infants under 36-month-old from 2015 to 2019 (/100 000 person-years)"

Variable Incidence density (95%CI)
Total 96.59 (88.85, 104.82)
Gender
Male 97.58 (86.86, 109.25)
Female 95.53 (84.55, 107.53)
Age group
0-12 months 102.18 (90.60, 114.83)
13-24 months 93.14 (79.96, 107.88)
25-36 months 89.68 (74.04, 107.65)

Table 4

Temporal characteristics of infantile epilepsy incidence density among infants under 36-month-old from 2015 to 2019(/100 000 person-years)"

Age group/
months		 Birth year, incidence density (95%CI) Ptrend
2015 2016 2017 2018 2019
0-12 85.57
(62.87, 113.78)		 115.78
(90.75, 145.57)		 114.12
(88.96, 144.18)		 136.89
(107.49, 171.86)		 65.86
(39.03, 104.09)a		 >0.05
13-24 99.18
(74.07, 130.06)		 93.94
(71.15, 121.70)		 84.78
(62.92, 111.77)		 75.03
(45.18, 117.17)b		 >0.05
25-36 102.46
(76.52, 134.36)		 69.71
(50.02, 94.56)		 79.51
(49.83, 120.37)c		 >0.05
Age group/
months		 Calendar year, incidence density (95%CI) Ptrend
2015 2016 2017 2018 2019
0-12 69.41
(41.79, 108.39)		 89.39
(66.56, 117.53)		 130.01
(103.55, 161.16)		 174.68
(142.28, 212.25)		 225.61
(186.10, 271.03)		 <0.05
13-24 80.70
(49.96, 123.37)		 106.07
(80.54, 137.12)		 92.84
(70.32, 120.28)		 75.28
(54.25, 101.75)		 >0.05
25-36 127.54
(87.24, 180.05)		 73.63
(52.36, 100.66)		 70.13
(50.96, 94.14)		 >0.05
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