北京大学学报(医学版) ›› 2023, Vol. 55 ›› Issue (3): 567-封三. doi: 10.19723/j.issn.1671-167X.2023.03.027

• 综述 • 上一篇    

中国睡眠医学的过去、现在和未来

邓佳慧1,黄筱琳1,刘晓星1,孙杰2,陆林1,3,4,*()   

  1. 1. 北京大学第六医院,北京大学精神卫生研究所,国家卫生健康委员会精神卫生学重点实验室(北京大学),国家精神心理疾病临床医学研究中心(北京大学第六医院),北京 100191
    2. 北京大学第三医院疼痛医学中心,北京 100191
    3. 北京大学前沿交叉学科研究院生命科学联合中心,北京 100871
    4. 北京大学中国药物依赖性研究所,药物依赖性研究北京市重点实验室,北京 100191
  • 收稿日期:2022-07-22 出版日期:2023-06-18 发布日期:2023-06-12
  • 通讯作者: 陆林 E-mail:linlu@bjmu.edu.cn
  • 基金资助:
    国家自然科学基金(82271528)

The past, present and future of sleep medicine in China

Jia-hui DENG1,Xiao-lin HUANG1,Xiao-xing LIU1,Jie SUN2,Lin LU1,3,4,*()   

  1. 1. Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China
    2. Pain Medicine Center, Peking University Third Hospital, Beijing 100191, China
    3. Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China
    4. National Institute on Drug Dependence, Peking University & Beijing Key Laboratory of Drug Dependence Research, Beijing 100191, China
  • Received:2022-07-22 Online:2023-06-18 Published:2023-06-12
  • Contact: Lin LU E-mail:linlu@bjmu.edu.cn
  • Supported by:
    the National Natural Science Foundation of China(82271528)

关键词: 睡眠医学, 睡眠障碍, 中国, 研究进展

Abstract:

Sleep is a highly conserved phenomenon in endotherms, and has a universal physiological function across all species. In mammals, sleep can be divided into two stages: rapid eye movement (REM) sleep and non-REM (NREM) sleep, which alternate in a cyclic manner. Humans spend about one-third of their lives asleep. Sufficient sleep is necessary for humans to sustain everyday functioning. Sleep plays an important role in regulating energy metabolism, immune defense, endocrine function, and the consolidation of memory process. With the development of social economy and the change of life style, sleep duration of the residents has gradually decreased and the incidence of sleep disturbances has increased. Sleep disturbances can lead to severe mental disorders, such as depression, anxiety disorders, dementia, and other mental diseases, and may increase the risk of physical diseases, such as chronic inflammation, heart disease, diabetes, hypertension, atherosclerosis and others. Maintaining good sleep is of great significance for developing social productive forces, promoting sustainable development of economic society, and is a necessary condition for carrying out the "Healthy China Strategy". The sleep research in China started in 1950s. After decades of development, researchers have made great progress in the molecular mechanisms of sleep and wakefulness, the pathogenesis of sleep disorders and the development of new therapies. With the advancement of science and technology and the public's attention to sleep, the level of clinical diagnosis and therapy of sleep disorders in China is gradually brought in line with international standards. The publication of diagnosis and treatment guidelines in the field of sleep medicine will promote the standardization of the construction. In the future, it is still necessary to promote the development of sleep medicine in the following aspects: Strengthening the professional training and discipline construction, improving the cooperation of sleep research, promoting the intelligent diagnosis and treatment of sleep disorders, and developing the new intervention strategies. Therefore, this review will comprehensively summarize the origin, current situation, and future expectations of sleep medicine in China, including discipline construction of sleep medicine, the number of sleep project grants, research findings, the status and progress of diagnosis and treatment of sleep disorders, and the development direction of sleep medicine.

Key words: Sleep medicine, Sleep disorders, China, Research progress

中图分类号: 

  • R338.63
1 Siegel JM . Sleep viewed as a state of adaptive inactivity[J]. Nat Rev Neurosci, 2009, 10 (10): 747- 753.
doi: 10.1038/nrn2697
2 Brandenberger G . Symposium: Normal and abnormal rem sleep regulation: Episodic hormone release in relation to REM sleep[J]. J Sleep Res, 1993, 2 (4): 193- 198.
doi: 10.1111/j.1365-2869.1993.tb00089.x
3 Rasch B , Born J . About sleep's role in memory[J]. Physiol Rev, 2013, 93 (2): 681- 766.
doi: 10.1152/physrev.00032.2012
4 Besedovsky L , Lange T , Haack M . The sleep-immune crosstalk in health and disease[J]. Physiol Rev, 2019, 99 (3): 1325- 1380.
doi: 10.1152/physrev.00010.2018
5 Jahrami HA , Alhaj OA , Humood AM , et al. Sleep disturbances during the COVID-19 pandemic: A systematic review, meta-analysis, and meta-regression[J]. Sleep Med Rev, 2022, 62, 101591.
doi: 10.1016/j.smrv.2022.101591
6 Shi L , Lu ZA , Que JY , et al. Prevalence of and risk factors associated with mental health symptoms among the general population in China during the coronavirus disease 2019 pandemic[J]. JAMA Netw Open, 2020, 3 (7): e2014053.
doi: 10.1001/jamanetworkopen.2020.14053
7 Streatfeild J , Smith J , Mansfield D , et al. The social and econo-mic cost of sleep disorders[J]. Sleep, 2021, 44 (11): zsab132.
doi: 10.1093/sleep/zsab132
8 Ge L , Guyatt G , Tian J , et al. Insomnia and risk of mortality from all-cause, cardiovascular disease, and cancer: Systematic review and meta-analysis of prospective cohort studies[J]. Sleep Med Rev, 2019, 48, 101215.
doi: 10.1016/j.smrv.2019.101215
9 Li L , Gan Y , Zhou X , et al. Insomnia and the risk of hypertension: A meta-analysis of prospective cohort studies[J]. Sleep Med Rev, 2021, 56, 101403.
doi: 10.1016/j.smrv.2020.101403
10 Hertenstein E , Feige B , Gmeiner T , et al. Insomnia as a predictor of mental disorders: A systematic review and meta-analysis[J]. Sleep Med Rev, 2019, 43, 96- 105.
doi: 10.1016/j.smrv.2018.10.006
11 健康中国行动推进委员会. 健康中国行动(2019—2030年)[EB/OL]. (2019-07-09)[2022-05-10]. http://www.gov.cn/xinwen/2019-07/15/content_5409694.htm.
12 刘艳骄, 孙书臣, 洪兰, 等. 中国睡眠医学的过去、现在与未来[J]. 世界睡眠医学杂志, 2014, 1 (1): 6- 11.
13 Karbowski K . Hans Berger (1873-1941)[J]. J Neurol, 2002, 249 (8): 1130- 1131.
doi: 10.1007/s00415-002-0872-4
14 万文鹏. 药物和睡眠[J]. 国际精神病学杂志, 1975, (3): 122- 126.
15 蔡浩然. 睡眠中什么时候做梦[J]. 科学大众, 1964, (6): 237.
16 Van Someren EJW . Brain mechanisms of insomnia: New perspectives on causes and consequences[J]. Physiol Rev, 2021, 101 (3): 995- 1046.
doi: 10.1152/physrev.00046.2019
17 Alonso-Fernandez A , Toledo-Pons N , Garcia-Rio F . Obstructive sleep apnea and venous thromboembolism: Overview of an emerging relationship[J]. Sleep Med Rev, 2020, 50, 101233.
doi: 10.1016/j.smrv.2019.101233
18 邓锐, 金鑫, 贾金忠, 等. 1988—2019年睡眠研究领域国家自然科学基金立项情况分析及未来展望[J]. 中国全科医学, 2022, 25 (14): 1687- 1693.
19 中华人民共和国科学技术部. 《科技部关于发布科技创新2030——"脑科学与类脑研究"重大项目2021年度项目申报指南的通知》[EB/OL]. (2021-09-16)[2022-05-25]. https://service.most.gov.cn/kjjh_tztg_all/20210916/4583.html.
20 Ren S , Wang Y , Yue F , et al. The paraventricular thalamus is a critical thalamic area for wakefulness[J]. Science, 2018, 362 (6413): 429- 434.
doi: 10.1126/science.aat2512
21 Luo YJ , Li YD , Wang L , et al. Nucleus accumbens controls wakefulness by a subpopulation of neurons expressing dopamine D(1) receptors[J]. Nat Commun, 2018, 9 (1): 1576.
doi: 10.1038/s41467-018-03889-3
22 Yang SR , Hu ZZ , Luo YJ , et al. The rostromedial tegmental nucleus is essential for non-rapid eye movement sleep[J]. PLoS Biol, 2018, 16 (4): e2002909.
doi: 10.1371/journal.pbio.2002909
23 Li YD , Luo YJ , Xu W , et al. Ventral pallidal GABAergic neurons control wakefulness associated with motivation through the ventral tegmental pathway[J]. Mol Psychiatry, 2021, 26 (7): 2912- 2928.
doi: 10.1038/s41380-020-00906-0
24 Chen CR , Zhong YH , Jiang S , et al. Dysfunctions of the paraventricular hypothalamic nucleus induce hypersomnia in mice[J]. Elife, 2021, 10, e69909.
doi: 10.7554/eLife.69909
25 Guo F , Holla M , Diaz MM , et al. A circadian output circuit controls sleep-wake arousal in drosophila[J]. Neuron, 2018, 100 (3): 624- 635.e4.
doi: 10.1016/j.neuron.2018.09.002
26 Jing M , Zhang P , Wang G , et al. A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies[J]. Nat Biotechnol, 2018, 36 (8): 726- 737.
doi: 10.1038/nbt.4184
27 Sun F , Zeng J , Jing M , et al. A genetically encoded fluorescent sensor enables rapid and specific detection of dopamine in flies, fish, and mice[J]. Cell, 2018, 174 (2): 481- 496.e19.
doi: 10.1016/j.cell.2018.06.042
28 Feng J , Zhang C , Lischinsky JE , et al. A genetically encoded fluorescent sensor for rapid and specific in vivo detection of norepinephrine[J]. Neuron, 2019, 102 (4): 745- 761.e8.
doi: 10.1016/j.neuron.2019.02.037
29 Ai S , Yin Y , Chen Y , et al. Promoting subjective preferences in simple economic choices during nap[J]. Elife, 2018, 7, e40583.
doi: 10.7554/eLife.40583
30 Liu Y , Lin W , Liu C , et al. Memory consolidation reconfigures neural pathways involved in the suppression of emotional memories[J]. Nat Commun, 2016, 7, 13375.
doi: 10.1038/ncomms13375
31 He J , Sun HQ , Li SX , et al. Effect of conditioned stimulus exposure during slow wave sleep on fear memory extinction in humans[J]. Sleep, 2015, 38 (3): 423- 431.
doi: 10.5665/sleep.4502
32 Zhang Y , Ren R , Lei F , et al. Worldwide and regional prevalence rates of co-occurrence of insomnia and insomnia symptoms with obstructive sleep apnea: A systematic review and meta-analysis[J]. Sleep Med Rev, 2019, 45, 1- 17.
doi: 10.1016/j.smrv.2019.01.004
33 Zhang Y , Ren R , Yang L , et al. Polysomnographic nighttime features of narcolepsy: A systematic review and meta-analysis[J]. Sleep Med Rev, 2021, 58, 101488.
doi: 10.1016/j.smrv.2021.101488
34 Chen SJ , Shi L , Bao YP , et al. Prevalence of restless legs syndrome during pregnancy: A systematic review and meta-analysis[J]. Sleep Med Rev, 2018, 40, 43- 54.
doi: 10.1016/j.smrv.2017.10.003
35 Shi L , Chen SJ , Ma MY , et al. Sleep disturbances increase the risk of dementia: A systematic review and meta-analysis[J]. Sleep Med Rev, 2018, 40, 4- 16.
doi: 10.1016/j.smrv.2017.06.010
36 Zhang Y , Ren R , Yang L , et al. Sleep in Alzheimer's disease: A systematic review and meta-analysis of polysomnographic findings[J]. Transl Psychiatry, 2022, 12 (1): 136.
doi: 10.1038/s41398-022-01897-y
37 Wang Z , Chen WH , Li SX , et al. Gut microbiota modulates the inflammatory response and cognitive impairment induced by sleep deprivation[J]. Mol Psychiatry, 2021, 26 (11): 6277- 6292.
doi: 10.1038/s41380-021-01113-1
38 Zhang Y , Ren R , Sanford LD , et al. Sleep in posttraumatic stress disorder: A systematic review and meta-analysis of polysomnographic findings[J]. Sleep Med Rev, 2019, 48, 101210.
doi: 10.1016/j.smrv.2019.08.004
39 Zhang Y , Ren R , Sanford LD , et al. Sleep in Parkinson's disease: A systematic review and meta-analysis of polysomnogra-phic findings[J]. Sleep Med Rev, 2020, 51, 101281.
doi: 10.1016/j.smrv.2020.101281
40 Ai S , Zhang J , Zhao G , et al. Causal associations of short and long sleep durations with 12 cardiovascular diseases: Linear and nonlinear Mendelian randomization analyses in UK Biobank[J]. Eur Heart J, 2021, 42 (34): 3349- 3357.
doi: 10.1093/eurheartj/ehab170
41 Li Y , Vgontzas AN , Fernandez-Mendoza J , et al. Insomnia with physiological hyperarousal is associated with hypertension[J]. Hypertension, 2015, 65 (3): 644- 650.
doi: 10.1161/HYPERTENSIONAHA.114.04604
42 Ren R , Li Y , Zhang J , et al. Obstructive sleep apnea with objective daytime sleepiness is associated with hypertension[J]. Hypertension, 2016, 68 (5): 1264- 1270.
doi: 10.1161/HYPERTENSIONAHA.115.06941
43 Ren R , Covassin N , Zhang Y , et al. Interaction between slow wave sleep and obstructive sleep apnea in prevalent hypertension[J]. Hypertension, 2020, 75 (2): 516- 523.
doi: 10.1161/HYPERTENSIONAHA.119.13720
44 Zhang X , Wang S , Xu H , et al. Metabolomics and microbiome profiling as biomarkers in obstructive sleep apnoea: A comprehensive review[J]. Eur Respir Rev, 2021, 30 (160): 200220.
doi: 10.1183/16000617.0220-2020
45 Guan J , Yi H , Zou J , et al. Distinct severity stages of obstructive sleep apnoea are correlated with unique dyslipidaemia: Large-scale observational study[J]. Thorax, 2016, 71 (4): 347- 355.
doi: 10.1136/thoraxjnl-2015-207403
46 Jhuang YH , Chung CH , Wang ID , et al. Association of obstructive sleep apnea with the risk of male infertility in Taiwan[J]. JAMA Netw Open, 2021, 4 (1): e2031846.
doi: 10.1001/jamanetworkopen.2020.31846
47 Babiloni AH , Bellemare A , Beetz G , et al. The effects of non-invasive brain stimulation on sleep disturbances among different neurological and neuropsychiatric conditions: A systematic review[J]. Sleep Med Rev, 2021, 55, 101381.
doi: 10.1016/j.smrv.2020.101381
48 Wang HX , Wang L , Zhang WR , et al. Effect of transcranial alternating current stimulation for the treatment of chronic insomnia: A randomized, double-blind, parallel-group, placebo-controlled clinical trial[J]. Psychother Psychosom, 2020, 89 (1): 38- 47.
doi: 10.1159/000504609
49 Shamim-Uzzaman QA , Bae CJ , Ehsan Z , et al. The use of telemedicine for the diagnosis and treatment of sleep disorders: An American Academy of Sleep Medicine update[J]. J Clin Sleep Med, 2021, 17 (5): 1103- 1107.
doi: 10.5664/jcsm.9194
50 Roenneberg T . Chronobiology: The human sleep project[J]. Nature, 2013, 498 (7455): 427- 428.
doi: 10.1038/498427a
[1] 王婷,李乔晟,刘皓冉,简伟研. 人格特征、城乡差异与抑郁症状变化的关系[J]. 北京大学学报(医学版), 2023, 55(3): 385-391.
[2] 曹瑞洁,姚中强,焦朋清,崔立刚. 不同分类标准对中国大动脉炎的诊断效能比较[J]. 北京大学学报(医学版), 2022, 54(6): 1128-1133.
[3] 陆林,刘晓星,袁凯. 中国脑科学计划进展[J]. 北京大学学报(医学版), 2022, 54(5): 791-795.
[4] 方伟岗,田新霞,解云涛. 基因多态性对中国汉族女性乳腺癌遗传易感性的影响[J]. 北京大学学报(医学版), 2022, 54(5): 822-828.
[5] 刘小璇,段晓慧,张朔,孙阿萍,张英爽,樊东升. 中国人群遗传性周围神经病的致病基因分布[J]. 北京大学学报(医学版), 2022, 54(5): 874-883.
[6] 张力,龚继芳,潘宏铭,白玉贤,刘天舒,程颖,陈亚池,黄佳莹,许婷婷,葛飞娇,许婉玲,施佳,胡夕春,沈琳. 阿替利珠单抗治疗中国晚期实体瘤患者的开放标签Ⅰ期临床试验[J]. 北京大学学报(医学版), 2022, 54(5): 971-980.
[7] 梁喆,范芳芳,张岩,秦献辉,李建平,霍勇. 中国高血压人群中H型高血压的比率和特征及与美国人群的比较[J]. 北京大学学报(医学版), 2022, 54(5): 1028-1037.
[8] 许颖,次仁央金. 高原红细胞增多症与消化性溃疡出血的关系[J]. 北京大学学报(医学版), 2022, 54(1): 161-165.
[9] 敖英芳. 我国运动医学发展与北京冬奥会和健康中国建设[J]. 北京大学学报(医学版), 2021, 53(5): 823-827.
[10] 郭应禄. 夯实人才培养,实现我国泌尿外科奋斗目标[J]. 北京大学学报(医学版), 2021, 53(4): 633-634.
[11] 王志成,郭岩. 中国社区社会经济地位和成人自评健康的关联研究[J]. 北京大学学报(医学版), 2021, 53(2): 314-319.
[12] 王一帆,范稹,成姚斌,金月波,霍阳,何菁. 原发性干燥综合征患者睡眠障碍的相关影响因素[J]. 北京大学学报(医学版), 2020, 52(6): 1063-1068.
[13] 康玉琦,张月苗,侯平,师素芳,刘立军,周绪杰,吕继成,张宏. IgA肾病易感基因遗传多态性的种族差异分析[J]. 北京大学学报(医学版), 2019, 51(3): 459-466.
[14] 陆林. 中国精神卫生学科发展的回顾与展望[J]. 北京大学学报(医学版), 2019, 51(3): 379-383.
[15] 徐小凤,陈茜,赵艺璞,胡秀英. 我国西部地区居家老年人生活自理能力调查分析[J]. 北京大学学报(医学版), 2018, 50(3): 457-462.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] 张三. 中文标题测试[J]. 北京大学学报(医学版), 2010, 42(1): 1 -10 .
[2] 田增民, 陈涛, Nanbert ZHONG, 李志超, 尹丰, 刘爽. 神经干细胞移植治疗遗传性小脑萎缩的临床研究(英文稿)[J]. 北京大学学报(医学版), 2009, 41(4): 456 -458 .
[3] 郭岩, 谢铮. 用一代人时间弥合差距——健康社会决定因素理论及其国际经验[J]. 北京大学学报(医学版), 2009, 41(2): 125 -128 .
[4] 成刚, 钱振华, 胡军. 艾滋病项目自愿咨询检测的技术效率分析[J]. 北京大学学报(医学版), 2009, 41(2): 135 -140 .
[5] 赵磊, 王天龙 . 右心室舒张末期容量监测用于肝移植术中容量管理的临床研究[J]. 北京大学学报(医学版), 2009, 41(2): 188 -191 .
[6] 袁惠燕, 张苑, 范田园. 离子交换型栓塞微球及其载平阳霉素的制备与性质研究[J]. 北京大学学报(医学版), 2009, 41(2): 217 -220 .
[7] 徐莉, 孟焕新, 张立, 陈智滨, 冯向辉, 释栋. 侵袭性牙周炎患者血清中抗牙龈卟啉单胞菌的IgG抗体水平的研究[J]. 北京大学学报(医学版), 2009, 41(1): 52 -55 .
[8] 祁琨, 邓芙蓉, 郭新彪. 纳米二氧化钛颗粒对人肺成纤维细胞缝隙连接通讯的影响[J]. 北京大学学报(医学版), 2009, 41(3): 297 -301 .
[9] 万有, , 韩济生, John E. Pintar. 孤啡肽基因敲除小鼠电针镇痛作用增强[J]. 北京大学学报(医学版), 2009, 41(3): 376 -379 .
[10] 张燕, 韩志慧, 钟延丰, 王盛兰, 李玲玲, 郑丹枫. 骨骼肌活组织检查病理诊断技术的改进及应用[J]. 北京大学学报(医学版), 2009, 41(4): 459 -462 .