微量泵脉冲输注戈那瑞林治疗垂体柄中断综合征性腺功能减退病例分析及文献回顾

北京大学学报（医学版） ›› 2014, Vol. 46 ›› Issue (4): 642-645.

微量泵脉冲输注戈那瑞林治疗垂体柄中断综合征性腺功能减退病例分析及文献回顾

邵为民1, 2，白文俊1△，陈益民3，刘磊4，王玉杰2△

（1.北京大学人民医院泌尿外科，北京100044；2.新疆医科大学第一附属医院泌尿中心，乌鲁木齐830054；3.广东省潮州市人民医院泌尿外科，广东潮州521000；4河南省郑州市第一人民医院泌尿外科，郑州450004）

出版日期:2014-08-18 发布日期:2014-08-18

Micropump infusion of gonadorelin in the treatment of hypogonadotropic hypogonadism in patients with pituitary stalk interruption syndrome: cases analysis and literature review

SHAO Wei-min1, 2，BAI Wen-jun1△,CHEN Yi-min3，LIU Lei4，WANG Yu-jie2△

（1.Department of Urology, Peking University People’s Hospital, Beijing 10044,China; 2.Center of Urology,The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China; 3.Department of Urology, Chaozhou People’s Hospital, Guangdong Chaozhou 521000,China; 4.Department of Urology, The First Hospital of Zhengzhou, Henan, Zhengzhou 450004, China）

Online:2014-08-18 Published:2014-08-18

摘要/Abstract

摘要： 本文报道2例微量泵脉冲输注戈那瑞林治疗垂体柄中断综合征导致的性腺功能减退患者，总结2例患者的临床特征及接受微量泵脉冲输注戈那瑞林治疗12周的效果。2例患者均以低促性性腺功能减退为主要表现，经微量泵脉冲输注戈那瑞林治疗12周，雄激素缺乏症状改善，性腺激素水平上升。微量泵脉冲输注戈那瑞林可作为治疗垂体柄中断综合征导致的性腺功能减退的一种选择。

关键词: 性腺功能减退症, 垂体, 促性腺激素释放激素, 输注泵

Abstract: Two cases of hypogonadotropic hypogonadism caused by pituitary stalk interruption syndrome treated by pulse infusion of gonadorelin via micropump were reported, and their clinical features and the treatment process of pulse infusion of gonadorelin via micropump summarized. Both of the 2 patients were presented primarily with hypogonadotropic hypogonadism. After the treatment with pulse infusion of gonadorelin via micropump, their syndrome of androgen deficiency improved and the gonadotropin levels promoted at the end of 12 weeks’ follow-up. Pulse infusion of gonadorelin via micropump is an alternative to treat hypogonadotropic hypogonadism caused by pituitary stalk interruption syndrome.

Key words: Hypogonadism, Pituitary gland, Gonadotropin-releasing hormone, Infusion pumps

邵为民, 白文俊, 陈益民, 刘磊, 王玉杰. 微量泵脉冲输注戈那瑞林治疗垂体柄中断综合征性腺功能减退病例分析及文献回顾[J]. 北京大学学报（医学版）, 2014, 46(4): 642-645.

SHAO Wei-Min, BAI Wen-Jun, CHEN Yi-Min, LIU Lei, WANG Yu-Jie. Micropump infusion of gonadorelin in the treatment of hypogonadotropic hypogonadism in patients with pituitary stalk interruption syndrome: cases analysis and literature review[J]. Journal of Peking University(Health Sciences), 2014, 46(4): 642-645.

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