北京大学学报(医学版) ›› 2018, Vol. 50 ›› Issue (6): 986-990. doi: 10.19723/j.issn.1671-167X.2018.06.008
Yu-hua WANG,Guo-hua ZHANG,Ling-ling ZHANG,Jun-li LUO,Lan GAO,Mian-song ZHAO()
摘要:
目的: 对合并恶性肿瘤的类风湿关节炎患者74例的临床特征进行分析。方法: 回顾总结首都医科大学附属北京世纪坛医院2011年1月至2017年6月住院治疗的1 562例类风湿关节炎患者,对其中74例类风湿关节炎合并恶性肿瘤的患者的一般情况、所患肿瘤类型、类风湿关节炎和肿瘤起病顺序、用药情况等进行分析。结果: 类风湿关节炎患者恶性肿瘤的发病率为4.16%,74例患者中女性53例,男性21例。类风湿关节炎发病时年龄(52.6 ± 17.8) 岁,肿瘤确诊时年龄(63.4±12.7)岁。类风湿关节炎起病时间早于恶性肿瘤者51例(51/74),时间间隔2~60年,平均(17.2±14.2)年;恶性肿瘤发病早于类风湿关节炎者16例(16/74),时间间隔1~21年,平均(6.2±5.9)年,其中10例为性激素相关的肿瘤;二者同时发病7例(7/74),两者发生时间间隔在1年以内,7例均为RA先诊断,年龄均在60岁以上,且均为消化道肿瘤。肿瘤类型以胃肠道肿瘤、乳腺癌和生殖系统肿瘤最常见;其次为呼吸系统肿瘤、泌尿系统肿瘤和血液系统肿瘤。结论: 类风湿关节炎患者合并恶性肿瘤的风险增加,病情活动、药物的使用、雌激素及吸烟等是可能的危险因素,因此所有类风湿关节炎患者在诊断时均要进行恶性肿瘤筛查,诊断后要进行恶性肿瘤监测。
中图分类号:
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