外周血淋巴细胞亚群监测对复发转移性乳腺癌的预测及预后价值

doi:10.3969/j.issn.1671-167X.2016.02.023

北京大学学报(医学版) ›› 2016, Vol. 48 ›› Issue (2): 304-309. doi: 10.3969/j.issn.1671-167X.2016.02.023

外周血淋巴细胞亚群监测对复发转移性乳腺癌的预测及预后价值

邵彬，李惠平△，邸立军，宋国红，姜晗昉，梁旭，王超颖，严颖，林晓琳，王丽娜，宛凤玲，
袁艳华，尤渺宁

（北京大学临床肿瘤学院，北京肿瘤医院暨北京市肿瘤防治研究所乳腺肿瘤内科，恶性肿瘤发病机制及转化研究
教育部重点实验室，北京100142）

出版日期:2016-04-18 发布日期:2016-04-18
通讯作者: 李惠平 E-mail:huipingli2012@hotmail.com

Predictive and prognostic value of monitoring lymphocyte subsets in peripheral blood before and after chemotherapy in patients with metastatic breast cancer

SHAO Bin, LI Hui-ping△， DI Li-jun, SONG Guo-hong, JIANG Han-fang, LIANG Xu, WANG Chao-ying, YAN Ying, LIN Xiao-lin, WANG Li-na, WAN Feng-ling, YUAN Yan-hua, YOU Miao-ning

［Department of Medical Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China］

Online:2016-04-18 Published:2016-04-18
Contact: LI Hui-ping E-mail:huipingli2012@hotmail.com

摘要/Abstract

摘要：

目的：检测化疗前、化疗2周期评价疗效时复发转移性乳腺癌患者外周血淋巴细胞亚群比率，探讨外周血淋巴细胞亚群比率与患者化疗近期疗效及预后的关系。方法：采用流式细胞术检测83例复发转移性乳腺癌患者化疗前、化疗2周期评价疗效时外周血中CD3+ T细胞、CD3+/CD4+ T细胞、CD3+/CD8+ T细胞、CD3-/CD16+56+自然杀伤细胞（natural killer，NK）细胞、 CD3+/CD16+56+ T细胞、CD19+ B细胞、CD4+/CD25+调节性T细胞（regulatory T cells，Treg）细胞、CD8+/CD28- T细胞和CD8+/CD28+ T细胞比率，结合临床病理进行统计。结果：疾病控制患者（部分缓解+稳定）化疗后CD4+/CD25+ Treg细胞比率变化较疾病进展患者显著下降（P=0.034）。化疗后Treg细胞比率变化显著影响患者总生存期（P<0.05），化疗后Treg细胞比率降低的患者较升高的患者总生存期显著延长，分别为23.5及9.4个月。结论：复发转移性乳腺癌患者化疗后Treg细胞比率降低者化疗近期疗效及预后较好。

关键词: 乳腺肿瘤, 肿瘤转移, 淋巴细胞亚群, 预后

Abstract:

Objective：To detect the proportion of lymphocyte subsets in peripheral blood of the advanced breast cancer patients before and after chemotherapy with docetaxel and thiotepa, as well as the association between the proportion of peripheral blood lymphocyte subsets with the response rate and prognosis. Methods: The proportions of lymphocyte subsets (CD3+ T cell, CD3+/CD4+ T cell, CD3+/CD8+ T cell, CD3-/CD16+56+ NK cell, CD3+/CD16+56+ T cell, CD19+ B cell, CD4+/CD25+ T cell, CD8+/CD28- T cell, CD8+/CD28+ T cell) in the peripheral blood of 86 patients were analyzed with flowcytometry before and after chemotherapy. The result was analyzed in combination with clinicopathological data. Results: The proportion of regulatory T cells (Treg) after chemotherapy in the disease control patients decreased significantly compared with that of the progressive patients (P=0.034). The difference of the proportions of Treg before and after chemotherapy affected significantly the overall survi-val (OS). The OS of the patients with decreased proportion of Treg was significantly longer than that of the patients with increased proportion of Treg, which was 23.5 and 9.4 months respectively (P<0.05). Conclusion: The patients with decreased proportion of Treg after chemotherapy had higher response rate and better survival benefit.

Key words: Breast neoplasms, Neoplasm metastasis, Lymphocyte subsets, Prognosis

中图分类号:

R737.9

邵彬，李惠平，邸立军，宋国红,姜晗昉，梁旭，王超颖，严颖，林晓琳，王丽娜，宛凤玲，. 外周血淋巴细胞亚群监测对复发转移性乳腺癌的预测及预后价值[J]. 北京大学学报(医学版), 2016, 48(2): 304-309.

SHAO Bin, LI Hui-ping， DI Li-jun, SONG Guo-hong, JIANG Han-fang, LIANG Xu, WANG Chao-ying, YAN Ying, LIN Xiao-lin, WANG Li-na, WAN Feng-ling, YUAN Yan-hua, YOU Miao-ning. Predictive and prognostic value of monitoring lymphocyte subsets in peripheral blood before and after chemotherapy in patients with metastatic breast cancer[J]. Journal of Peking University(Health Sciences), 2016, 48(2): 304-309.

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外周血淋巴细胞亚群监测对复发转移性乳腺癌的预测及预后价值

Predictive and prognostic value of monitoring lymphocyte subsets in peripheral blood before and after chemotherapy in patients with metastatic breast cancer

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