北京大学学报(医学版) ›› 2021, Vol. 53 ›› Issue (2): 413-416. doi: 10.19723/j.issn.1671-167X.2021.02.030

• 短篇论著 • 上一篇    下一篇

沙利度胺治疗原发性干燥综合征合并轻中度非特异性间质性肺炎疗效观察

杨群智,张舸(),费雅楠,付爽,闫冰   

  1. 北京市海淀医院,北京大学第三医院海淀院区风湿免疫科,北京 100080
  • 收稿日期:2019-09-09 出版日期:2021-04-18 发布日期:2021-04-21
  • 通讯作者: 张舸 E-mail:yuncheng1973@163.com

  • Received:2019-09-09 Online:2021-04-18 Published:2021-04-21

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关键词: 沙利度胺, 干燥综合征, 非特异性间质性肺炎

中图分类号: 

  • R593.2

表1

两组患者治疗前后肺功能比较"

Group FVC% FEV1% DLco%
Before treatment After treatment Before treatment After treatment Before treatment After treatment
Control (n=23) 74.99±2.13 75.99±1.95* 72.82±1.91 74.17±2.12* 62.75±1.89 67.43±2.75*
Observation (n=26) 73.37±2.39 77.55±2.43*# 72.65±1.48 75.91±1.49*# 62.64±2.24 69.34±1.96*#

表2

两组治疗前后肺部高分辨率CT的Warrick评分比较"

Group Before treatment After treatment
Control (n=23) 9.18±2.75 7.91±2.52*
Observation (n=26) 8.88±2.89 6.33±2.46*#

表3

两组治疗前后LCQ评分比较"

Group Physiology Psychology
Before treatment After treatment Before treatment After treatment
Control (n=23) 5.37±0.46 5.66±0.45* 5.29±0.52 5.53±0.51*
Observation (n=26) 5.33±0.45 5.94±0.40*# 5.18±0.41 5.85±0.36*#
Group Sociology Total score
Before treatment After treatment Before treatment After treatment
Control (n=23) 5.33±0.46 5.54±0.50* 15.99±1.15 16.74±1.17*
Observation (n=26) 5.19±0.39 5.85±0.34*# 15.71±1.13 17.63±0.93*#

表4

两组患者用药后不良反应发生情况比较"

Groupa Leukopenia Stomach upset Neurosensory abnormality Constipation Drowsiness
Control (n=22) 0 2 (9.1) 0 1 (4.5) 0
Observation (n=25) 1 (4.0) 2 (8.0) 1 (4.0) 3 (1.2) 6 (2.4)*
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