北京大学学报(医学版) ›› 2021, Vol. 53 ›› Issue (4): 811-813. doi: 10.19723/j.issn.1671-167X.2021.04.033

• 病例报告 • 上一篇    下一篇

肾移植术后双侧乳头状肾癌1例

洪鹏1,田晓军1,赵小钰1,杨飞龙1,刘茁1,陆敏2,赵磊1,Δ(),马潞林1,Δ()   

  1. 1.北京大学第三医院 泌尿外科, 北京 100191
    2.北京大学第三医院 病理科,北京 100191
  • 收稿日期:2021-03-14 出版日期:2021-08-18 发布日期:2021-08-25
  • 通讯作者: 赵磊,马潞林 E-mail:bysyzhaolei@163.com;malulin@medmail.com.cn
  • 基金资助:
    北京大学第三医院临床重点项目(BYSYZD2019032)

Bilateral papillary renal cell carcinoma following kidney transplantation: A case report

HONG Peng1,TIAN Xiao-jun1,ZHAO Xiao-yu1,YANG Fei-long1,LIU Zhuo1,LU Min2,ZHAO Lei1,Δ(),MA Lu-lin1,Δ()   

  1. 1. Department of Urology, Peking University Third Hospital, Beijing 100191, China
    2. Department of Pathology, Peking University Third Hospital, Beijing 100191, China
  • Received:2021-03-14 Online:2021-08-18 Published:2021-08-25
  • Contact: Lei ZHAO,Lu-lin MA E-mail:bysyzhaolei@163.com;malulin@medmail.com.cn
  • Supported by:
    Key Clinical Projects of Peking University Third Hospital(BYSYZD2019032)

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关键词: 肾移植, 双侧肾癌, 乳头状肾癌, 手术治疗

Abstract:

With the continuous development of kidney transplantation technique, the survival time after kidney transplantation is gradually prolonged. Thus, the malignant tumor has been the important influencing factor on the long-term survival for kidney transplantation patients. Renal cell carcinoma is a relatively common tumor after kidney transplantation. Besides, clear cell renal cell carcinoma and papillary renal cell carcinoma are the relatively common pathological types for renal cell carcinoma following kidney transplantation. However, bilateral renal cell carcinoma following kidney transplantation is comparatively rare. In this article, we presented a case of bilateral papillary renal cell carcinoma, which occurred after kidney transplantation. And the diagnosis and treatment were introduced in detail. The patient was 37 years old, and he underwent kidney transplantation 13 years ago in our hospital, because of kidney failure. After kidney transplantation, he had regular medical check-up every year. In this year, his urological ultrasound results indicated bilateral renal tumors. And then, he received abdominal and pelvic computed tomography, and the result also showed bilateral renal tumors, which were likely to be malignant tumors. After adequate consultation, the patient chose surgical treatment. The patient received long-term immunosuppressive therapy, because of kidney transplantation. Considering this, the surgeon decided to choose a staging surgical treatment, in order to reduce the bad influence of one-stage surgery. Then, the patient first underwent retroperitoneal laparoscopic radical nephrectomy for right renal tumor in our hospital, and he had no complications after operation. The pathological results showed papillary renal cell carcinoma. He was discharged successfully. He underwent retroperitoneal laparoscopic radical nephrectomy for left renal tumor in our hospital one month later, and he had no complications after operation. The pathological results also showed papillary renal cell carcinoma. He was discharged successfully two days after surgery. In the 3-month follow-up, the patient was recovering well. To sum up, the incidence of bilateral renal cell carcinoma following kidney transplantation is relatively rare, and bilateral radical nephrectomy is effective and safe treatment. Above all, it is the patient’s condition that determines the choice of staging surgery or simultaneous surgery.

Key words: Kidney transplantation, Bilateral renal cell carcinoma, Papillary renal cell carcinoma, Surgical treatment

中图分类号: 

  • R737.11

图1

双肾肾癌CT图"

[1] Briggs JD. Causes of death after renal transplantation [J]. Nephrol Dial Transplant, 2001, 16(8):1545-1549.
doi: 10.1093/ndt/16.8.1545
[2] Végso G, Tóth M, Hídvégi M, et al. Malignancies after renal transplantation during 33 years at a single center [J]. Pathol Oncol Res, 2007, 13(1):63-69.
doi: 10.1007/BF02893443
[3] Kasiske BL, Snyder JJ, Gilbertson DT, et al. Cancer after kidney transplantation in the United States [J]. Am J Transplant, 2004, 4(6):905-913.
doi: 10.1111/ajt.2004.4.issue-6
[4] Collett D, Mumford L, Banner NR, et al. Comparison of the incidence of malignancy in recipients of different types of organ: a UK registry audit [J]. Am J Transplant, 2010, 10(8):1889-1896.
doi: 10.1111/j.1600-6143.2010.03181.x pmid: 20659094
[5] Engels EA, Pfeiffer RM, Fraumeni JF, et al. Spectrum of cancer risk among US solid organ transplant recipients [J]. JAMA, 2011, 306(17):1891-1901.
doi: 10.1001/jama.2011.1592 pmid: 22045767
[6] 张健, 马麟麟, 解泽林, 等. 我国肾移植术后新发恶性肿瘤总结分析 [J]. 中华器官移植杂志, 2014, 35(12):705-710.
[7] Karami S, Yanik EL, Moore LE, et al. Risk of renal cell carcinoma among kidney transplant recipients in the United States [J]. Am J Transplant, 2016, 16(12):3479-3489.
doi: 10.1111/ajt.13862 pmid: 27160653
[8] Apel H, Walschburger-Zorn K, Häberle L, et al. De novo malignancies in renal transplant recipients: experience at a single center with 1 882 transplant patients over 39 yr [J]. Clin Transplant, 2013, 27(1):E30-E36.
doi: 10.1111/ctr.2013.27.issue-1
[9] Choyke PL. Acquired cystic kidney disease [J]. Eur Radiol, 2000, 10(12):1716-1721.
doi: 10.1007/s003300000601
[10] Hoshida Y, Nakanishi H, Shin M, et al. Renal neoplasias in patients receiving dialysis and renal transplantation: clinico-pathological features and p53 gene mutations [J]. Transplantation, 1999, 68(3):385-390.
pmid: 10459542
[11] Leveridge M, Musquera M, Evans A, et al. Renal cell carcinoma in the native and allograft kidneys of renal transplant recipients [J]. J Urol, 2011, 186(1):219-223.
doi: 10.1016/j.juro.2011.03.032 pmid: 21575970
[12] Ishikawa I, Honda R, Yamada Y, et al. Renal cell carcinoma detected by screening shows better patient survival than that detected following symptoms in dialysis patients [J]. Ther Apher Dial, 2004, 8(6):468-473.
pmid: 15663546
[13] Klatte T, Seitz C, Waldert M, et al. Features and outcomes of renal cell carcinoma of native kidneys in renal transplant recipients [J]. BJU Int, 2010, 105(9):1260-1265.
doi: 10.1111/bju.2010.105.issue-9
[14] Gigante M, Neuzillet Y, Patard JJ, et al. Renal cell carcinoma (RCC) arising in native kidneys of dialyzed and transplant patients: are they different entities [J]. BJU Int, 2012, 110(11Pt B):E570-E573.
doi: 10.1111/bju.2012.110.issue-11b
[15] Wang B, Gong H, Zhang X, et al. Bilatetal synchronous sporadic renal cell carcinoma: retroperitoneoscopic strategies and intermediate outcomes of 60 patients [J]. PLoS One, 2016, 11(5):e154578.
[16] Rothman J, Crispen PL, Wong YN, et al. Pathologic concordance of sporadic synchronous bilateral renal mases [J]. Urology, 2008, 72(1):138-142.
doi: 10.1016/j.urology.2008.01.043 pmid: 18336882
[17] Becker F, Siemer S, Tzavaras A, et al. Long-term survival in bilateral renal cell carcinoma: a retrospective single-institutional analysis of 101 patients after surgical treatment [J]. Urology, 2008, 72(2):349-353.
doi: 10.1016/j.urology.2008.04.001 pmid: 18485459
[18] Lowrance WT, Yee DS, Maschino AC, et al. Developments in the surgical management of sporadic synchronous bilateral renal tumours [J]. BJU Int, 2010, 105(8):1093-1097.
doi: 10.1111/j.1464-410X.2009.08844.x pmid: 19751262
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