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北京大学学报（医学版） ›› 2025, Vol. 57 ›› Issue (5): 859-863. doi: 10.19723/j.issn.1671-167X.2025.05.008

• 工作综述 • 上一篇    下一篇

唾液微生态在口腔及全身疾病早期防治中的应用

孙翔宇, 袁超, 周芯竹, 刁婧, 郑树国*()   

  1. 北京大学口腔医学院·口腔医院口腔预防科, 国家口腔医学中心, 国家口腔疾病临床医学研究中心, 口腔生物材料和数字诊疗装备国家工程研究中心, 北京 100081
  • 收稿日期:2025-08-06 出版日期:2025-10-18 发布日期:2025-09-04
  • 通讯作者: 郑树国
  • 基金资助:
    国家重点研发计划(2022YFA1206100); 国家重点研发计划(2022YFE0118300); 国家自然科学基金(81801037); 首都卫生发展科研专项(首发2022-2G-4105)

Application of salivary micro-ecosystem in early prevention and control of oral and systemic diseases

Xiangyu SUN, Chao YUAN, Xinzhu ZHOU, Jing DIAO, Shuguo ZHENG*()   

  1. Department of Preventive Dentistry, Peking University School and Hospital of Stomatology & National Center for Stomato-logy & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Device, Beijing 100081, China
  • Received:2025-08-06 Online:2025-10-18 Published:2025-09-04
  • Contact: Shuguo ZHENG
  • Supported by:
    the National Key R&D Program of China(2022YFA1206100); the National Key R&D Program of China(2022YFE0118300); the National Natural Science Foundation of China(81801037); the Capital' s Funds for Health Improvement and Research(首发2022-2G-4105)

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摘要： 唾液是口腔中蕴含丰富生物学标志物的重要体液, 其内含的微生态在口腔疾病的早期诊断和监测中具有重要价值; 同时, 唾液自身具有取样简便、无痛无创、支持重复取样的独有优势, 因此非常适合用于疾病监测与随访研究。北京大学口腔医学院口腔预防医学课题组开展的系列研究工作中, 通过基于蛋白质/多肽组学和微生物组学等不同组学技术分析, 将不同节段以及不同取样方法所采集唾液样本进行对比, 以探索唾液的稳定性; 同时以龋病、牙周病为代表的口腔疾病以及2型糖尿病、慢性肾病等为代表的全身系统性疾病为切入点, 明确了唾液生物学标志物在疾病早期防治中的重要应用价值。

关键词: 唾液, 微生态系统, 多组学, 生物学标志物, 早期诊断

Abstract: Saliva is an important body fluid in the oral cavity containing lots of biomarkers, whose inherent micro-ecosystem holds significant value for early diagnosis and monitoring of oral diseases. Simultaneously, saliva has particular advantages, such as ease of sampling, painless and non-invasive collection, and suitability for repeated sampling, making it highly appropriate for surveillance and follow-up of diseases. In a series of studies conducted by the research group for preventive dentistry in Peking University School and Hospital of Stomatology, we compared different segments of saliva and those samples collected via different sampling methods using proteomic/peptidomic and microbiomic technologies to explore the stability of saliva samples. Besides, the significance of applying representative salivary biomarkers in early prevention and control of representative oral diseases (e.g. dental caries, periodontal diseases) and systemic conditions (e.g. type 2 diabetes mellitus, chronic kidney disease) was confirmed as well.

Key words: Saliva, Micro-ecosystem, Multiomics, Biomarkers, Early diagnosis

中图分类号: 

  • R781
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ISSN 1671-167X
CN 11-4691/R
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