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Journal of Peking University (Health Sciences) ›› 2025, Vol. 57 ›› Issue (5): 841-846. doi: 10.19723/j.issn.1671-167X.2025.05.005

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Establishment and application of key technologies for periodontal tissue regeneration based on microenvironment and stem cell regulation

Baojin MA1,2, Jianhua LI1,3, Yuanhua SANG4, Yang YU1, Jichuan QIU4, Jinlong SHAO1, Kai LI3, Shiyue LIU1, Mi DU1, Lingling SHANG1, Shaohua GE1,*()   

  1. 1. Department of Periodontology, School and Hospital of Stomatology, Shandong University, Jinan 250012, China
    2. Department of Tissue Engineering and Regeneration, School and Hospital of Stomatology, Shandong University, Jinan 250012, China
    3. Department of Biomaterials, School and Hospital of Stomatology, Shandong University & Shandong Key Laboratory of Oral Diseases & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan 250012, China
    4. State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, China
  • Received:2025-08-06 Online:2025-10-18 Published:2025-08-13
  • Contact: Shaohua GE
  • Supported by:
    the National Natural Science Foundation of China(82320108004); the National Natural Science Foundation of China(81873716); the National Natural Science Foundation of China(81670993); the National Natural Science Foundation of China(81901010); the National Natural Science Foundation of China(81901009); the National Natural Science Foundation of China(82471030); the National Natural Science Foundation of China(82470981); Excellent Young Scholars Fund (Overseas) of the National Natural Science Foundation of China; National Clinical Key Specialty (Periodontology) Construction Project; Construction Engineering Special Fund of "Taishan Scholars" of Shandong Province(tstp20250510)

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Abstract: The prevalence of periodontitis in China is as high as 74.2%, making it the leading cause of tooth loss in adults and severely impacting both oral and overall health. The treatment of periodontitis and periodontal tissue regeneration are global challenges of significant concern. GE Shaohua' s group at School and Hospital of Stomatology, Shandong University has focused on the key scientific issue of "remodeling the periodontal inflammatory microenvironment and optimizing tissue repair and regeneration". They have elucidated the mechanisms underlying the persistence of periodontitis, developed bioactive materials to enhance stem cell regenerative properties, and constructed a series of guided tissue regeneration barrier membranes to promote periodontal tissue repair, leading to the establishment of a comprehensive technology system for the treatment of periodontitis. Specific achievements and progress include: (1) Elucidating the mechanism by which key periodontal pathogens evade antimicrobial autophagy, leading to inflammatory damage; developing intelligent antimicrobial hydrogels and nanosystems, and creating metal-polyphenol network microsphere capsules to reshape the periodontal inflammatory microenvironment; (2) Explaining the mechanisms by which nanomaterial structures and electroactive interfaces regulate stem cell behavior, developing optimized nanostructures and electroactive biomaterials, thereby effectively enhancing the regenerative repair capabilities of stem cells; (3) Creating a series of biphasic heterogeneous barrier membranes, refining guided tissue regeneration and in situ tissue engineering techniques, stimulating the body' s intrinsic repair potential, and synergistically promoting the structural regeneration and functional reconstruction of periodontal tissues. The research outcomes of the group have innovated the fundamental theories of periodontal tissue regeneration, broken through foreign technological barriers and patent blockades, established a cascade repair strategy for periodontal regeneration, and enhanced China' s core competitiveness in the field of periodontal tissue regeneration.

Key words: Periodontitis, Microenvironment, Stem cells, Bioactive materials, Periodontal tissue regeneration

CLC Number: 

  • R781.4
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