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北京大学学报（医学版） ›› 2025, Vol. 57 ›› Issue (5): 864-867. doi: 10.19723/j.issn.1671-167X.2025.05.009

• 获奖工作综述 • 上一篇    下一篇

胃癌精准诊疗技术的创建与推广

李浙民1, 季加孚2,*(), 李国新3, 李子禹1, 步召德1, 高翔宇2, 董迪4, 唐磊5, 邢晓芳6, 贾淑芹7, 郭婷8, 张连海1, 陕飞1, 季鑫1, 王安强1   

  1. 1. 北京大学肿瘤医院暨北京市肿瘤防治研究所胃肠肿瘤中心, 北京 100142
    2. 北京大学肿瘤医院暨北京市肿瘤防治研究所胃肠肿瘤中心, 消化系肿瘤整合防治全国重点实验室, 北京 100142
    3. 清华大学附属北京清华长庚医院胃肠外科, 北京 102218
    4. 中国科学院分子影像重点实验室, 中国科学院自动化研究所, 北京 100190
    5. 北京大学肿瘤医院暨北京市肿瘤防治研究所医学影像科, 北京 100142
    6. 北京大学肿瘤医院暨北京市肿瘤防治研究所胃肠肿瘤转化研究实验室, 消化系肿瘤整合防治全国重点实验室, 北京 100142
    7. 北京大学肿瘤医院暨北京市肿瘤防治研究所分子诊断中心, 消化系肿瘤整合防治全国重点实验室, 北京 100142
    8. 北京大学肿瘤医院暨北京市肿瘤防治研究所胃肠肿瘤转化研究实验室, 恶性肿瘤发病机制及转化研究教育部重点实验室, 北京 100142
  • 收稿日期:2025-08-01 出版日期:2025-10-18 发布日期:2025-08-28
  • 通讯作者: 季加孚
  • 基金资助:
    国家自然科学基金(92259302); 国家自然科学基金(31870805); 国家自然科学基金(U20A20371); 北京市医院管理中心人才计划(DFL20181103); 北京市医院管理中心人才计划(SML20151001); 北京市科技计划课题(D171100006517000); 北京市科技计划课题(D171100006517004)

Development and dissemination of precision medicine approaches in gastric cancer management

Zhemin LI1, Jiafu JI2,*(), Guoxin LI3, Ziyu LI1, Zhaode BU1, Xiangyu GAO2, Di DONG4, Lei TANG5, Xiaofang XING6, Shuqin JIA7, Ting GUO8, Lianhai ZHANG1, Fei SHAN1, Xin JI1, Anqiang WANG1   

  1. 1. Gastrointestinal Cancer Center, Peking University Cancer Hospital & Institute, Beijing 100142, China
    2. Gastrointestinal Cancer Center, Peking University Cancer Hospital & Institute, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing 100142, China
    3. Department of Gastrointestinal Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China
    4. CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
    5. Department of Medical Imaging, Peking University Cancer Hospital & Institute, Beijing 100142, China
    6. Gastrointestinal Cancer Translational Research Laboratory, Peking University Cancer Hospital & Institute, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing 100142, China
    7. Molecular Diagnostic Center, Peking University Cancer Hospital & Institute, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing 100142, China
    8. Gastrointestinal Cancer Translational Research Laboratory, Peking University Cancer Hospital & Institute, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Beijing 100142, China
  • Received:2025-08-01 Online:2025-10-18 Published:2025-08-28
  • Contact: Jiafu JI
  • Supported by:
    the National Natural Science Foundation(92259302); the National Natural Science Foundation(31870805); the National Natural Science Foundation(U20A20371); the Beijing Hospitals Authority Talent Plan(DFL20181103); the Beijing Hospitals Authority Talent Plan(SML20151001); the Beijing Municipal Science and Technology Plan Projects(D171100006517000); the Beijing Municipal Science and Technology Plan Projects(D171100006517004)

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摘要： 胃癌是严重威胁我国居民健康的高发恶性肿瘤, 发病率和死亡率均居前三位, 且多数患者确诊时已属进展期, 治疗难, 预后差。为攻克我国胃癌诊疗中的关键问题, 由北京大学肿瘤医院季加孚教授领衔的科研团队聚焦"胃癌精准诊疗技术的创建与推广"项目, 通过系列多中心、高水平临床研究, 建立了围术期综合治疗、个体化药物筛选、智能无创诊断、新型免疫治疗等多个方面的国际新标准, 显著提高了疗效, 降低了创伤, 从诊断、治疗、机制等多个方面实现胃癌精准诊疗技术领域的关键技术突破, 系统性地改善了胃癌的治疗效果。研究成果在国际上产生了广泛影响, 主办了中国首次国际胃癌大会, 通过全国范围内推广, 促进了胃癌精准诊疗的学科建设, 主持制定了国家卫生健康委员会胃癌诊疗指南, 该项目荣获2024年中华医学科技奖医学科学技术奖一等奖。

关键词: 胃癌, 新辅助化疗, 腹腔镜手术, 人工智能, 免疫疗法

Abstract: Gastric cancer is a high-incidence malignancy that poses a serious threat to public health in China, ranking among the top three cancers in both incidence and mortality. The majority of patients are diagnosed at an advanced stage, resulting in limited treatment options and poor prognosis. To address key challenges in gastric cancer diagnosis and treatment, a research team led by Professor Jiafu Ji at Peking University Cancer Hospital has focused on the project "Development and Dissemination of Precision Medicine Approaches in Gastric Cancer Management". Through a series of high-quality multicenter clinical studies, the team established a set of new international standards in perioperative treatment, individua-lized drug selection, intelligent noninvasive diagnostics, and novel immunotherapy strategies. These advances have significantly improved treatment efficacy and reduced surgical trauma, achieving key technological breakthroughs in diagnosis, therapy, and mechanistic understanding, and systematically enhancing outcomes for gastric cancer patients. The project ' s findings had a broad international impact, including hosting China ' s first International Gastric Cancer Congress. Through nationwide dissemination, they have promoted the development of precision diagnosis and treatment of gastric cancer as a discipline, and led the formulation of the National Health Commission's guidelines for gastric cancer diagnosis and treatment. In recognition of its achievements, the project was awarded the First Prize of the 2024 Chinese Medical Science and Technology Award.

Key words: Gastric cancer, Neoadjuvant chemotherapy, Laparoscopic surgery, Artificial intelligence, Immunotherapy

中图分类号: 

  • R735.2
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ISSN 1671-167X
CN 11-4691/R
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