关键词: 乳头状肾细胞癌, 癌栓, 生存率

Abstract: Objective： To investigate the clinicopathological features，treatment and prognosis of patients with papillary renal cell carcinoma (PRCC) and PRCC-complicated with tumor thrombus. Me-thods: Single center retrospective analysis of 75 patients with PRCC treated from January 2012 to October 2017 was performed. There were 55 males and 20 females at an age range of 24-82 years. Sixteen PRCC patients were complicated with tumor thrombus. All the patients were with a surgery and had clear pathological diagnosis and detailed follow-up data. The clinicopathological features，prognosis and influencing factors of the patients with PRCC and PRCC complicated with tumor thrombus were analyzed and summarized. Results: The average age of the 75 patients was（56.05±11.59）years，the average body mass index (BMI) was （26±3） kg/m2， and the average tumor maximum diameter was（5.17±3.85）cm. There were significant differences between tumor maximum diameter larger than 7 cm and less than 7 cm （69.6% vs. 94.4%， P<0.001）， lymph node metastasis and no lymph node metastasis （<38% vs. 98%， P<0.001）， adrenal metastasis and no adrenal metastasis （0% vs. 95.3%， P<0.001）， pulmonary metastasis and no pulmonary metastasis （0% vs.90.7%， P<0.001）， complicated with and without tumor thrombus （<66.4% vs. 93.5%， P<0.001） on the effect of 3-year survival rate of the PRCC patients. In this study， there were 16 patients with type 2 PRCC complicated with tumor thrombus. There were significant differences in concomitant symptoms （62.5% vs. 22.0%， P=0.005）， maximum tumor diameter （68.8% vs.13.3%， P<0.001）， adrenal metastasis （18.8% vs. 0.02%， P=0.029）， pulmonary metastasis （18.8% vs. 0%， P=0.008）， nuclear grade （P<0.001） and pathological type （100% vs. 44.1%， P<0.001） between the PRCC patients with  and  without tumor thrombus. Conclusion: There were significant differences in tumor diameter，lymph node metastasis，adrenal metastasis，pulmonary metastasis，pathological type，nuclear grade and tumor thrombus in the effect of the 3year survival rate of PRCC patients. PRCC patients with tumor thrombus were more commonly suffered from type 2 PRCC， for whom the tumor diameter was larger，the nuclear grade was higher，and the distance metastasis happened more easily.

Key words: Papillary renal cell carcinoma, Tumor thrombus, Survival rate