北京大学学报(医学版) ›› 2022, Vol. 54 ›› Issue (6): 1238-1243. doi: 10.19723/j.issn.1671-167X.2022.06.031

• 短篇论著 • 上一篇    

敲减CMTM3增加急性B淋巴细胞白血病细胞对伊马替尼敏感性

刘媛1,2,原婉琼3,李婷1,2,王平章1,2,吕平1,2,吴利新4,阮国瑞4,韩文玲1,2,莫晓宁2,*()   

  1. 1 北京大学基础医学院免疫学系,北京 100191
    2 北京大学人类疾病基因研究中心,北京 100191
    3 北京大学第三医院骨科,北京 100191
    4 北京大学人民医院血液科,北京 100044
  • 收稿日期:2020-06-15 出版日期:2022-12-18 发布日期:2022-12-19
  • 通讯作者: 莫晓宁 E-mail:moxiaoning@bjmu.edu.cn
  • 基金资助:
    国家自然科学基金(81971472);北京市自然科学基金(7202081)

媛 刘1,2,婉琼 原3,婷 李1,2,平章 王1,2,平 吕1,2,利新 吴4,国瑞 阮4,文玲 韩1,2,晓宁 莫2,*()   

  • Received:2020-06-15 Online:2022-12-18 Published:2022-12-19
  • Contact: 晓宁 莫 E-mail:moxiaoning@bjmu.edu.cn
  • Supported by:
    the National Natural Science Foundation of China(81971472);Beijing Natural Science Foundation(7202081)

RICH HTML

  

关键词: CMTM3, 急性B淋巴细胞白血病, 伊马替尼, 细胞增殖, Wnt信号通路

中图分类号: 

  • R733.7

图1

CMTM3在B-ALL患者和细胞系中表达上调"

图2

敲减CMTM3能够抑制B-ALL细胞增殖"

图3

敲减CMTM3促进细胞凋亡,但不影响细胞周期"

图4

敲减CMTM3增加B-ALL细胞对伊马替尼敏感性"

图5

敲减CMTM3抑制Wnt信号通路活化"

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