关键词: 前列腺癌, 去势抵抗性, 肿瘤转移, 多西他赛, 泼尼松, 治疗结果

Abstract:

Objective：To investigate the factors that may predict the effectiveness of metastatic castration resistant prostate cancer (mCRPC) patients who received docetaxel plus prednisone treatment. Methods:We retrospectively collected the clinical data of mCRPC patients who has received docetaxel chemotherapy in Peking University First Hospital between February 2010 and March 2015, and the clinical factors were analyzed using univariate analysis. Results:A total of 60 cases of patients were treated, of whom 33 with complete clinical data were analyzed. PSA responsive was defined as PSA declining ≥50% of baseline and without progression according to RESCIST criteria. The median PSA at chemotherapy was 153.4 μg/L (6.6-9 952.0 μg/L), and a total of 20 cases (60.6%) were PSA responsive. Univariate analysis found that lower Gleason score (Gleason scores≤7) (25% vs.72%, P=0.034), the existence of positive Lymph node (78% vs. 40%, P=0.032), the existence of visceral metastasis (80% vs. 44%, P=0.041) and baseline blood HGB value≤120 g/L (30% vs. 74%, P=0.024) were associated with chemotherapy effectiveness.Conclusion:High Gleason score, lymph node metastasis, visceral metastasis and normal HGB level may predict PSA response after docetaxelbased chemotherapy.

Key words: Prostatic neoplasms, castration-resistant, Neoplasm metastasis, Docetaxel, Prednisone, Treatment outcome