北京大学学报(医学版) ›› 2024, Vol. 56 ›› Issue (3): 456-461. doi: 10.19723/j.issn.1671-167X.2024.03.012

• 论著 • 上一篇    下一篇

北京市老年人认知功能的影响因素

林郁婷1,王华丽2,田宇3,巩俐彤4,常春1,*()   

  1. 1. 北京大学公共卫生学院社会医学与健康教育系,北京 100191
    2. 北京大学第六医院记忆障碍诊疗与研究中心/国家精神心理疾病临床医学研究中心,北京 100191
    3. 北京市新街口社区卫生服务中心,北京 100035
    4. 北京市大兴区疾病预防控制中心,北京 102699
  • 收稿日期:2024-02-18 出版日期:2024-06-18 发布日期:2024-06-12
  • 通讯作者: 常春 E-mail:changchun@bjmu.edu.cn
  • 基金资助:
    中国社区卫生协会社区卫生科研基金(20212041)

Factors influencing cognitive function among the older adults in Beijing

Yuting LIN1,Huali WANG2,Yu TIAN3,Litong GONG4,Chun CHANG1,*()   

  1. 1. Department of Social Medicine and Health Education, Peking University School of Public Health, Beijing 100191, China
    2. Peking University Sixth Hospital Dementia Care and Research Center/National Clinical Research Center for Psychiatric Diseases, Beijing 100191, China
    3. Beijing Xinjiekou Community Health Service Center, Beijing 100035, China
    4. Beijing Daxing District Center for Disease Control and Prevention, Beijing 102699, China
  • Received:2024-02-18 Online:2024-06-18 Published:2024-06-12
  • Contact: Chun CHANG E-mail:changchun@bjmu.edu.cn
  • Supported by:
    China Community Health Association Community Health Research Fund(20212041)

RICH HTML

  

摘要:

目的: 探讨老年人认知功能现况,基于生命历程理论分析老年人认知功能的影响因素。方法: 采用横断面研究,于2023年对北京市西城区、大兴区部分老年人进行问卷调查,使用香港简短认知功能检测(Hong Kong brief cognitive test,HKBC)量表评估老年人的认知功能,采用SPSS 27.0软件对老年人认识功能的影响因素进行描述性分析和多元线性回归分析。结果: 纳入349名老年人,年龄在60~69岁的调查对象占比最高(41.3%),58.7%为女性,文化程度初中及以上者占比88.0%,退休前每周工作时长多集中在35~48 h(68.8%),14.0%的老年人有痴呆家族史。在控制年龄、性別等变量后,线性回归分析结果显示,婚姻状况为已婚(β=0.501,95%CI:0.144~0.859)和每周运动3~4次是老年人认知功能的保护因素(β=0.617,95%CI:0.087~1.148),抑郁症状是其危险因素(β=-0.723,95%CI:-1.198~-0.247)。结论: 从生命全周期的视角看待认知功能影响因素,缺乏体育锻炼与抑郁症状均是认知功能的危险因素,加强体育锻炼,改善老年人心理健康,将预防性干预关口前移,有助于预防和减缓老年人认知功能衰退。

关键词: 认知障碍, 危险因素, 老年人, 生命历程理论

Abstract:

Objective: To explore the current status of cognitive function of the older adults in Beijing, and to analyze the factors affecting their cognitive function. Methods: It was a cross-sectional study. A questionnaire survy was conducted in 2023 among the older adults in Beijing. The cognitive function of the older adults was assessed with the Hong Kong brief cognitive test (HKBC) scale, a simple cognitive assessment tool. Using SPSS 27.0 to perform the descriptive analysis and multiple linear regression analysis of factors, which affect cognitive function among the older adults. Results: Totally 349 older adults were recruited, with the highest percentage of respondents aged 60-69 years (41.3%), of whom 58.7% were female, 88.0% of the respondents had a junior high school or above education level. Most of the older adults (68.8%) worked 35-48 h/week before they retired, and 14.0% of the older adults had a family history of dementia. After controlling age and gender, the linear regression analysis showed that marital status married (β=0.501, 95%CI: 0.144-0.859) and 3-4 times physical activity per week (β=0.617, 95%CI: 0.087-1.148) were protective factors of cognitive function in the older adults, and depressive symptoms were a risk factor (β= -0.723, 95%CI: -1.198 to -0.247) of cognitive function for the older adults. Conclusion: In this study, the factors influencing cognitive function among the older adults was analyzed based on a life-cycle perspective. Lack of physical activity and depressive symptoms were risk factors for cognitive function among the older adults. It was suggested that strengthening physical activity, improving mental health of the older adults, as well as conducting preventive intervention in early stages of the life-cycle will be benefit for preventing and slowing cognitive decline in the older adults.

Key words: Cognition disorders, Risk factors, Aged, Life course theory

中图分类号: 

  • R395.6

表1

研究对象的社会人口学特征(n=349)"

Items n(%)
Gender
  Male 144 (41.3)
  Female 205 (58.7)
Age/years
  60- 144 (41.3)
  70- 101 (28.9)
  ≥80 104 (29.8)
Marital status
  Single/Divorced/Widowed 186 (53.3)
  Married 163 (46.7)
Education level
  Primary school or less 42 (12.0)
  Middle school 178 (51.0)
  High school or higher 129 (37.0)
Family history of dementia
  Yes 49 (14.0)
  No 300 (86.0)
Weekly working hours before retirement
  <35 56 (16.0)
  35- 122 (35.0)
  41- 118 (33.8)
  ≥49 53 (15.2)

表2

认知功能得分的单因素分析"

Variable Cognitive function score ($\bar x \pm s$) t/F P
Early life course factors
  Education level 3.872 0.022
    Primary school or below 23.76±1.61
    Middle school 24.25±1.65
    High school or above 24.51±1.34
  Family history of dementia 0.751 0.455
    No 24.31±1.57
    Yes 24.14±1.46
Midlife course factors
  Weekly working hours before retirement 1.998 0.114
    <35 23.89±1.85
    35- 24.32±1.42
    41- 24.49±1.57
    ≥49 24.19±1.40
  Marital status -3.331 0.001
    Single/Divorced/Widowed 24.04±1.66
    Married 24.58±1.36
Late life course factors
  Times of physical activity per week 6.872 0.001
    0-2 23.97±1.81
    3-4 24.76±0.88
    ≥5 24.49±1.34
  Smoking 0.105 0.917
    Never 24.29±1.58
    Everyday/Quit 24.27±1.34
  Drinking -0.997 0.321
    No 24.26±1.61
    Yes 24.44±1.11
  Social participation -1.037 0.300
    Low level 24.21±1.69
    High level 24.38±1.36
  3H 1.038 0.304
    No 24.31±1.59
    Yes 24.09±1.38
  Depression 3.759 <0.001
    No 24.42±1.32
    Yes 23.59±2.33
  Insomnia 2.486 0.013
    No 24.46±1.36
    Yes 24.04±1.77
  Social support 0.503 0.615
    Low level 24.33±1.50
    High level 24.24±1.61

表3

认知功能相关因素的多元回归分析"

VariablesModel 1 Model 2 Model 3
β(95%CI) t P β(95%CI) t P β(95%CI) t P
Sociodemographic factors
  Gender (Female) 0.119(-0.211, 0.450) 0.710 0.478 0.077(-0.254, 0.407) 0.457 0.648 0.015(-0.316, 0.345) 0.088 0.930
Early life course factors
  Education level
    Middle school 0.469(-0.054, 0.992) 1.762 0.079 0.344(-0.191, 0.879) 1.265 0.207 0.309(-0.264, 0.881) 1.061 0.289
    High school or above 0.756(0.205, 1.308) 2.699 0.007 0.479(-0.089, 1.048) 1.658 0.098 0.325(-0.286, 0.935) 1.045 0.297
  Family history of dementia (Yes) -0.133(-0.606, 0.341) -0.550 0.582 -0.131(-0.605, 0.343) -0.542 0.588 -0.107(-0.579, 0.365) -0.446 0.656
Midlife course factors
  Weekly working hours before retirement
    35-40 0.353(-0.137, 0.842) 1.418 0.157 0.270(-0.216, 0.756) 1.094 0.275
    41-48 0.526(0.034, 1.018) 2.105 0.036 0.341(-0.153, 0.836) 1.359 0.175
    ≥49 0.344(-0.263, 0.950) 1.115 0.266 0.126(-0.482, 0.734) 0.407 0.684
  Marital status (Married) 0.539(-0.183, 0.896) 2.978 0.003 0.501(0.144, 0.859) 2.759 0.006
Late life course factors
  Times of physical activity per week
    3-4 0.617(0.087, 1.148) 2.291 0.023
    ≥5 0.270(-0.109, 0.649) 1.402 0.162
  Smoking (Everyday/Quit) -0.119(-0.629, 0.391) -0.458 0.647
  Drinking (Yes) -0.002(-0.472, 0.467) -0.009 0.993
  Social participation (High level) 0.228(-0.131, 0.588) 1.250 0.212
  3H (Yes) -0.205(-0.754, 0.344) -0.735 0.463
  Depression (Yes) -0.723(-1.198, -0.247) -2.991 0.003
  Insomnia (Yes) -0.129(-0.475, 0.217) -0.736 0.462
  Social support (High level) -0.222(-0.574, 0.129) -1.245 0.214
1 Scheltens P , Strooper B , Kivipelto M , et al.Alzheimer's disease[J].Lancet,2021,397(10284):1577-1590.
doi: 10.1016/S0140-6736(20)32205-4
2 王丹, 刘跃华, 朱学敏, 等.WHO和25个国家(地区)应对失智症行动计划及其对我国的启示[J].中国全科医学,2022,25(25):3075-3082.
3 Rtersen RC .Mild cognitive impairment as a diagnostic entity[J].Intern Med,2004,25(6):183-194.
4 Jia L , Du Y , Chu L , et al.Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: A cross-sectional study[J].Lancet Public health,2020,5(12):e661-e671.
doi: 10.1016/S2468-2667(20)30185-7
5 World Health Organization. Global status report on the public health response to dementia[R]. Geneva: World Health Organization, 2021.
6 Ben-Shlomo Y , Kuh D .A life course approach to chronic disease epidemiology: Conceptual models, empirical challenges and interdisciplinary perspectives[J].Int J Epidemiol,2022,31(2):285-293.
7 Livingston G , Huntley J , Sommerlad A , et al.Dementia prevention, intervention, and care: 2020 report of the Lancet Commission[J].Lancet,2020,396(10248):413-446.
doi: 10.1016/S0140-6736(20)30367-6
8 World Health Organization. World report on ageing and health[R]. Geneva: World Health Organization, 2015.
9 付志强, 齐伟, 翁华, 等.关于社会处方管理模式对社区老年人认知状况的干预效果及其社会支持影响因素的探索性研究[J].老龄科学研究,2022,10(12):24-33.
10 Zhou L , Ma X , Wang W .Relationship between cognitive perfor-mance and depressive symptoms in Chinese older adults: The China Health and Retirement Longitudinal Study (CHARLS)[J].J Affect Disord,2021,281,454-458.
doi: 10.1016/j.jad.2020.12.059
11 肖水源.《社会支持评定量表》的理论基础与研究应用[J].临床精神医学杂志,1994,(2):98-100.
12 Chiu HF , Zhong BL , Leung T , et al.Development and validation of a new cognitive screening test: The Hong Kong Brief Cognitive Test (HKBC)[J].Int J Geriatr Psychiatry,2018,33(7):994-999.
doi: 10.1002/gps.4883
13 Andresen EM , Malmgren JA , Carter WB , et al.Screening for depression in well older adults: Evaluation of a short form of the CES-D (Center for Epidemiologic Studies depression scale)[J].Am J Prev Med,1994,10(2):77-78.
doi: 10.1016/S0749-3797(18)30622-6
14 张宝山, 李娟.简版流调中心抑郁量表在全国成年人群中的信效度[J].中国心理卫生杂志,2011,25(7):506-511.
15 Chung KF , Kan KKK , Yeung WF .Assessing insomnia in adolescents: Comparison of insomnia severity index, Athens insomnia scale and sleep quality index[J].Sleep Med,2011,12(5):463-470.
16 于恩彦.中国老年期痴呆防治指南(2021)[M].北京: 人民卫生出版社,2021.
17 Baumgart M , Snyder HM , Carrillo MC , et al.Summary of the evidence on modifiable risk factors for cognitive decline and demen-tia: A population-based perspective[J].Alzheimers Dement,2015,11(6):718-726.
18 Sanders LM , Hortobagyi T , Gemert SB , et al.Dose-response relationship between exercise and cognitive function in older adults with and without cognitive impairment: A systematic review and meta-analysis[J].PLoS One,2019,14(1):e0210036.
19 Erickson KI , Hillman C , Stillman CM , et al.Physical activity, cognition, and brain outcomes: A review of the 2018 physical activity guidelines[J].Med Sci Sports Exerc,2019,51(6):1242-1251.
20 Wit LD , O'Shea D , Chandler M , et al.Physical exercise and cognitive engagement outcomes for mild neurocognitive disorder: A group-randomized pilot trial[J].Trials,2018,19(1):1-11.
21 James SN , Chiou YJ , Fatih N , et al.Timing of physical activity across adulthood on later-life cognition: 30 years follow-up in the 1946 British birth cohort[J].J Neurol Neurosurg Psychiatry,2023,94(5):349-356.
22 Prince M, Albanese E, Guerchet M. World Alzheimer Report 2014: Dementia and risk reduction. An analysis of protective and modifiable risk factors[R]. London: Alzheimer Disease International, 2014.
23 Chen H , Zhou YG , Huang LY , et al.Multimorbidity burden and developmental trajectory in relation to later-life dementia: A prospective study[J].Alzheimers Dement,2023,19(5):2024-2033.
[1] 刘园梅, 傅义程, 郝靖欣, 张福春, 刘慧琳. 老年髋部骨折患者住院期间发生术后心力衰竭的列线图预测模型的构建及验证[J]. 北京大学学报(医学版), 2024, 56(5): 874-883.
[2] 李志存, 吴天俣, 梁磊, 范宇, 孟一森, 张骞. 穿刺活检单针阳性前列腺癌术后病理升级的危险因素分析及列线图模型构建[J]. 北京大学学报(医学版), 2024, 56(5): 896-901.
[3] 颜野,李小龙,夏海缀,朱学华,张羽婷,张帆,刘可,刘承,马潞林. 前列腺癌根治术后远期膀胱过度活动症的危险因素[J]. 北京大学学报(医学版), 2024, 56(4): 589-593.
[4] 陈延,李况蒙,洪锴,张树栋,程建星,郑仲杰,唐文豪,赵连明,张海涛,姜辉,林浩成. 阴茎海绵体注射试验对阴茎血管功能影响的回顾性研究[J]. 北京大学学报(医学版), 2024, 56(4): 680-686.
[5] 庞博,郭桐君,陈曦,郭华棋,石嘉章,陈娟,王欣梅,李耀妍,单安琪,余恒意,黄婧,汤乃军,王艳,郭新彪,李国星,吴少伟. 天津与上海35岁以上人群氮氧化物个体暴露水平及其影响因素[J]. 北京大学学报(医学版), 2024, 56(4): 700-707.
[6] 李晋娜,许丽娜,李敏,宋怡,张静,贾龙斌. 急性脑梗死患者血清BDNF、IL-18、hs-CRP水平与血管性认知障碍的相关性[J]. 北京大学学报(医学版), 2024, 56(4): 708-714.
[7] 和静,房中则,杨颖,刘静,马文瑶,霍勇,高炜,武阳丰,谢高强. 血浆中脂质代谢分子与颈动脉粥样硬化斑块、传统心血管危险因素及膳食因素的关系[J]. 北京大学学报(医学版), 2024, 56(4): 722-728.
[8] 蔡珊,张依航,陈子玥,刘云飞,党佳佳,师嫡,李佳欣,黄天彧,马军,宋逸. 北京市中小学生身体活动时间现状及影响因素的路径[J]. 北京大学学报(医学版), 2024, 56(3): 403-410.
[9] 张祖洪,陈天娇,马军. 中小学生青春发动时相与心血管代谢危险因素的相关性[J]. 北京大学学报(医学版), 2024, 56(3): 418-423.
[10] 张浩宇,石逸雯,潘薇,刘爱萍,孙昕霙,李曼,张旭熙. 基于不同失能水平的老年人照料需求的影响因素[J]. 北京大学学报(医学版), 2024, 56(3): 431-440.
[11] 靖婷,江华,李婷,申倩倩,叶兰,曾银丹,梁文欣,冯罡,司徒文佑,张玉梅. 中国西部5城市中老年人血清25羟基维生素D与握力的相关性[J]. 北京大学学报(医学版), 2024, 56(3): 448-455.
[12] 汤华萌,袁典琪,王明星,杨晗冰,郭超. 数字融入和健康生活方式对社会经济状况与老年人抑郁关系的序列中介作用[J]. 北京大学学报(医学版), 2024, 56(2): 230-238.
[13] 朱金荣,赵亚娜,黄巍,赵微微,王悦,王松,苏春燕. 感染新型冠状病毒的血液透析患者的临床特征[J]. 北京大学学报(医学版), 2024, 56(2): 267-272.
[14] 赖展鸿,李嘉辰,贠泽霖,张永刚,张昊,邢晓燕,邵苗,金月波,王乃迪,李依敏,李玉慧,栗占国. 特发性炎性肌病完全临床应答相关因素的单中心真实世界研究[J]. 北京大学学报(医学版), 2024, 56(2): 284-292.
[15] 司筱芊,赵秀娟,朱凤雪,王天兵. 创伤出血性休克后急性呼吸窘迫综合征的危险因素[J]. 北京大学学报(医学版), 2024, 56(2): 307-312.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!