口腔种植中血浆基质的临床转化现状与前沿探索

doi:10.19723/j.issn.1671-167X.2025.05.004

摘要/Abstract

摘要： 随着口腔种植学的快速发展，种植体的长期稳定性与美学效果日益受到重视，而充足、健康的软硬组织被认为是其关键保障因素之一。在众多组织再生策略中，血浆基质作为一种源自患者自体血液的生物衍生材料，因其富含多种生长因子、活细胞和纤维蛋白，具有良好的生物相容性、可控的降解性能及简便的制备流程，近年来在口腔种植相关的软硬组织修复中展现出独特而显著的临床价值，应用范围持续扩大。本文在系统梳理相关文献和现有研究证据的基础上，全面综述了血浆基质在口腔种植领域的基础研究与临床应用进展，重点探讨了其材料学分类、分子作用机制、促进组织再生的生物学效应及其在不同临床适应证中的应用策略。同时，本文还对当前研究中存在的技术瓶颈与争议问题进行了深入分析，并提出了未来可能的研究方向与技术发展趋势，旨在为临床实践提供循证支持，为后续科学研究提供理论依据与方法参考。

关键词: 血浆基质, 牙种植体, 骨增量, 软组织再生, 复合生物材料

Abstract: With the rapid development of implant dentistry, increasing attention has been paid to the long-term stability and aesthetic outcomes of dental implants, among which sufficient volume and quality of soft and hard tissues are considered crucial contributing factors for successful treatment outcomes. Among the various available tissue regeneration strategies, plasmatrix, an autologous biomaterial derived from the patient ' s own peripheral blood, has demonstrated unique and significant clinical value in the regeneration and augmentation of both soft and hard tissues associated with dental implant therapy in recent years. This notable potential is primarily attributed to its rich content of multiple growth factors, viable cells, and a supportive fibrin scaffold, along with its excellent biocompatibility, tunable biodegradation profile, and a relatively simple and rapid preparation process that does not require complex laboratory equipment. As a result, its clinical applications have been continuously expanding across a wide range of indications. Based on a comprehensive review of the existing literature and current research evidence, this article provides an in-depth summary of the advancements in both basic science and clinical applications of plasmatrix in the context of implant dentistry. Particular attention is given to its classification from a materials science perspective, underlying molecular mechanisms, biological effects in promoting tissue regeneration, and its implementation under different clinical scenarios. Furthermore, the article discusses unresolved technical challenges and existing controversies, and outlines potential future directions for research and technological innovation, aiming to provide robust evidence-based guidance for clinical practice as well as a theoretical and methodological reference for future scientific investigations.

Key words: Plasmatrix, Dental implants, Bone augmentation, Soft tissue regeneration, Biocomposite materials

中图分类号:

R783.6

王宇蓝, 曾浩, 张玉峰. 口腔种植中血浆基质的临床转化现状与前沿探索[J]. 北京大学学报（医学版）, 2025, 57(5): 836-840.

Yulan WANG, Hao ZENG, Yufeng ZHANG. Current situation and exploration of clinical transformation of plasmatrix in oral implantology[J]. Journal of Peking University (Health Sciences), 2025, 57(5): 836-840.

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