Email Alert | RSS

Journal of Peking University (Health Sciences) ›› 2020, Vol. 52 ›› Issue (4): 750-754. doi: 10.19723/j.issn.1671-167X.2020.04.029

Previous Articles     Next Articles

Effect of initial periodontal therapy on blood parameters related to erythrocyte and platelet in patients with type 2 diabetes mellitus and chronic periodontitis

Hong-yu GAO1,2,Jing-ling XU1,3*,Huan-xin MENG1,△(),Lu HE1,Jian-xia HOU1   

  1. 1. Department of Periodontology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China
    2. Department of Periodontology, School and Hospital of Stomatology, Tianjin Medical University, Tianjin 300070, China
    3. Department of Stomatology, Peking University Third Hospital, Beijing 100191, China
  • Received:2020-02-21 Online:2020-08-18 Published:2020-08-06
  • Contact: Huan-xin MENG E-mail:kqhxmeng@bjmu.edu.cn
  • Supported by:
    Science & Technology Development Fund of Tianjin Education Commission for Higher Education(2016YD16)

RICH HTML

   

PDF (PC)

Abstract:

Objective: To compare the blood parameters related to erythrocyte and platelet between baseline and 3 months after initial periodontal therapy in patients with both type 2 diabetes mellitus and chronic periodontitis (DM-P). Methods: According to the International Symposium on Classification of Periodontal Diseases and Conditions in 1999 and the diagnostic criteria of type 2 diabetes mellitus proposed by the World Health Organization in 1999, 35 patients with DM-P were recruited. All the participants received initial periodontal therapy, including oral hygiene instruction, scaling, and root planning provided by one senior periodontist. Original diet, exercise, and medication for blood glucose control were unchanged for all the participants. At baseline and 3 months after initial periodontal therapy, the clinical periodontal parameters, including probing depth (PD), bleeding index (BI) and clinical attachment loss (CAL); erythrocyte-related indexes, including red blood cell (RBC) count, hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), RBC volume distribution width (RDW); platelet-related indexes, including platelet (PLT) count, mean platelet volume (MPV), platelet distribution width (PDW), plateletocrit (PCT) were measured and compared. Results: Compared with baseline, the periodontal parameters, including PD [(3.370±0.601) mm vs. (2.729±0.431) mm], BI [2.160 (1.550~3.410) vs. 1.420 (1.000~2.970)] and CAL [(3.307±1.577) mm vs. (2.990±1.587) mm], were significantly reduced (P<0.001) three months after the initial periodontal therapy; the erythrocyte-related indexes, including RBC count [(4.727±0.392)×1012/L vs. (4.825±0.394)×1012/L, P=0.010], HGB [(145.886±11.792) g/L vs. (149.200±12.979) g/L, P=0.007] and HCT [43.40% (37.50%~48.50%) vs. 43.80% (38.50%~53.20%), P=0.003], were significantly increased three months after the initial periodontal therapy; PLT count [(216.714±61.900)×109/L vs. (205.886±62.051)×109/L, P=0.016] was significantly reduced 3 months after the initial periodontal therapy. Conclusion: The initial periodontal therapy can significantly improve blood parameters related to RBC and PLT, which might decrease the risk of vascular complications in DM-P patients.

Key words: Diabetes mellitus, type 2, Periodontitis, Erythrocytes, Blood platelets, Initial periodontal therapy

CLC Number: 

  • R781.42

Table 1

Effects of initial periodontal therapy on clinical parameters in DM-P patients"

Periodontal clinical parameters Baseline 3 months after therapy P
PD/mm,$\bar{x}±s$ 3.370±0.601 2.729±0.431 <0.001
BI, median (range) 2.160 (1.550-3.410) 1.420 (1.000-2.970) <0.001
CAL/mm,$\bar{x}±s$ 3.307±1.577 2.990±1.587 <0.001

Table 2

Effects of initial periodontal therapy on erythrocyte-related index in DM-P patients"

Erythrocyte-related index Baseline 3 months after therapy P
RBC/(×1012/L),$\bar{x}±s$ 4.727±0.392 4.825±0.394 0.010
HGB/(g/L), $\bar{x}±s$ 145.886±11.792 149.200±12.979 0.007
HCT/%, median (range) 43.40 (37.50-48.50) 43.80 (38.50-53.20) 0.003
MCV/fL, $\bar{x}±s$ 91.574±3.374 92.134±3.299 0.133
MCH/pg, median (range) 30.90 (29.00-34.30) 30.80 (28.10-33.30) 0.644
MCHC/(g/L), $\bar{x}±s$ 337.543±6.997 335.771±9.696 0.352
RDW_CV/%, median (range) 12.80 (11.90-14.40) 12.80 (11.80-13.90) 0.720

Table 3

Effects of initial periodontal therapy on platelet-related index in DM-P patients"

Platelet-related index Baseline 3 months after therapy P
PLT/(×109/L), x?±s 216.714±61.900 205.886±62.051 0.016
MPV/fL, x?±s 10.757±1.488 11.017±1.356 0.202
PDW/fL, median (range) 13.40 (10.40-18.30) 13.40 (9.50-19.90) 0.521
PCT/%, x?±s 23.343±6.049 22.429±6.568 0.296
[1] Festa A, D’Agostino R Jr, Howard G, et al. Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS)[J]. Circulation, 2000,102(1):42-47.
[2] 范志佳, 徐黎明, 王力, 等. 糖尿病患者血小板高活性状态研究进展[J]. 检验医学, 2018,33(12):1144-1147.
[3] 孙明玥, 李旭妍, 杨丽丽, 等. 糖尿病微血管病变与红细胞改变的相关性[J]. 中国糖尿病杂志, 2019,27(9):718-720.
[4] Wang Z, Song Z, Bai J, et al. Red blood cell count as an indicator of microvascular complications in Chinese patients with type 2 diabetes mellitus[J]. Vasc Health Risk Manag, 2013(9):237-242.
[5] 江兰, 金秀平, 魏剑芬, 等. 2 型糖尿病患者RBC数减少与微血管病变发生的关系[J]. 山西医科大学学报, 2018,49(1):40-43.
[6] Demirtunc R, Duman D, Basar M, et al. The relationship between glycemic control and platelet activity in type 2 diabetes mellitus[J]. J Diabetes Complications, 2009,23(2):89-94.
[7] 马晓天, 顾建华, 王丽, 等. 血小板计数与代谢综合征关联性前瞻性队列研究[J]. 山东大学学报(医学版), 2018,56(12):92-97.
[8] Papapanou PN. Periodontal diseases: epidemiology[J]. Ann Periodontol, 1996,1(1):1-36.
[9] Kim J, Amar S. Periodontal disease and systemic conditions: A bidirectional relationship[J]. Odontology, 2006,94(1):10-21.
doi: 10.1007/s10266-006-0060-6 pmid: 16998613
[10] Katagiri1 S, Nagasawa T, Kobayashi1 H, et al. Improvement of glycemic control after periodontal treatment by resolving gingival inflammation in type 2 diabetic patients with periodontal disease[J]. J Diabetes Invest, 2012,3(4):402-409.
[11] 徐菁玲, 孟焕新, 李峥, 等. 牙周基础治疗对2型糖尿病伴慢性牙周炎患者血糖代谢指标及血清生化指标的影响[J]. 北京大学学报(医学版), 2013,45(1):27-32.
[12] Gokhale SR, Sumanth S, Padhye AM. Evaluation of blood para-meters in patients with chronic periodontitis for signs of anemia[J]. J Periodontol, 2010,81(8):1202-1206.
pmid: 20476889
[13] Anand PS, Sagar DK, Ashok S, et al. Association of aggressive periodontitis with reduced erythrocytes counts and reduced hemoglobin levels[J]. J Periodont Res, 2014,49(6):719-728.
[14] Prakash S, Dhingra K, Priya S. Similar hematological and biochemical parameters among periodontitis and control group subjects[J]. Eur J Dent, 2012,6(3):287-294.
pmid: 22904657
[15] Franca LFC, da Silva FRP, di Lenardo D, et al. Comparative analysis of blood parameters of the erythrocyte lineage between patients with chronic periodontitis and healthy patients: Results obtained from a meta-analysis[J]. Arch Oral Biol, 2019(97):144-149.
[16] Musalaiah SV, Anupama M, Nagasree M, et al. Evaluation of nonsurgical periodontal therapy in chronic periodontitis patients with anemia by estimating hematological parameters and high-sensitivity C-reactive protein levels[J]. 2014,6(Suppl 1):S64-S69.
[17] Malhotra R, Kapoor A, Grover V, et al. Effect of scaling and root planing on erythrocyte count, hemoglobin and hematocrit in patients with chronic periodontal disease[J]. J Dent Hyg, 2012,86(3):195-203.
pmid: 22947842
[18] Romandini M, Lofori A, Romandini P, et al. Periodontitis and platelet count: A new potential link with cardiovascular and other systemic inflammatory diseases[J]. J Clin Periodontol, 2018,45(11):1299-1310.
doi: 10.1111/jcpe.13004 pmid: 30133784
[19] AI-Raseed A. Elevation of white blood cells and platelet counts in patients having chronic periodontitis[J]. Saudi Dent J, 2012,24(1):17-21.
pmid: 23960523
[20] Wang X, Meng H, Chen Z, et al. Mean platelet volume as an inflammatory marker in patients with severe periodontitis[J]. Platelet, 2015,26(1):67-71.
[21] Kumar BP, Khaitan T, Ramaswamy P, et al. Association of chronic periodontitis with white blood cell and platelet count: A case control study[J]. J Clin Exp Dent, 2014,6(3):e214-e217.
doi: 10.4317/jced.51292 pmid: 25136419
[22] Zuberi BF, Akhtar N, Afsar S. Comparison of mean platelet vo-lume in patients with diabetes mellitus, impaired fasting glucose and nondiabetic subjects[J]. Singapore Med J, 2008,49(2):114-116.
pmid: 18301837
[23] Banthia R, Jain P, Banthia P, et al. Effect of phase I periodontal therapy on pro-coagulant state in chronic periodontitis patients: A clinical and haematological study[J]. J Ir Dent Assoc, 2013,59(4):183-188.
pmid: 24156210
[24] Pan L, Ye Y, Wo M, et al. Clinical significance of hemostatic parameters in the prediction for type 2 diabetes mellitus and diabetic nephropathy [J]. Dis Markers, (2018-02-04)[2019-11-18]. doi: 10.1155/2018/5214376.
[25] Ferreira LL, Gomes JE Filho, Sumida DH, et al. Diabetic rats present high mean platelet count in the presence of oral infections[J]. Braz Dent J, 2017,28(5):548-551.
pmid: 29215677
[1] Peiheng ZHANG, Ying GAO, Honghua WU, Jian ZHANG, Junqing ZHANG. Fulminant type 1 diabetes mellitus with acute pancreatitis: A case report and literature review [J]. Journal of Peking University (Health Sciences), 2024, 56(5): 923-927.
[2] Yuru HU,Juan LIU,Wenjing LI,Yibing ZHAO,Qiqiang LI,Ruifang LU,Huanxin MENG. Relationship between short-chain fatty acids in the gingival crevicular fluid and periodontitis of stage Ⅲ or Ⅳ [J]. Journal of Peking University (Health Sciences), 2024, 56(2): 332-337.
[3] Yujia MA,Ranli LU,Zechen ZHOU,Xiaoyi LI,Zeyu YAN,Yiqun WU,Dafang CHEN. Association between insomnia and type 2 diabetes: A two-sample Mendelian rando-mization study [J]. Journal of Peking University (Health Sciences), 2024, 56(1): 174-178.
[4] Han ZHANG,Yixuan QIN,Diyuan WEI,Jie HAN. A preliminary study on compliance of supportive treatment of patients with periodontitis after implant restoration therapy [J]. Journal of Peking University (Health Sciences), 2024, 56(1): 39-44.
[5] Chang SHU,Ye HAN,Yuzhe SUN,Zaimu YANG,Jianxia HOU. Changes of parameters associated with anemia of inflammation in patients with stage Ⅲ periodontitis before and after periodontal initial therapy [J]. Journal of Peking University (Health Sciences), 2024, 56(1): 45-50.
[6] Lei BAO,Xia-xia CAI,Ming-yuan ZHANG,Lei-lei REN. Effect of vitamin D3 on mild cognitive impairment in type 2 diabetic mice and its possible mechanism [J]. Journal of Peking University (Health Sciences), 2023, 55(4): 587-592.
[7] Xi-yan PEI,Wen YANG,Xiang-ying OUYANG,Feng SUN. Comparison of clinical effects between periodontal endoscopy aiding subgingival debridement and flap surgery [J]. Journal of Peking University (Health Sciences), 2023, 55(4): 716-720.
[8] Xiao-yue ZHANG,Yu-xin LIN,Ying JIANG,Lan-chao ZHANG,Mang-yan DONG,Hai-yi CHI,Hao-yu DONG,Li-jun MA,Zhi-jing LI,Chun CHANG. Mediating effect of self-efficacy on self-management ability and self-management behavior in patients with type 2 diabetes mellitus [J]. Journal of Peking University (Health Sciences), 2023, 55(3): 450-455.
[9] Huan YU,Ruo-tong YANG,Si-yue WANG,Jun-hui WU,Meng-ying WANG,Xue-ying QIN,Tao WU,Da-fang CHEN,Yi-qun WU,Yong-hua HU. Metformin use and risk of ischemic stroke in patients with type 2 diabetes: A cohort study [J]. Journal of Peking University (Health Sciences), 2023, 55(3): 456-464.
[10] Jing WEN,Xiang-ying OUYANG,Xi-yan PEI,Shan-yong QIU,Jian-ru LIU,Wen-yi LIU,Cai-fang CAO. Multivariable analysis of tooth loss in subjects with severe periodontitis over 4-year natural progression [J]. Journal of Peking University (Health Sciences), 2023, 55(1): 70-77.
[11] WU Jun-hui,WU Yi-qun,WU Yao,WANG Zi-jing,WU Tao,QIN Xue-ying,WANG Meng-ying,WANG Xiao-wen,WANG Jia-ting,HU Yong-hua. Incidence and risk factors of ischemic stroke in patients with type 2 diabetes among urban workers in Beijing, China [J]. Journal of Peking University (Health Sciences), 2022, 54(2): 249-254.
[12] ZHU Xiao-ling,LI Wen-jing,WANG Xian-e,SONG Wen-li,XU Li,ZHANG Li,FENG Xiang-hui,LU Rui-fang,SHI Dong,MENG Huan-xin. Gene polymorphisms of cytochrome B-245 alpha chain (CYBA) and cholesteryl ester transfer protein (CETP) and susceptibility to generalized aggressive periodontitis [J]. Journal of Peking University (Health Sciences), 2022, 54(1): 18-22.
[13] XU Xin-ran,HUO Peng-cheng,HE Lu,MENG Huan-xin,ZHU Yun-xuan,JIN Dong-si-qi. Comparison of initial periodontal therapy and its correlation with white blood cell level in periodontitis patients with or without diabetes mellitus [J]. Journal of Peking University (Health Sciences), 2022, 54(1): 48-53.
[14] GAO Hong-yu,MENG Huan-xin,HOU Jian-xia,HUANG Bao-xin,LI Wei. Expression and distribution of calprotectin in healthy and inflamed periodontal tissues [J]. Journal of Peking University (Health Sciences), 2021, 53(4): 744-749.
[15] GUO Hong-ping,ZHAO Ai,XUE Yong,MA Liang-kun,ZHANG Yu-mei,WANG Pei-yu. Relationship between nutrients intake during pregnancy and the glycemic control effect in pregnant women with gestational diabetes mellitus [J]. Journal of Peking University (Health Sciences), 2021, 53(3): 467-472.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright © Journal of Peking University (Health Sciences), All Rights Reserved.
Powered by Beijing Magtech Co. Ltd