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Journal of Peking University (Health Sciences) ›› 2020, Vol. 52 ›› Issue (4): 750-754. doi: 10.19723/j.issn.1671-167X.2020.04.029

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Effect of initial periodontal therapy on blood parameters related to erythrocyte and platelet in patients with type 2 diabetes mellitus and chronic periodontitis

Hong-yu GAO1,2,Jing-ling XU1,3*,Huan-xin MENG1,△(),Lu HE1,Jian-xia HOU1   

  1. 1. Department of Periodontology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China
    2. Department of Periodontology, School and Hospital of Stomatology, Tianjin Medical University, Tianjin 300070, China
    3. Department of Stomatology, Peking University Third Hospital, Beijing 100191, China
  • Received:2020-02-21 Online:2020-08-18 Published:2020-08-06
  • Contact: Huan-xin MENG E-mail:kqhxmeng@bjmu.edu.cn
  • Supported by:
    Science & Technology Development Fund of Tianjin Education Commission for Higher Education(2016YD16)

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Abstract:

Objective: To compare the blood parameters related to erythrocyte and platelet between baseline and 3 months after initial periodontal therapy in patients with both type 2 diabetes mellitus and chronic periodontitis (DM-P). Methods: According to the International Symposium on Classification of Periodontal Diseases and Conditions in 1999 and the diagnostic criteria of type 2 diabetes mellitus proposed by the World Health Organization in 1999, 35 patients with DM-P were recruited. All the participants received initial periodontal therapy, including oral hygiene instruction, scaling, and root planning provided by one senior periodontist. Original diet, exercise, and medication for blood glucose control were unchanged for all the participants. At baseline and 3 months after initial periodontal therapy, the clinical periodontal parameters, including probing depth (PD), bleeding index (BI) and clinical attachment loss (CAL); erythrocyte-related indexes, including red blood cell (RBC) count, hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), RBC volume distribution width (RDW); platelet-related indexes, including platelet (PLT) count, mean platelet volume (MPV), platelet distribution width (PDW), plateletocrit (PCT) were measured and compared. Results: Compared with baseline, the periodontal parameters, including PD [(3.370±0.601) mm vs. (2.729±0.431) mm], BI [2.160 (1.550~3.410) vs. 1.420 (1.000~2.970)] and CAL [(3.307±1.577) mm vs. (2.990±1.587) mm], were significantly reduced (P<0.001) three months after the initial periodontal therapy; the erythrocyte-related indexes, including RBC count [(4.727±0.392)×1012/L vs. (4.825±0.394)×1012/L, P=0.010], HGB [(145.886±11.792) g/L vs. (149.200±12.979) g/L, P=0.007] and HCT [43.40% (37.50%~48.50%) vs. 43.80% (38.50%~53.20%), P=0.003], were significantly increased three months after the initial periodontal therapy; PLT count [(216.714±61.900)×109/L vs. (205.886±62.051)×109/L, P=0.016] was significantly reduced 3 months after the initial periodontal therapy. Conclusion: The initial periodontal therapy can significantly improve blood parameters related to RBC and PLT, which might decrease the risk of vascular complications in DM-P patients.

Key words: Diabetes mellitus, type 2, Periodontitis, Erythrocytes, Blood platelets, Initial periodontal therapy

CLC Number: 

  • R781.42

Table 1

Effects of initial periodontal therapy on clinical parameters in DM-P patients"

Periodontal clinical parameters Baseline 3 months after therapy P
PD/mm,$\bar{x}±s$ 3.370±0.601 2.729±0.431 <0.001
BI, median (range) 2.160 (1.550-3.410) 1.420 (1.000-2.970) <0.001
CAL/mm,$\bar{x}±s$ 3.307±1.577 2.990±1.587 <0.001

Table 2

Effects of initial periodontal therapy on erythrocyte-related index in DM-P patients"

Erythrocyte-related index Baseline 3 months after therapy P
RBC/(×1012/L),$\bar{x}±s$ 4.727±0.392 4.825±0.394 0.010
HGB/(g/L), $\bar{x}±s$ 145.886±11.792 149.200±12.979 0.007
HCT/%, median (range) 43.40 (37.50-48.50) 43.80 (38.50-53.20) 0.003
MCV/fL, $\bar{x}±s$ 91.574±3.374 92.134±3.299 0.133
MCH/pg, median (range) 30.90 (29.00-34.30) 30.80 (28.10-33.30) 0.644
MCHC/(g/L), $\bar{x}±s$ 337.543±6.997 335.771±9.696 0.352
RDW_CV/%, median (range) 12.80 (11.90-14.40) 12.80 (11.80-13.90) 0.720

Table 3

Effects of initial periodontal therapy on platelet-related index in DM-P patients"

Platelet-related index Baseline 3 months after therapy P
PLT/(×109/L), x?±s 216.714±61.900 205.886±62.051 0.016
MPV/fL, x?±s 10.757±1.488 11.017±1.356 0.202
PDW/fL, median (range) 13.40 (10.40-18.30) 13.40 (9.50-19.90) 0.521
PCT/%, x?±s 23.343±6.049 22.429±6.568 0.296
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