关键词: 肾切除术, 癌, 肾细胞, 肿瘤复发, 局部, 预后

Abstract: Objective：To characterize the long-term outcome of surgical extirpation for local recurrence after radical nephrectomy of renal cell carcinoma (RCC) and identify prognostic factors for locally recurrent RCC. Methods: Peking University First Hospital urologic database was queried for all patients with isolated local recurrence following radical nephrectomy for localized RCC. According to previous literature, local recurrence included relapse in the renal fossa, ipsilateral adrenal gland and ipsilateral retroperitoneal lymph nodes. The median follow up was 62 months. The cancer specific survival and relapse patterns were estimated using the Kaplan-Meier method. Results: In our institutional database,1 045 patients were treated with nephrectomy for localized RCC from January 1994 to December 2011.With a postoperative follow-up of (62.7±36.2) months, 15 patients (1.44%) experienced local recurrence, 9 of which were managed by surgical resection, and the rest 6 did not receive operation. The patients who received surgical resection had a 1-year cancer specific survival rate of 87%, compared with 60% of the patients without receiving surgical treatment. The 4-year cancer specific survival rate was 72% vs. 30%.The survival time was(51.8±7.4) months vs. (28.4±9.2) months. The recurrence interval was (39.4±29.5)months vs. (29.3±23.9) months. Conclusion: Surgical resection for local recurrence of RCC in selected patients is a feasible management and may prolong the survival time.

Key words: Nephrectomy, Carcinoma, renal cell, Neoplasm recurrence, local, Prognosis