北京大学学报(医学版) ›› 2017, Vol. 49 ›› Issue (5): 835-839. doi: 10.3969/j.issn.1671-167X.2017.05.016

• 论著 • 上一篇    下一篇

强直性脊柱炎的脊柱手术原因分析

刘蕊, 孙琳, 李常虹, 翟佳羽, 刘湘源   

  1. 北京大学第三医院风湿免疫科, 北京 100191
  • 收稿日期:2016-03-16 出版日期:2017-10-18 发布日期:2017-10-18

Cause analysis of spinal surgery in ankylosing spondylitis

LIU Rui, SUN Lin, LI Chang-hong, ZHAI Jia-yu, LIU Xiang-yuan   

  1. Department of Rheumatology, Peking University Third Hospital, Beijing 100191, China
  • Received:2016-03-16 Online:2017-10-18 Published:2017-10-18

摘要: 目的 了解强直性脊柱炎(ankylosing spondylitis,AS)常见的脊柱手术原因,以便风湿科医师能够更好地为患者制定合理、有效的治疗方案,并普及患者教育。方法 回顾性收集北京大学第三医院自2007年1月至2013年7月在骨科住院并接受脊柱手术的79例AS患者的住院资料,其中男72例,女7例,根据患者手术原因进行总结分析。结果 手术部位以颈椎居多,为59例(74.7%),其他依次为胸腰椎、胸椎、颈胸椎及腰椎。常见的AS脊柱手术原因为骨折、脱位等不稳定因素(53.2%),其中骨折患者27例,多数为创伤所致,其次为脊髓或神经根压迫(34.1%),正畸(12.7%)并不是主要的手术原因。颈椎手术以颈椎病(25例)最多见,其次为颈椎骨折(22例),以颈7椎体骨折最多(8例),因颈椎脱位而手术的病例居第3位(10例)。颈椎手术中寰枢椎病变较常见(13例),主要病因为脱位、半脱位或不稳定,其次为骨折,寰枢椎手术患者的年龄及病程小于其他部位的颈椎手术患者。胸腰椎手术以胸腰椎后凸正畸手术最常见(10例),其次是骨折(6例),多发生于胸11~12椎体。根据入院时间将接受脊柱手术的AS患者按年份进行统计,2007—2008年最多为34例,2009—2010年为26例,2011—2013年7月仅19例,接受手术人数呈逐年递减趋势。结论 AS脊柱手术节段以颈椎为主,寰枢椎病变并不少见。AS脊柱手术的原因以骨折等脊柱不稳定病变和压迫症状为主,创伤因素也占相当比例。虽然接受脊柱手术的AS患者正逐年减少,但风湿科医师仍需加强对AS患者的早期诊疗及规范患者教育。

关键词: 强直性脊柱炎, 脊柱, 外科手术

Abstract: Objective: To investigate the common cause of spinal surgery in ankylosing spondylitis (AS) and to develop reasonable and effective treatment programs for rhematologists. Methods: In this study, 79 AS patients (72 males, 7 females) hospitalized in the Department of Orthopedic and received spinal surgery in Peking University Third Hospital from January 2007 to July 2013 were investigated retrospectively. The causes of the spinal surgery were analyzed. Results: The majority of the surgery were of cervical vertebra surgery for 59 cases (74.7%), followed by the thoracolumbar vertebra, thoracic vertebra, cervicothoracic vertebra, and lumbar vertebra. The common causes of AS spinal surgery were instability (53.2%) including fracture and dislocation caused by trauma mostly, followed by compression symptoms (34.1%). However, the orthopaedic surgery (12.7%) was not the predominant surgery causes. The most common cause of cervical surgery was cervical spondylosis (25 cases), followed by cervical fracture (22 cases) and cervical dislocation (10 cases). For cervical fracture, the most common site was C7 (8 cases). Atlanto-axial vertebral lesions (13 cases) induced by dislocation, subluxation, instability and fracture were common in cervical vertebra surgery. The age and disease duration of atlantoaxial surgical patient’s were less than other parts of the cervical surgery. Thoracolumbar vertebra surgery included thoracolumbar kyphosis orthopaedic surgery (10 cases), and fractures (6 cases), which mainly occurred in T11-12 vertebrae. According to the time of admission for surgery, the cases of AS that received spinal surgery were 34 from 2007 to 2008. The number of the cases that accepted the surgery decreased gradually year by year. Conclusion: The majority surgery section was cervical vertebra, and atlanto-axial vertebral lesions were not rare as we thought. The main etiology of spinal surgery for AS patients was instability, e.g. fracture and compression symptoms. Of course, trauma accounted for the relative percentage of this phetonomenon. Although, the annual number of patients who receives spinal surgery is decreasing, to go to make early diagnosis and treatment, and to standardize patient education for AS patients are still important.

Key words: Ankylosing spondylitis, Spine, Surgical procedures

中图分类号: 

  • R593.23
[1] van der Linden S, van der Heijde D. Ankylosing spondylitis. Clinical features[J]. Rheum Dis Clin North Am, 1998, 24(4): 663-676.
[2] van der Linden SM, Valkenburg HA, Cats A. Evaluation of diagnositic criteria for ankylosing spondylitis. A proposal formodification of the New York criteria [J]. Arthritis Rheum, 1984, 27(4): 361-368.
[3] 刘欣, 白人骁, 李德达, 等. 强直性脊柱炎合并胸腰椎骨折的临床分析[J]. 中国骨伤, 2009, 22(7): 488-490.
[4] Westerveld LA, Verlaan JJ, Oner FC. Spinal fractures in patients with ankylosing spinal disorders: a systematic review of the literature on treatment, neurological status and complications [J]. Eur Spine J, 2009, 18(2): 145-156.
[5] Sambrook PN, Geusens P. The epidemiology of osteoporosis and fractures in ankylosing spondylistis [J]. Ther Adv Musculoskelet Dis, 2012, 4(4): 287-292.
[6] Altun I, Yuksel KZ. Ankylosing spondylitis: Patterns of spinal injury and treatment outcomes [J]. Asian Spine J, 2016, 10(4): 655-662.
[7] 洪锋, 倪建平. 强直性脊柱炎下颈椎骨折的临床回顾性分析 [J]. 中国骨伤, 2013, 26(6): 508-511.
[8] 郭昭庆, 党耕町, 陈仲强, 等. 强直性脊柱炎脊柱骨折的治疗[J]. 中华外科杂志, 2004, 42(6): 334-339.
[9] 陈建宇, 杨泽宏, 刘庆余, 等. 强直性脊柱炎脊柱骨折的影像学表现[J]. 中国医学影像技术, 2010, 26(8): 1534-1537.
[10] Lukasiewicz AM, Bohl DD, Varthi AG, et al. spinal fracture in patients with ankylosing spondylitis: cohort definition, distribution of injuries, and hospital outcomes [J]. Spine (Phila Pa 1976), 2016, 41(3): 191-196.
[11] Werner BC, Samartzis D, Shen FH. spinal fractures in patients with ankylosing spondylitis: etiology, diagnosis, and management [J]. J Am Acad Orthop Surg, 2016, 24(4): 241-249.
[12] 史晓飞, 傅建斌. 强直性脊柱炎并寰枢椎关节脱位二例[J]. 中华风湿病学杂志, 2001, 5(6): 345.
[13] 段新旺, 王慧, 吴爱瑜. 女性强直性脊柱炎致颈寰枢椎关节固定一例[J]. 中华风湿病杂志, 2013, 17(2): 142-143.
[14] 刘进子. 外伤后以左胸肋痛首发并寰枢椎受累强直性脊柱炎1例[J]. 中国现代医生, 2007, 45(18): 146.
[15] 张金鹏, 徐顺利, 岳强, 等. 枕颈融合术治疗强直性脊柱炎(AS)患者寰枢椎脱位疗效分析 [J]. 中医学报, 2011, 26(159): 921-922.
[16] 常保国, 徐朝建, 宋洁富. 寰枢椎不稳定的手术治疗策略[J]. 中华骨伤, 2008, 21(1): 25-27.
[17] 钱邦平, 邱勇, 王斌, 等. 强直性脊柱炎胸腰椎后凸畸形的手术矫形时机选择[J]. 中华风湿病学杂志, 2007, 11(2): 101-104.
[1] 李君,刘旭红,王工,程程,庄洪卿,杨瑞杰. 手臂位置对射波刀放射治疗脊柱肿瘤患者的剂量学影响[J]. 北京大学学报(医学版), 2022, 54(1): 182-186.
[2] 苏俊琪,宋扬,谢尚. 口腔鳞状细胞癌患者修复重建术后感染的病原学特征及感染风险预测模型的构建[J]. 北京大学学报(医学版), 2022, 54(1): 68-76.
[3] 朱敬先,鲁胜楠,蒋艳芳,姜玲,王健全. 老年肩袖损伤手术患者术前肺功能的影响因素[J]. 北京大学学报(医学版), 2021, 53(5): 902-906.
[4] 林国中, 马长城, 王振宇, 谢京城, 刘彬, 陈晓东. 1~2硬膜外神经鞘瘤的显微微创治疗[J]. 北京大学学报(医学版), 2021, 53(3): 586-589.
[5] 李新飞, 彭意吉, 余霄腾, 熊盛炜, 程嗣达, 丁光璞, 杨昆霖, 唐琦, 米悦, 吴静云, 张鹏, 谢家馨, 郝瀚, 王鹤, 邱建星, 杨建, 李学松, 周利群. 肾部分切除术前CT三维可视化评估标准的初步探究[J]. 北京大学学报(医学版), 2021, 53(3): 613-622.
[6] 周柏林,李危石,孙垂国,齐强,陈仲强,曾岩. 脊柱手术后深部切口感染患者多次清创的危险因素[J]. 北京大学学报(医学版), 2021, 53(2): 286-292.
[7] 杨阳,肖锋,王进,宋波,李西慧,张师杰,何志嵩,张寰,尹玲. 同期手术治疗心脏病和非心脏疾病[J]. 北京大学学报(医学版), 2021, 53(2): 327-331.
[8] 侯国进,周方,田耘,姬洪全,张志山,郭琰,吕扬,杨钟玮,张雅文. 后路短节段跨伤椎椎弓根螺钉固定治疗胸腰段爆裂骨折术后再发后凸的危险因素[J]. 北京大学学报(医学版), 2021, 53(1): 167-174.
[9] 柯岩,张蔷,马云青,李儒军,陶可,桂先革,李克鹏,张洪,林剑浩. 全髋关节置换术治疗脊柱骨骺发育不良患者Tönnis 3级髋关节骨关节炎的早期疗效[J]. 北京大学学报(医学版), 2021, 53(1): 175-182.
[10] 孟昭婷,穆东亮. 肺叶切除术中少尿与术后急性肾损伤的关系[J]. 北京大学学报(医学版), 2021, 53(1): 188-194.
[11] 刘世博,高辉,冯元春,李静,张彤,万利,刘燕鹰,李胜光,罗成华,张学武. 腹膜后纤维化致肾盂积水的临床分析:附17例报道[J]. 北京大学学报(医学版), 2020, 52(6): 1069-1074.
[12] 徐贝宇,漆龙涛,王宇,李淳德,孙浩林,王诗军,于峥嵘,赵耀,刘龙龙. 短期头盆环牵引配合手术治疗重度脊柱畸形的临床疗效[J]. 北京大学学报(医学版), 2020, 52(5): 875-880.
[13] 王田,洪欣,王晓峰. 等离子针状电极在经尿道近输尿管口膀胱肿瘤切除术中的临床应用(附16例报道)[J]. 北京大学学报(医学版), 2020, 52(4): 632-636.
[14] 熊盛炜,王杰,朱伟杰,程嗣达,张雷,李学松,周利群. 二次肾盂成形术在复发性肾盂输尿管连接部梗阻中的研究进展[J]. 北京大学学报(医学版), 2020, 52(4): 794-798.
[15] 程嗣达,李新飞,熊盛炜,樊书菠,王杰,朱伟杰,李子奡,丁光璞,俞婷,李万强,孙永明,杨昆霖,张雷,郝瀚,李学松,周利群. 机器人辅助腹腔镜上尿路修复手术:单一术者108例经验总结[J]. 北京大学学报(医学版), 2020, 52(4): 771-779.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] 万有, , 韩济生, John E. Pintar. 孤啡肽基因敲除小鼠电针镇痛作用增强[J]. 北京大学学报(医学版), 2009, 41(3): 376 -379 .
[2] 张燕, 韩志慧, 钟延丰, 王盛兰, 李玲玲, 郑丹枫. 骨骼肌活组织检查病理诊断技术的改进及应用[J]. 北京大学学报(医学版), 2009, 41(4): 459 -462 .
[3] 赵奇, 薛世华, 刘志勇, 吴凌云. 同向施压测定自酸蚀与全酸蚀粘接系统粘接强度[J]. 北京大学学报(医学版), 2010, 42(1): 82 -84 .
[4] 林红, 王玉凤, 吴野平. 学校生活技能教育对小学三年级学生行为问题影响的对照研究[J]. 北京大学学报(医学版), 2007, 39(3): 319 -322 .
[5] 丰雷, 程嘉, 王玉凤. 注意缺陷多动障碍儿童的运动协调功能[J]. 北京大学学报(医学版), 2007, 39(3): 333 -336 .
[6] 李岳玲, 钱秋瑾, 王玉凤. 儿童注意缺陷多动障碍成人期预后及其预测因素[J]. 北京大学学报(医学版), 2007, 39(3): 337 -340 .
[7] 张宏文, 丁洁, 王芳, 杨惠霞. 一例X连锁Alport综合征女性妊娠期随访[J]. 北京大学学报(医学版), 2007, 39(4): 351 -354 .
[8] 常杏芝, 卢红梅, 张月华, 秦炯. 以高血压与红斑肢痛为主要表现的汞中毒一例[J]. 北京大学学报(医学版), 2007, 39(4): 377 -380 .
[9] 李西慧, 肖锋, 李岩, 杜迎利, 宋乃庆, 张明礼. 川崎病合并心肌梗死临床治疗一例[J]. 北京大学学报(医学版), 2007, 39(4): 381 -384 .
[10] 郭艳红, 李黔, 于海奕, 高炜. 增殖抑制基因诱导血管平滑肌细胞凋亡[J]. 北京大学学报(医学版), 2007, 39(4): 394 -398 .