北京大学学报(医学版) ›› 2018, Vol. 50 ›› Issue (6): 952-955. doi: 10.19723/j.issn.1671-167X.2018.06.002

• 专家笔谈 • 上一篇    下一篇

自身抗体在肿瘤及感染性疾病发生、发展中的作用

王永福(),刘媛   

  1. 内蒙古科技大学包头医学院第一附属医院风湿免疫科, 内蒙古自治区包头 014010
  • 收稿日期:2018-10-18 出版日期:2018-12-18 发布日期:2018-12-17
  • 通讯作者: 王永福 E-mail:18047211500@163.com

  • Received:2018-10-18 Online:2018-12-18 Published:2018-12-17

RICH HTML

  

关键词: 结缔组织病, 自身抗体, 肿瘤, 感染性疾病

中图分类号: 

  • R593.2

表1

ANAs与肿瘤类型的相关性"

CTD ANAs Tumor
SLE Anti-Sm antibody Lung cancer, pancreatic cancer, colon cancer, cervical cancer
Anti-SS-A antibody Lymphoma, myeloma,teratoma
Anti-SS-B antibody NHL, squamous cell carcinoma
SSc Scl-70 Lung cancer, ovarian cancer, breast cancer
pSS Anti-SS-A antibody NHL, squamous cell carcinoma
Anti-SS-B antibody NHL
[1] Burnham TK . Antinuclear antibodies in patients with malignancies[J]. Lancet, 1972,2(7774):436.
doi: 10.1016/S0140-6736(72)91842-9 pmid: 4115262
[2] Vlagea A, Falagan S, Gutierrez-Gutierrez G , et al. Antinuclear antibodies and cancer: A literature review[J]. Crit Rev Oncol Hematol, 2018,127:42-49.
doi: 10.1016/j.critrevonc.2018.05.002
[3] Sahin U, Tureci O, Schmitt H , et al. Human neoplasms elicit multiple specific immune responses in the autologous host[J]. Proc Natl Acad Sci USA, 1995,92(25):11810-11813.
doi: 10.1073/pnas.92.25.11810 pmid: 8524854
[4] Dellen H, Seemayer NH . Autoimmunity in patients with bronchogenic carcinomas: occurrence of antibodies against nuclear antigens, chromosomes and ds-deoxyribonucleic acid[J]. Zentralbl Bakteriol Mikrobiol Hyg B, 1983,177(6):451-468.
pmid: 6322478
[5] Riska H, Fyhrquist F, Selander RK , et al. Systemic lupus erythematosus and DNA antibodies in pleural effusions[J]. Scand J Rheumatol, 1978,7(3):159-160.
doi: 10.3109/03009747809095646 pmid: 310156
[6] Attar SM, Koshak EA . Medical conditions associated with a positive anti-double-stranded deoxyribonucleic acid[J]. Saudi Med J, 2010,31(7):781-787.
doi: 10.5336/medsci.2009-16065 pmid: 20635012
[7] Cavagna L, Prisco E, Montecucco C , et al. Association between anti-dsDNA titre increase and thymoma relapse[J]. Clin Exp Rheumatol, 2011,29(3):599-600.
[8] 邹和建 . 系统性红斑狼疮与自身抗体[J]. 皮肤科学通报, 2018,35(3):258-264.
[9] Katz U, Zandman-Goddard G . Drug-induced lupus: an update[J]. Autoimmun Rev, 2010,10(1):46-50.
doi: 10.1016/j.autrev.2010.07.005 pmid: 20656071
[10] Kamei M, Kato M, Mochizuki K , et al. Serodiagnosis of cancers by ELISA of anti-histone H2B antibody[J]. Biotherapy, 1992,4(1):17-22.
doi: 10.1007/BF02171705 pmid: 1543647
[11] Sakamoto J, Fujiya M, Okamoto K , et al. Immunoprecipitation of nucleosomal DNA is a novel procedure to improve the sensitivity of serum screening for the p16 hypermethylation associated with colon cancer[J]. Cancer Epidemiol, 2010,34(2):194-199.
doi: 10.1016/j.canep.2010.01.004 pmid: 20129840
[12] Fragkioudaki S, Mavragani CP, Moutsopoulos HM . Predicting the risk for lymphoma development in Sjögren syndrome: An easy tool for clinical use[J]. Medicine, 2016,95(25):e3766.
doi: 10.1097/MD.0000000000003766
[13] Quartuccio L, Baldini C, Bartoloni E , et al. Anti-SSA/SSB-negative Sjögren’s syndrome shows a lower prevalence of lymphoproliferative manifestations, and a lower risk of lymphoma evolution[J]. Autoimmun Rev, 2015,14(11):1019-1022.
doi: 10.1016/j.autrev.2015.07.002
[14] Matsuda M , Yamada T. snRNPs from mouse teratocarcinoma cells reacting with polyclonal anti-Sm and anti-m3(2,2,7)G antibodies and bioche-mical characterization of the snRNPs[J]. Nihon Juigaku Zasshi, 1987,49(6):981-987.
doi: 10.1292/jvms1939.49.981 pmid: 2963163
[15] Imran A, Neelam F, Tariq M . Incidence of circulating antinuclear antibodies in cancer patients[J]. Indian J Med Sci, 2003,57(3):113-116.
pmid: 14514262
[16] Zou HY, Gu X, Yu WZ , et al. Detection of serum antinuclear antibodies in lymphoma patients[J]. Genet Mol Res, 2015,14(4):16546-16552.
doi: 10.4238/2015.December.11.1 pmid: 26681000
[17] Fernandez-Madrid F , VandeVord PJ, Yang X, et al. Antinuclear antibodies as potential markers of lung cancer[J]. Clin Cancer Res, 1999,5(6):1393-1400.
doi: 10.1590/S0004-282X1994000300022 pmid: 10389924
[18] Syrigos KN, Charalambopoulos A, Pliarchopoulou K , et al. The prognostic significance of autoantibodies against dsDNA in patients with colorectal adenocarcinoma[J]. Anticancer Res, 2000,20(6B):4351-4353.
doi: 10.1097/00001813-200011000-00012 pmid: 11205270
[19] Mitchell P, Thatcher N, Socinski MA , et al. Tecemotide in unresectable stage III non-small-cell lung cancer in the phase III START study: updated overall survival and biomarker analyses[J]. Ann Oncol, 2015,26(6):1134-1142.
doi: 10.1093/annonc/mdv104 pmid: 25722382
[20] Maire C, Vercambre-Darras S, Devos P , et al. Metastatic melanoma: spontaneous occurrence of auto antibodies is a good prognosis factor in a prospective cohort[J]. J Eur Acad Dermatol Venereol, 2013,27(1):92-96.
doi: 10.1111/j.1468-3083.2011.04364.x pmid: 22145691
[21] Altintas A, Cil T, Pasa S , et al. Clinical significance of elevated antinuclear antibody test in patients with Hodgkin’s and non-Hodgkin’s lymphoma: a single center experience[J]. Minerva Med, 2008,99(1):7-14.
[22] Tan EM . Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology[J]. Adv Immunol, 1989,44:93-151.
doi: 10.1016/S0065-2776(08)60641-0
[23] Ringrose JH, Muijsers AO, Pannekoek Y , et al. Influence of infection of cells with bacteria associated with reactive arthritis on the peptide repertoire presented by HLA-B27[J]. J Med Microbiol, 2001,50(4):385-389.
doi: 10.1086/319288 pmid: 11289525
[24] Clark SE, Weiser JN . Microbial modulation of host immunity with the small molecule phosphorylcholine[J]. Infect Immun, 2013,81(2):392-401.
doi: 10.1128/IAI.01168-12 pmid: 3553803
[25] Flodstrom-Tullberg M . Viral infections: their elusive role in regulating susceptibility to autoimmune disease[J]. Microbes Infect, 2003,5(10):911-921.
doi: 10.1016/S1286-4579(03)00161-8 pmid: 12919859
[26] Monsalve DM, Pacheco Y, Acosta-Ampudia Y , et al. Zika virus and autoimmunity. One-step forward[J]. Autoimmun Rev, 2017,16(12):1237-1245.
doi: 10.1016/j.autrev.2017.10.008 pmid: 29037898
[27] Sene D, Piette JC, Cacoub P . Antiphospholipid antibodies, antiphospholipid syndrome and infections[J]. Autoimmun Rev, 2008,7(4):272-277.
doi: 10.1016/j.autrev.2007.10.001 pmid: 18295729
[28] Tanay A . Chikungunya virus and autoimmunity[J]. Curr Opin Rheumatol, 2017,29(4):389-393.
doi: 10.1097/BOR.0000000000000396
[29] Wan SW, Lin CF, Yeh TM , et al. Autoimmunity in dengue pathogenesis[J]. J Formos Med Assoc, 2013,112(1):3-11.
doi: 10.1016/j.jfma.2012.11.006
[30] Garzelli C, Pacciardi A, Basolo F , et al. Mechanisms other than polyclonal B cell activation possibly involved in Epstein-Barr virus-induced autoimmunity[J]. Clin Exp Immunol, 1989,76(3):412-416.
doi: 10.1002/chir.22478 pmid: 2546702
[31] Kivity S, Agmon-Levin N, Blank M , et al. Infections and autoimmunity: friends or foes?[J]. Trends Immunol, 2009,30(8):409-414.
doi: 10.1016/j.it.2009.05.005 pmid: 19643667
[32] Rubtsova K , Rubtsov AV, van Dyk LF, et al. T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance[J]. Proc Natl Acad Sci USA, 2013,110(34):E3216-3224.
doi: 10.1073/pnas.1312348110 pmid: 23922396
[33] Yee LJ, Kelleher P, Goldin RD , et al. Antinuclear antibodies (ANA) in chronic hepatitis C virus infection: correlates of positivity and clinical relevance[J]. J Viral Hepat, 2004,11(5):459-464.
doi: 10.1111/j.1365-2893.2004.00530.x pmid: 15357653
[34] Hao Y , O’Neill P, Naradikian MS, et al. A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice[J]. Blood, 2011,118(5):1294-1304.
doi: 10.1182/blood-2011-01-330530
[35] Litwin CM, Binder SR . ANA testing in the presence of acute and chronic infections[J]. J Immunoassay Immunochem, 2016,37(5):439-452.
doi: 10.1080/15321819.2016.1174136 pmid: 27050929
[36] Shoenfeld Y, Vilner Y, Coates AR , et al. Monoclonal anti-tuberculosis antibodies react with DNA, and monoclonal anti-DNA autoantibodies react with Mycobacterium tuberculosis[J]. Clin Exp Immunol, 1986,66(2):255-261.
doi: 10.1016/0008-8749(86)90083-3 pmid: 3102132
[37] Faaber P, Capel PJ, Rijke GP , et al. Cross-reactivity of anti-DNA antibodies with proteoglycans[J]. Clin Exp Immunol, 1984,55(3):502-508.
pmid: 6608423
[1] 李志存, 吴天俣, 梁磊, 范宇, 孟一森, 张骞. 穿刺活检单针阳性前列腺癌术后病理升级的危险因素分析及列线图模型构建[J]. 北京大学学报(医学版), 2024, 56(5): 896-901.
[2] 刘家骏, 刘国康, 朱玉虎. 免疫相关性重症肺炎1例[J]. 北京大学学报(医学版), 2024, 56(5): 932-937.
[3] 黄教悌,胡菁,韩博. 治疗相关神经内分泌前列腺癌机制研究与靶向治疗新进展[J]. 北京大学学报(医学版), 2024, 56(4): 557-561.
[4] 田宇轩,阮明健,刘毅,李德润,吴静云,沈棋,范宇,金杰. 双参数MRI改良PI-RADS评分4分和5分病灶的最大径对临床有意义前列腺癌的预测效果[J]. 北京大学学报(医学版), 2024, 56(4): 567-574.
[5] 姚凯烽,阮明健,李德润,田宇轩,陈宇珂,范宇,刘毅. 靶向穿刺联合区域系统穿刺对PI-RADS 4~5分患者的前列腺癌诊断效能[J]. 北京大学学报(医学版), 2024, 56(4): 575-581.
[6] 欧俊永,倪坤明,马潞林,王国良,颜野,杨斌,李庚午,宋昊东,陆敏,叶剑飞,张树栋. 肌层浸润性膀胱癌合并中高危前列腺癌患者的预后因素[J]. 北京大学学报(医学版), 2024, 56(4): 582-588.
[7] 王滨帅,邱敏,张前进,田茂锋,刘磊,王国良,陆敏,田晓军,张树栋. 6例肾尤文肉瘤伴静脉瘤栓的诊治[J]. 北京大学学报(医学版), 2024, 56(4): 636-639.
[8] 虞乐,邓绍晖,张帆,颜野,叶剑飞,张树栋. 具有低度恶性潜能的多房囊性肾肿瘤的临床病理特征及预后[J]. 北京大学学报(医学版), 2024, 56(4): 661-666.
[9] 舒帆,郝一昌,张展奕,邓绍晖,张洪宪,刘磊,王国良,田晓军,赵磊,马潞林,张树栋. 肾部分切除术治疗囊性肾癌的功能学和肿瘤学结果:单中心回顾性研究[J]. 北京大学学报(医学版), 2024, 56(4): 667-672.
[10] 李正芳,罗采南,武丽君,吴雪,孟新艳,陈晓梅,石亚妹,钟岩. 抗氨基甲酰化蛋白抗体在诊断类风湿关节炎中的应用价值[J]. 北京大学学报(医学版), 2024, 56(4): 729-734.
[11] 方杨毅,李强,黄志高,陆敏,洪锴,张树栋. 睾丸鞘膜高分化乳头状间皮肿瘤1例[J]. 北京大学学报(医学版), 2024, 56(4): 741-744.
[12] 柴晓东,孙子文,李海爽,朱靓怡,刘小旦,刘延涛,裴斐,常青. 髓母细胞瘤分子亚型中CD8+T淋巴细胞浸润的临床病理特点[J]. 北京大学学报(医学版), 2024, 56(3): 512-518.
[13] 赖展鸿,李嘉辰,贠泽霖,张永刚,张昊,邢晓燕,邵苗,金月波,王乃迪,李依敏,李玉慧,栗占国. 特发性炎性肌病完全临床应答相关因素的单中心真实世界研究[J]. 北京大学学报(医学版), 2024, 56(2): 284-292.
[14] 林国中,马长城,吴超,司雨,杨军. 微通道技术在颈椎管肿瘤微创切除术中的应用[J]. 北京大学学报(医学版), 2024, 56(2): 318-321.
[15] 俞光岩. 儿童唾液腺疾病[J]. 北京大学学报(医学版), 2024, 56(1): 1-3.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!