Email Alert | RSS

北京大学学报（医学版） ›› 2026, Vol. 58 ›› Issue (1): 1-9. doi: 10.19723/j.issn.1671-167X.2026.01.001

• 工作综述 •    下一篇

唾液腺非肿瘤性疾病诊治研究进展

丛馨1,2, 苏家增1,3, 吴立玲2, 丁冲1,4, 李巍1,3, 俞光岩1,3,*()   

  1. 1. 北京大学口腔医学院·口腔医院唾液腺疾病研究中心, 国家口腔医学中心, 国家口腔疾病临床医学研究中心, 口腔生物材料和数字诊疗装备国家工程研究中心, 口腔数字医学北京市重点实验室, 北京 100081
    2. 北京大学基础医学院生理学与病理生理学系, 北京 100191
    3. 北京大学口腔医学院·口腔医院口腔颌面外科, 北京 100081
    4. 北京大学口腔医学院·口腔医院中心实验室, 北京 100081
  • 收稿日期:2025-10-21 出版日期:2026-02-18 发布日期:2025-12-10
  • 通讯作者: 俞光岩
  • 基金资助:
    国家自然科学基金(82270993); 国家自然科学基金(31972908); 国家自然科学基金(82170977)

Research progress in diagnosis and treatment of non-tumorous salivary gland diseases

Xin CONG1,2, Jiazeng SU1,3, Liling WU2, Chong DING1,4, Wei LI1,3, Guangyan YU1,3,*()   

  1. 1. Salivary Gland Disease Research Center, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China
    2. Department of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Beijing 100191, China
    3. Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China
    4. Central Laboratory, Peking University School and Hospital of Stomatology, Beijing 100081, China
  • Received:2025-10-21 Online:2026-02-18 Published:2025-12-10
  • Contact: Guangyan YU
  • Supported by:
    the National Natural Science Foundation of China(82270993); the National Natural Science Foundation of China(31972908); the National Natural Science Foundation of China(82170977)

RICH HTML

   

PDF (PC)

摘要：

唾液腺疾病是口腔颌面部常见疾病, 主要分为肿瘤性与非肿瘤性两大类。唾液腺非肿瘤性疾病主要包括唾液腺炎症、干燥综合征、肉芽肿性疾病及发育异常等多种类型。此类疾病部分为局部病变, 部分与系统性疾病相关, 常伴随唾液分泌功能受损, 引发口干及继发性病变。北京大学口腔医学院唾液腺疾病研究中心近二十余年来围绕着紧密连接蛋白对唾液腺分泌功能的调控、新型慢性唾液腺炎[免疫球蛋白(immunoglobulin, Ig)G4相关唾液腺炎、131I相关唾液腺炎和嗜酸性唾液腺导管炎]的临床病理特征与防治、牙髓干细胞治疗干燥综合征及唾液腺发育异常等领域开展了系统性深入研究, 为相关疾病的基础研究与临床诊治提供了重要参考。

关键词: 唾液腺, 紧密连接蛋白, 免疫球蛋白G4相关唾液腺炎, 131I相关唾液腺炎, 嗜酸性唾液腺导管炎

Abstract:

Salivary gland diseases are common disorders in the oral and maxillofacial region, mainly classified into two categories: Tumorous and non-tumorous. Non-tumorous salivary gland diseases include various types such as salivary gland inflammation, Sjögren syndrome, granulomatous diseases, and developmental abnormalities. Some of these diseases are local lesions, while others are closely associated with systemic diseases, often accompanied by impaired salivary secretion function, leading to xerostomia and secondary lesions. Over the past more than 20 years, the Salivary Gland Disease Research Center of Peking University School and Hospital of Stomatology has conducted systematic and in-depth studies focusing on the regulation of salivary secretion function by tight junction proteins, the clinicopathological characteristics, prevention and treatment of novel chronic sialadenitis [including immunoglobulin (Ig) G4-related sialadenitis, 131I-induced sialadenitis, and eosinophilic sialodochitis], stem cells from human exfoliated deciduous teeth-based therapy for Sjögren syndrome, and salivary gland developmental abnormalities. These studies provide important references for the basic research, clinical diagnosis and treatment of related diseases.

Key words: Salivary glands, Tight junction proteins, Immunoglobulin G4-related sialadenitis, 131I-induced sialadenitis, Eosinophilic sialodochitis

中图分类号: 

  • R781.7
1
van Itallie CM, Anderson JM. Architecture of tight junctions and principles of molecular composition[J]. Semin Cell Dev Biol, 2014, 36, 157- 165.

doi: 10.1016/j.semcdb.2014.08.011
2
Maria OM, Kim JM, Gerstenhaber JA, et al. Distribution of tight junction proteins in adult human salivary glands[J]. J Histochem Cytochem, 2008, 56(12): 1093- 1098.

doi: 10.1369/jhc.2008.951780
3
Min SN, Cong X, Zhang Y, et al. Tricellulin modulates transport of macromolecules in the salivary gland[J]. J Dent Res, 2020, 99(3): 302- 310.

doi: 10.1177/0022034519896749
4
Zhang XM, Huang Y, Zhang K, et al. Expression patterns of tight junction proteins in porcine major salivary glands: A comparison study with human and murine glands[J]. J Anat, 2018, 233(2): 167- 176.

doi: 10.1111/joa.12833
5
Cong X, Zhang Y, Shi L, et al. Activation of transient receptor potential vanilloid subtype 1 increases expression and permeability of tight junction in normal and hyposecretory submandibular gland[J]. Lab Invest, 2012, 92(5): 753- 768.

doi: 10.1038/labinvest.2012.12
6
Peppi M, Ghabriel MN. Tissue-specific expression of the tight junction proteins claudins and occludin in the rat salivary glands[J]. J Anat, 2004, 205(4): 257- 266.

doi: 10.1111/j.0021-8782.2004.00332.x
7
Hashizume A, Ueno T, Furuse M, et al. Expression patterns of claudin family of tight junction membrane proteins in developing mouse submandibular gland[J]. Dev Dyn, 2004, 231(2): 425- 431.

doi: 10.1002/dvdy.20142
8
Huang Y, Mao QY, Shi XJ, et al. Disruption of tight junctions contributes to hyposalivation of salivary glands in a mouse model of type 2 diabetes[J]. J Anat, 2020, 237(3): 556- 567.

doi: 10.1111/joa.13203
9
Cong X, Zhang Y, He QH, et al. Endothelial tight junctions are opened in cholinergic-evoked salivation in vivo[J]. J Dent Res, 2017, 96(5): 562- 570.

doi: 10.1177/0022034516685048
10
Steward MC, Seo Y, Rawlings JM, et al. Water permeability of acinar cell membranes in the isolated perfused rabbit mandibular salivary gland[J]. J Physiol, 1990, 431, 571- 583.

doi: 10.1113/jphysiol.1990.sp018348
11
Cong X, Zhang Y, Li J, et al. Claudin-4 is required for modulation of paracellular permeability by muscarinic acetylcholine receptor in epithelial cells[J]. J Cell Sci, 2015, 128(12): 2271- 2286.

doi: 10.1242/jcs.165878
12
He L, Yuan SZ, Mao XD, et al. Claudin-10 decrease in the submandibular gland contributes to xerostomia[J]. J Dent Res, 2024, 103(2): 167- 176.

doi: 10.1177/00220345231210547
13
Zhang Y, Xiang B, Li YM, et al. Expression and characteristics of vanilloid receptor 1 in the rabbit submandibular gland[J]. Biochem Biophys Res Commun, 2006, 345(1): 467- 473.

doi: 10.1016/j.bbrc.2006.04.106
14
Cong X, Zhang Y, Yang NY, et al. Occludin is required for TRPV1-modulated paracellular permeability in the submandibular gland[J]. J Cell Sci, 2013, 126((Pt 5): 1109- 1121.
15
Li J, Cong X, Zhang Y, et al. ZO-1 and-2 are required for TRPV1-modulated paracellular permeability[J]. J Dent Res, 2015, 94(12): 1748- 1756.

doi: 10.1177/0022034515609268
16
Bongers EMHF, Shelton LM, Milatz S, et al. A novel hypokalemic-alkalotic salt-losing tubulopathy in patients with CLDN10 mutations[J]. J Am Soc Nephrol, 2017, 28(10): 3118- 3128.

doi: 10.1681/ASN.2016080881
17
Ewert P, Aguilera S, Alliende C, et al. Disruption of tight junction structure in salivary glands from Sjögren's syndrome patients is linked to proinflammatory cytokine exposure[J]. Arthritis Rheum, 2010, 62(5): 1280- 1289.

doi: 10.1002/art.27362
18
Zhang LW, Cong X, Zhang Y, et al. Interleukin-17 impairs salivary tight junction integrity in Sjögren's syndrome[J]. J Dent Res, 2016, 95(7): 784- 792.

doi: 10.1177/0022034516634647
19
Mei M, Xiang RL, Cong X, et al. claudin-3 is required for modulation of paracellular permeability by TNF-α through ERK1/2/slug signaling axis in submandibular gland[J]. Cell Signal, 2015, 27(10): 1915- 1927.

doi: 10.1016/j.cellsig.2015.07.002
20
Min SN, Wu LL, Zhang YY, et al. Disruption of tight junction structure contributes to secretory dysfunction in IgG4-related sialadenitis[J]. J Mol Histol, 2020, 51(1): 33- 46.

doi: 10.1007/s10735-019-09854-8
21
Huang Y, Liu HM, Mao QY, et al. High glucose reduces the paracellular permeability of the submandibular gland epithelium via the miR-22-3p/Sp1/claudin pathway[J]. Cells, 2021, 10(11): 3230.

doi: 10.3390/cells10113230
22
Yang NY, Ding C, Li J, et al. Muscarinic acetylcholine receptor-mediated tight junction opening is involved in epiphora in late phase of submandibular gland transplantation[J]. J Mol Histol, 2017, 48(2): 99- 111.

doi: 10.1007/s10735-016-9709-9
23
Mao QY, Xie S, Wu LL, et al. Alteration of tight junctions during botulinum toxin type A-inhibited salivary secretion[J]. Oral Dis, 2023, 29(5): 2086- 2095.

doi: 10.1111/odi.14223
24
Liu XJ, Li M, Su JZ, et al. Carbachol improves the secretion of transplanted submandibular glands during the latent period after microvascular autologous transplantation for severe keratoconjunctivitis sicca[J]. Int J Oral Maxillofac Surg, 2016, 45(10): 1273- 1279.

doi: 10.1016/j.ijom.2016.03.015
25
Zhang L, Su JZ, Cai ZG, et al. Factors influencing the long-term results of autologous microvascular submandibular gland transplantation for severe dry eye disease[J]. Int J Oral Maxillofac Surg, 2019, 48(1): 40- 47.

doi: 10.1016/j.ijom.2018.07.006
26
俞光岩, 吴立玲, 蔡志刚, 等. 血管化自体下颌下腺移植治疗重症干眼20年研究[J]. 北京大学学报(医学版), 2018, 50(1): 1- 4.
27
Shan XF, Xu H, Cai ZG, et al. Botulinum toxin A inhibits salivary secretion of rabbit submandibular gland[J]. Int J Oral Sci, 2013, 5(4): 217- 223.

doi: 10.1038/ijos.2013.82
28
Krug SM, Amasheh S, Richter JF, et al. Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability[J]. Mol Biol Cell, 2009, 20(16): 3713- 3724.

doi: 10.1091/mbc.e09-01-0080
29
Mao X, Li H, Min S, et al. Loss of tricellular tight junction tricellulin leads to hyposalivation in Sjögren's syndrome[J]. Int J Oral Sci, 2025, 17(1): 22.

doi: 10.1038/s41368-025-00349-9
30
Mao X, Min S, He Q, et al. In vivo vascular permeability detection in mouse submandibular gland[J]. J Vis Exp, 2022(186): e64167.
31
Cong X, Kong W. Endothelial tight junctions and their regulatory signaling pathways in vascular homeostasis and disease[J]. Cell Signal, 2020, 66, 109485.

doi: 10.1016/j.cellsig.2019.109485
32
Cong X, Zhang XM, Zhang Y, et al. Disruption of endothelial barrier function is linked with hyposecretion and lymphocytic infiltration in salivary glands of Sjögren's syndrome[J]. Biochim Biophys Acta Mol Basis Dis, 2018, 1864(10): 3154- 3163.

doi: 10.1016/j.bbadis.2018.07.002
33
Mao XD, Min SN, Zhu MQ, et al. The role of endothelial barrier function in the fibrosis of salivary gland[J]. J Dent Res, 2023, 102(1): 82- 92.

doi: 10.1177/00220345221118508
34
俞光岩, 洪霞, 李巍, 等. IgG4相关唾液腺炎的临床病理特点及诊断[J]. 北京大学学报(医学版), 2019, 51(1): 1- 3.
35
Hong X, Sun ZP, Li W, et al. Comorbid diseases of IgG4-related sialadenitis in the head and neck region[J]. Laryngoscope, 2015, 125(9): 2113- 2118.

doi: 10.1002/lary.25387
36
Li W, Chen Y, Sun ZP, et al. Clinicopathological characteristics of immunoglobulin G4-related sialadenitis[J]. Arthritis Res Ther, 2015, 17(1): 186.

doi: 10.1186/s13075-015-0698-y
37
Hong X, Zhang YY, Li W, et al. Treatment of immunoglobulin G4-related sialadenitis: Outcomes of glucocorticoid therapy combined with steroid-sparing agents[J]. Arthritis Res Ther, 2018, 20(1): 12.

doi: 10.1186/s13075-017-1507-6
38
俞光岩, 柳登高, 李巍, 等. 3类新型慢性唾液腺炎的诊断和治疗[J]. 北京大学学报(医学版), 2022, 54(1): 13- 17.
39
Singer MC, Marchal F, Angelos P, et al. Salivary and lacrimal dysfunction after radioactive iodine for differentiated thyroid cancer: American Head and Neck Society Endocrine Surgery Section and Salivary Gland Section joint multidisciplinary clinical consensus statement of otolaryngology, ophthalmology, nuclear medicine and endocrinology[J]. Head Neck, 2020, 42(11): 3446- 3459.

doi: 10.1002/hed.26417
40
李潇, 苏家增, 张严妍, 等. 131I相关唾液腺炎的炎症分级及内镜治疗[J]. 北京大学学报(医学版), 2020, 52(3): 586- 590.
41
Li X, Yang J, Qu LY, et al. Diagnosis and treatment of radioactive iodine-induced sialadenitis: A 10-year endoscopic experience[J]. Laryngoscope, 2024, 134(11): 4506- 4513.

doi: 10.1002/lary.31514
42
Baer AN, Okuhama A, Eisele DW, et al. Eosinophilic sialodochitis: Redefinition of 'allergic parotitis' and 'sialodochitis fibrinosa'[J]. Oral Dis, 2017, 23(7): 840- 848.

doi: 10.1111/odi.12595
43
Zhu WX, Chen Y, Liu DG, et al. Eosinophilic sialodochitis: A type of chronic obstructive sialadenitis related to allergy[J]. Laryngoscope, 2021, 131(3): E800- E806.
44
Du ZH, Ding C, Zhang Q, et al. Stem cells from exfoliated deciduous teeth alleviate hyposalivation caused by Sjögren syndrome[J]. Oral Dis, 2019, 25(6): 1530- 1544.

doi: 10.1111/odi.13113
45
Du Z, Wei P, Jiang N, et al. SHED-derived exosomes ameliorate hyposalivation caused by Sjögren's syndrome via Akt/GSK-3β/Slug-mediated ZO-1 expression[J]. Chin Med J, 2023, 136(21): 2596- 2608.

doi: 10.1097/CM9.0000000000002610
46
Chu WX, Ding C, Du ZH, et al. SHED-exos promote saliva secretion by suppressing p-ERK1/2-mediated apoptosis in glandular cells[J]. Oral Dis, 2024, 30(5): 3066- 3080.

doi: 10.1111/odi.14776
47
Du ZH, Chu WX, Peng X, et al. SHED-derived exosomes ameliorate Sjögren's syndrome induced hyposalivation by sup-pressing Th1 cell response via the miR-29a-3p/T-bet axis[J]. ACS Appl Mater Interfaces, 2025, 17(4): 5752- 5761.

doi: 10.1021/acsami.4c16595
48
Du Z, Feng L, Zhang Y, et al. Route of application and dose evaluation of dental pulp stem cells for the treatment of sialadenitis caused by Sjögren's syndrome: A preclinical study[J]. Biomedicines, 2025, 13(5): 1068.

doi: 10.3390/biomedicines13051068
49
俞光岩. 非肿瘤性唾液腺疾病的手术治疗[J]. 现代口腔医学杂志, 2011, 25(6): 401- 404.
50
俞光岩. 儿童唾液腺疾病[J]. 北京大学学报(医学版), 2024, 56(1): 1- 3.
51
Sun ZP, Hong X, Ma XC, et al. Cheek fistula from the ectopic salivary gland: A variant of the oculo-auriculo-vertebral spectrum[J]. Laryngoscope, 2015, 125(2): 360- 364.

doi: 10.1002/lary.24859
52
Wang Y, Yu GY, Huang MX, et al. Diagnosis and treatment of congenital dilatation of Stensen's duct[J]. Laryngoscope, 2011, 121(8): 1682- 1686.

doi: 10.1002/lary.21854
53
Zhu H, Yu GY. Lacrimo-auriculo-dento-digital syndrome with AIRE mutation: A case report[J]. J Stomatol Oral Maxillofac Surg, 2022, 123(6): e988- e990.

doi: 10.1016/j.jormas.2022.07.014
54
俞光岩, 宿骞, 张艳, 等. 唾液腺疾病与全身系统性疾病的相关性[J]. 北京大学学报(医学版), 2023, 55(1): 1- 7.
[1] 杨雨婷, 屈留洋, 郑丹妮, 凌晓彤, 许晓韵, 柳登高. 1 812例唾液腺结石患者的人口学特征和临床特点[J]. 北京大学学报（医学版）, 2026, 58(1): 153-159.
[2] 杨源源, 张珊珊, 俞光岩, 杨辉俊, 杨宏宇. 部分下颌下腺切除术治疗下颌下腺良性肿瘤的临床效果[J]. 北京大学学报（医学版）, 2025, 57(2): 334-339.
[3] 杨玉淑, 齐晅, 丁萌, 王炜, 郭惠芳, 高丽霞. 抗唾液腺蛋白1抗体联合抗腮腺分泌蛋白抗体对干燥综合征的诊断价值[J]. 北京大学学报（医学版）, 2024, 56(5): 845-852.
[4] 俞光岩. 儿童唾液腺疾病[J]. 北京大学学报（医学版）, 2024, 56(1): 1-3.
[5] 柳登高,郑丹妮,赵雅宁,张亚琼,叶欣,张丽琪,谢晓艳,张雷,张祖燕,俞光岩. 疑难唾液腺结石病的治疗研究[J]. 北京大学学报（医学版）, 2023, 55(1): 8-12.
[6] 俞光岩,宿骞,张艳,吴立玲. 唾液腺疾病与全身系统性疾病的相关性[J]. 北京大学学报（医学版）, 2023, 55(1): 1-7.
[7] 刘杨,程昉,王艳玲,艾香艳,朱振航,赵福涛. 唾液腺超声对干燥综合征的诊断价值[J]. 北京大学学报（医学版）, 2022, 54(6): 1123-1127.
[8] 俞光岩,苏家增,柳登高,吴立玲,丛馨. 下颌下腺保存治疗新技术体系的建立与应用[J]. 北京大学学报（医学版）, 2022, 54(5): 842-845.
[9] 俞光岩,柳登高,李巍,洪霞,张严妍,朱文瑄,张可夫,李潇,栗占国,刘燕鹰,陈艳,高岩,苏家增. 3类新型慢性唾液腺炎的诊断和治疗[J]. 北京大学学报（医学版）, 2022, 54(1): 13-17.
[10] 朱忆颖,闵赛南,俞光岩. 局部注射环孢素A对非肥胖糖尿病小鼠下颌下腺分泌功能及炎症的影响[J]. 北京大学学报（医学版）, 2021, 53(4): 750-757.
[11] 俞光岩. 多发性唾液腺肿大的鉴别诊断及处理[J]. 北京大学学报（医学版）, 2021, 53(1): 1-4.
[12] 李潇,苏家增,张严妍,张丽琪,张亚琼,柳登高,俞光岩. 131I相关唾液腺炎的炎症分级及内镜治疗[J]. 北京大学学报（医学版）, 2020, 52(3): 586-590.
[13] 张晔,张妮,刘晓筱,周传香. 唾液腺腺样囊性癌淋巴结转移相关的临床病理分析[J]. 北京大学学报（医学版）, 2020, 52(1): 30-34.
[14] 俞光岩,洪霞,李巍,张严妍,高岩,陈艳,张祖燕,谢晓艳,栗占国,刘燕鹰,苏家增,朱文瑄,孙志鹏. IgG4相关唾液腺炎的临床病理特点及诊断[J]. 北京大学学报（医学版）, 2019, 51(1): 1-3.
[15] 李巍, 孙志鹏, 刘筱菁, 俞光岩. 腮腺和颌下腺体积的测量[J]. 北京大学学报（医学版）, 2014, 46(2): 288-293.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
ISSN 1671-167X
CN 11-4691/R
主管单位：中华人民共和国教育部
主办单位：北京大学
地址： 北京市海淀区学院路38号 北京大学医学部 《北京大学学报（医学版）》
邮编：100191
电话：010-82801551
Email： xbbjb2@bjmu.edu.cn

《北京大学学报（医学版）》
微信公众号
版权所有 © 2018 《北京大学学报（医学版）》编辑部