北京大学学报(医学版) ›› 2009, Vol. 41 ›› Issue (4): 456-458.

• 技术方法 • 上一篇    下一篇

神经干细胞移植治疗遗传性小脑萎缩的临床研究(英文稿)

田增民1△,陈涛1,Nanbert ZHONG2,李志超1,尹丰1,刘爽1

  

  1. (1海军总医院全军神经外科中心, 北京100048; 2北京大学基础医学院医学遗传学系)
  • 收稿日期:2009-06-25 修回日期:1900-01-01 出版日期:2009-08-18 发布日期:2009-08-18
  • 通讯作者: 田增民

  • Received:2009-06-25 Revised:1900-01-01 Online:2009-08-18 Published:2009-08-18

摘要:

关键词: 橄榄体桥脑小脑萎缩, 干细胞移植, 治疗结果

Abstract: Objective: To study the clinical effect of neural stem cell transplantation in the treatment of inherited cerebellar atrophy (CA). Methods: The cells from human fetal cerebellum (8-10 weeks of gestation) were grown and expanded in vitro. The cultured neurospheres were then implanted into the dentate nuclei of patients by stereo tactic operation. Totally, 12 patients (7 males and 5 females with age ranging 22-62 years, mean 43 years) were treated by this operation from August 2006 to August 2008. Results: The cells of fetal cerebellum were expanded by 107 folds in undifferentiated state in the culture. After the operation, no rejection was detected. Follow up, the effective rates were 58.3% after 3 months, 75.0% after 6 months, and 66.7% for 12-24 months (mean 18 months). Conclusion: the transplantation of in vitro cultured neural stem cell is a feasible and effective treatment for inherited CA, but the long term effectiveness need to be taken in consideration.

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