北京大学学报(医学版) ›› 2020, Vol. 52 ›› Issue (3): 597-602. doi: 10.19723/j.issn.1671-167X.2020.03.031

• 短篇论著 • 上一篇    下一篇

中性粒细胞与淋巴细胞比例对评估接受过继性细胞免疫治疗的晚期胰腺癌患者预后的临床意义

姜妮,乔国梁,王小利,周心娜,周蕾,宋雨光,赵艳杰,任军()   

  1. 首都医科大学附属北京世纪坛医院肿瘤内科,肿瘤治疗性疫苗北京市重点实验室,北京 100038
  • 收稿日期:2018-11-12 出版日期:2020-06-18 发布日期:2020-06-30
  • 通讯作者: 任军 E-mail:renjun9688@yahoo.com

  • Received:2018-11-12 Online:2020-06-18 Published:2020-06-30

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关键词: 中性粒细胞, 淋巴细胞, 胰腺肿瘤, 免疫治疗, 预后

中图分类号: 

  • R730.51

表1

患者的基线特征"

Variable NLR>2.5
(n=18)
NLR≤2.5
(n=29)
P
Age/years, x?±s 68.0±11.0 66.3±11.2 0.244
Gender 0.731
Female 9 16
Male 9 13
ECOG-PS 0.529
1 7 14
2 11 15
TNM staging 0.238
2 5
16 24
Site of metastasis 0.178
Liver 5 14
Lung 4 5
Peritoneum 6 11
Others 6 10
Disease control 0.026
Stable 14 13
Progressive 4 16
CA-199 0.684
≥12 000 9 13
<12 000 9 16

图1

不同NLR组的总体生存率(A)和无进展生存期(B)"

图2

接受DC-CIK治疗患者不同NLR组的总体生存率(A)和无进展生存期(B),以及未接受DC-CIK治疗患者不同NLR组的总体生存率(C)和无进展生存期(D)"

表2

多因素Cox比例风险回归分析患者临床特征及生存"

Variables PFS OS
HR (95%CI) P value HR (95%CI) P value
ECOG-PS: 2 1.087 (0.716-1.358) 0.562 0.873 (0.761-1.132) 0.833
TNM staging: Ⅳ 1.003 (0.882-1.132) 0.638 0.944 (0.839-1.241) 0.793
NLR≤2.5 1.725 (1.448-3.103) 0.027 2.104 (1.582-4.372) 0.010
Infusion cycles 1.024 (0.899-1.219) 0.483 0.918 (0.721-1.149) 0.832
DC-CIK combined S-1 0.383 (0.127-0.639) 0.001 0.303 (0.147-0.659) 0.012

图3

第1周期DC-CIK治疗前后外周血T细胞表型"

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