北京大学学报(医学版) ›› 2022, Vol. 54 ›› Issue (2): 356-362. doi: 10.19723/j.issn.1671-167X.2022.02.025

• 论著 • 上一篇    下一篇

颧骨缺损不同修复重建方法和预后的回顾性分析

蓝璘,贺洋(),安金刚,张益   

  1. 北京大学口腔医学院·口腔医院口腔颌面外科,国家口腔医学中心,国家口腔疾病临床医学研究中心,口腔生物材料和数字诊疗装备国家工程研究中心,口腔数字医学北京市重点实验室,北京 100081
  • 收稿日期:2020-04-13 出版日期:2022-04-18 发布日期:2022-04-13
  • 通讯作者: 贺洋 E-mail:fridaydust1983@163.com
  • 基金资助:
    国家重点研发专项(2017YFB1104103)

Relationship between prognosis and different surgical treatments of zygomatic defects: A retrospective study

LAN Lin,HE Yang(),AN Jin-gang,ZHANG Yi   

  1. Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China
  • Received:2020-04-13 Online:2022-04-18 Published:2022-04-13
  • Contact: Yang HE E-mail:fridaydust1983@163.com
  • Supported by:
    National Key R&D Program of China(2017YFB1104103)

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摘要:

目的: 探讨颧骨缺损不同治疗方法的修复效果及特点。方法: 选择2012年8月至2019年8月于北京大学口腔医院口腔颌面外科就诊的颧骨缺损行修复重建的37例患者。根据颧骨缺损涉及的部位,将缺损分为四类:0类,缺损不涉及颧骨区段结构,仅为厚度(突度)变化;Ⅰ类,单个缺损位于颧骨体部或只涉及一个突起方向的缺损;Ⅱ类,单个缺损累及两个突起方向;Ⅲa类,单个缺损累及三个突起方向以上的缺损;Ⅲb类,颧骨缺损同时累及相应上颌骨的大范围缺损。统计分析各类颧骨缺损的病因、缺损时间、缺损大小及特点、采用的修复重建方式,并随访记录术后并发症等。术后CT评价颧骨突度及对称性恢复效果,进行色谱差值分析评价术后稳定效果。结果: 本组患者中,由创伤引起的颧骨缺损有25例(67.57%),肿瘤切除引起的颧骨缺损有11例(29.73%),另1例为骨发育畸形导致的颧骨缺损。19例患者行单纯自体骨移植修复,6例患者行血管化组织瓣修复,5例患者仅使用外植入物,另外7例患者使用血管化组织瓣联合外植入物修复。导航组和非导航组健、患侧颧骨突度差值中位数分别为0.45 mm(0.20~2.50 mm)和1.60 mm(0.10~2.90 mm),两组差值有统计学意义(P=0.045)。2例使用钛网结合股前外侧皮瓣修复的患者术后钛网发生明显变形或断裂,2例铸造个性化钛修复术后因感染而取出。结论: 对于无明显结构改变的颧骨缺损,可以用自体骨游离移植或异体材料修复。颧骨缺损存在骨支柱破坏、慢性炎症、口鼻腔相通或伴有明显软组织量不足时,建议带蒂颅骨骨膜瓣或血管化骨组织瓣修复。钛网可用于修复大量骨组织缺损的病例,同时建议联合血管化骨组织瓣移植修复。

关键词: 颧骨, 骨和骨组织, 修复外科手术, 预后

Abstract:

Objective: To evaluate the effect and summarize the characteristics of different treatment methods in repairing zygomatic defect. Methods: A total of 37 patients with zygomatic defect were reviewed in the Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology from August 2012 to August 2019. According to the anatomical scope of defect, the zygomatic defects were divided into four categories: Class 0, the defect did not involve changes in zygomatic structure or continuity, only deficiency in thickness or projection; Class Ⅰ, defect was located in the zygomatic body or involved only one process; Class Ⅱ, a single defect involved two processes; Class Ⅲa, referred to a single defect involving three processes and above; Class Ⅲb, referred to zygomatic defects associated with large maxillary defects. The etiology, defect time, defect size and characteristics of zygomatic defects, the repair and reconstruction methods, and postoperative complications were collected and analyzed. Postoperative computed tomography (CT) data were collected to evaluate the outcome of zygomatic protrusion. Chromatographic analysis was used to assess the postoperative stability. Results: Among the causes of defects, 25 cases (67.57%) were caused by trauma, and 11 cases (29.73%) were of surgical defects following tumor resection. We performed autologous bone grafts in 19 cases, 6 cases underwent vascularized tissue flap,5 cases underwent external implants alone, and 7 cases underwent vascularized tissue flap combined with external implants. After the recovery of the affected side, the average difference of the zygomatic projection between the navigation group and the non-navigation group was 0.45 mm (0.20-2.50 mm) and 1.60 mm (0.10-2.90 mm), with a significant difference (P=0.045). Two patients repaired with titanium mesh combined with anterolateral thigh flap had obvious deformation or fracture of titanium mesh; 2 patients with customized casting prosthesis had infection after surgery and fetched out the prosthesis finally. Conclusion: Autologous free grafts or alloplastic materials may be used in cases without significant structural changes. Pedicle skull flap or vascularized bone tissue flap is recommended for zygomatic bone defects with bone pillar destruction, chronic inflammation, oral and nasal communication or significant soft tissue insufficiency. Titanium mesh can be used to repair a large defect of zygomatic bone, and it is suggested to combine with vascularized bone flap transplantation.

Key words: Zygoma, Bone and bones, Reconstructive surgical procedures, Prognosis

中图分类号: 

  • R782.26

图1

颧骨缺损的分类"

图2

术后颧骨突度测量"

表1

不同颧骨缺损的基本信息"

Items 0 (n=1) Ⅰ (n=15) Ⅱ (n=7) Ⅲa (n=5) Ⅲb (n=9)
Gender
Male 0 14 5 4 6
Female 1 11 2 1 3
Age/years 22 44 (23-77) 41 (9-67) 31 (22-40) 36 (21-57)
Etiology
Skeletal dysplasia 1 0 0 0 0
Trauma 0 13 6 4 2
Tumor 0 2 1 1 7
CNTS
Yes 1 5 5 5 9
No 0 10 2 0 0

图3

部分常用的修复手术方式"

图4

铸造式个性化修复体"

图5

运用色谱及CT数据进行稳定性分析"

[1] Kokemueller H, Tavassol F, Rücker M, et al. Complex midfacial reconstruction: A combined technique of computer-assisted surgery and microvascular tissue transfer[J]. J Oral Maxillofac Surg, 2008, 66(11):2398-2406.
doi: 10.1016/j.joms.2007.12.030
[2] Zunz E, Blanc O, Leibovitch I. Traumatic orbital floor fractures: Repair with autogenous bone grafts in a tertiary trauma center[J]. J Oral Maxillofac Surg, 2012, 70(3):584-592.
doi: 10.1016/j.joms.2011.02.048
[3] 白萍, 刘和荣, 郝月军. Medpor在眼眶重建和眼球内陷复位手术中的应用[J]. 中国美容医学, 2004, 13(3):353-354.
[4] Butscher A, Bohner M, Hofmann S, et al. Structural and material approaches to bone tissue engineering in powder-based three-dimensional printing[J]. Acta Biomater, 2011, 7(3):907-920.
doi: 10.1016/j.actbio.2010.09.039 pmid: 20920616
[5] Pensler J, McCarthy JG. The calvarial donor site: An anatomic study in cadavers[J]. Plast Reconstr Surg, 1985, 75(5):648-651.
pmid: 3983272
[6] Markowitz NR. Cranial bone grafting in oral and maxillofacial surgery[J]. J Am Dent Assoc, 1992, 123(7):206-211.
pmid: 1619161
[7] Tatum SA, Kellman RM. Cranial bone grafting in maxillofacial trauma and reconstruction[J]. Facial Plast Surg, 1998, 14(1):117-129.
pmid: 10371899
[8] Kusiak JF, Zins JE, Whitaker LA. The early revascularization of membranous bone[J]. Plast Reconstr Surg, 1985, 76(4):510-516.
pmid: 4034769
[9] Rogers GF, Greene AK. Autogenous bone graft: Basic science and clinical implications[J]. J Craniofac Surg, 2012, 23(1):323-327.
doi: 10.1097/SCS.0b013e318241dcba pmid: 22337435
[10] Movahed R, Pinto LP, Morales-Ryan C, et al. Application of cranial bone grafts for reconstruction of maxillofacial deformities[J]. Proc (Bayl Univ Med Cent), 2013, 26(3):252-255.
doi: 10.1080/08998280.2013.11928973 pmid: 23814382
[11] Vandervord JG, Watson JD, Teasdale GM. Forehead reconstruction using a bi-pedicled bone flap[J]. Br J Plast Surg, 1982, 35(1):75-79.
pmid: 7066592
[12] He W, Gong X, He Y, et al. Application of a lateral pedicled cranial bone flap for the treatment of secondary zygomaticomaxillary defects[J]. J Craniofac Surg, 2019, 30(7):e661-e664.
doi: 10.1097/SCS.0000000000005776
[13] Gerressen M, Pastaschek CI, Riediger D, et al. Microsurgical free flap reconstructions of head and neck region in 406 cases: A 13-year experience[J]. J Oral Maxillofac Surg, 2013, 71(3):628-635.
doi: 10.1016/j.joms.2012.07.002
[14] Ghassemi A, Ghassemi M, Riediger D, et al. Comparison of donor-site engraftment after harvesting vascularized and nonvascularized iliac bone grafts[J]. J Oral Maxillofac Surg, 2009, 67(8):1589-1594.
doi: 10.1016/j.joms.2009.04.013
[15] Takano M, Sugahara K, Koyachi M, et al. Maxillary reconstruction using tunneling flap technique with 3D custom-made titanium mesh plate and particulate cancellous bone and marrow graft: A case report[J]. Maxillofac Plast Reconstr Surg, 2019, 41(1):43.
doi: 10.1186/s40902-019-0228-y
[16] Ghanaati S, Al-Maawi S, Conrad T, et al. Biomaterial-based bone regeneration and soft tissue management of the individualized 3D-titanium mesh: An alternative concept to autologous transplantation and flap mobilization[J]. J Craniomaxillofac Surg, 2019, 47(10):1633-1644.
doi: S1010-5182(19)30459-7 pmid: 31420282
[17] Zhang WB, Yu Y, Mao C, et al. Outcomes of zygomatic complex reconstruction with patient-specific titanium mesh using computer-assisted techniques[J]. J Oral Maxillofac Surg, 2019, 77(9):1915-1927.
doi: 10.1016/j.joms.2019.03.014
[18] Mischkowski RA, Selbach I, Neugebauer J, et al. Lateral femoral cutaneous nerve and iliac crest bone grafts:Anatomical and clinical considerations[J]. Int J Oral Maxillofac Surg, 2006, 35(4):366-372.
doi: 10.1016/j.ijom.2005.08.010
[19] Wei FC, Celik N, Yang WG, et al. Complications after reconstruction by plate and soft-tissue free flap in composite mandibular defects and secondary salvage reconstruction with osteocutaneous flap[J]. Plast Reconstr Surg, 2003, 112(1):37-42.
doi: 10.1097/01.PRS.0000065911.00623.BD
[20] Hidalgo DA, Pusic AL. Free-flap mandibular reconstruction: A 10-year follow-up study[J]. Plastic Reconstr Surg, 2002, 110(2):438-449.
doi: 10.1097/00006534-200208000-00010
[21] Nickels L. World’s first patient-specific jaw implant[J]. Metal Powder Report, 2012, 67(2):12-14.
[22] Macheras G, Kateros K, Kostakos A, et al. Eight- to ten-year clinical and radiographic outcome of a porous tantalum monoblock acetabular component[J]. J Arthroplasty, 2009, 24(5):705-709.
doi: 10.1016/j.arth.2008.06.020 pmid: 18703310
[23] Whitehouse MR, Masri BA, Duncan CP, et al. Continued good results with modular trabecular metal augments for acetabular defects in hip arthroplasty at 7 to 11 years[J]. Clin Orthop Relat Res, 2015, 473(2):521-527.
doi: 10.1007/s11999-014-3861-x
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