北京大学学报(医学版) ›› 2019, Vol. 51 ›› Issue (1): 35-42. doi: 10.19723/j.issn.1671-167X.2019.01.007
Qian SU1,Xin PENG1,Chuan-xiang ZHOU2,△(),Guang-yan YU1,△()
摘要:
目的: 探讨原发性腮腺淋巴瘤的临床病理特点及影响其预后的因素。方法: 收集2006—2016年于北京大学口腔医院口腔颌面外科就诊并诊断为原发性腮腺淋巴瘤患者的相关临床资料,结合复查随访资料,回顾性总结其临床病理特点及患者预后,分析影响预后的相关因素。结果:研究共纳入41例患者,中位年龄57岁(8个月至91岁),男 ∶女=1 ∶2.15,女性多见。40例(97.1%)为非霍奇金淋巴瘤(non-Hodgkin lymphoma,NHL),其中结外边缘区黏膜相关淋巴组织淋巴瘤(extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue,MALT)15例,弥漫性大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)14例,滤泡型淋巴瘤(follicular lymphoma,FL)4例,其他类型少见,霍奇金淋巴瘤(Hodgkin lymphoma,HL)仅占1例。Ann Arbor ⅠE~ⅡE期37例(90.2%),ⅢE~ⅣE期4例(9.8%)。7例(17.1%)淋巴瘤由干燥综合征恶变而来,均为MALT淋巴瘤。平均病期为20.7月,78%的患者以腮腺区缓慢生长的无痛性肿块为主要症状。治疗方法包括局部治疗及系统治疗,不同治疗方案均可取得较好疗效。全部患者均经5~149个月随访,其中9例(21.9%)死亡,2年总生存率为84.5%,5年总生存率为81.3%。单因素分析显示有无肿物加速生长史(P=0.005)和肿物有无包膜(P=0.011)为总生存率的影响因素,多因素分析显示肿物有无包膜(P=0.041)影响患者的总生存期。结论:腮腺淋巴瘤绝大多数为B细胞型NHL,MALT淋巴瘤与DLBCL最为常见,大部分患者表现为缓慢生长的腮腺区局限性肿块,临床上需与腮腺良性肿瘤相鉴别。干燥综合征与MALT淋巴瘤的发病密切相关。原发性腮腺淋巴瘤患者预后比其他恶性肿瘤相对较好,肿物无包膜提示预后较差。
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