乏氧诱导因子-1α在口腔鳞状细胞癌颈淋巴转移中的作用

doi:10.3969/j.issn.1671-167X.2018.01.005

北京大学学报(医学版) ›› 2018, Vol. 50 ›› Issue (1): 26-32. doi: 10.3969/j.issn.1671-167X.2018.01.005

乏氧诱导因子-1α在口腔鳞状细胞癌颈淋巴转移中的作用

李健男1，冯芝恩2，王琳3，王衣祥3，郭传瑸3△

（1. 北京大学口腔医学院·口腔医院，综合科口腔数字化医疗技术和材料国家工程实验室口腔数字医学北京市重点实验室，北京100081；2.首都医科大学附属北京口腔医院口腔颌面头颈肿瘤科，北京100050；3. 北京大学口腔医学院·口腔医院口腔颌面外科，北京100081）

出版日期:2018-02-18 发布日期:2018-02-18
通讯作者: 郭传瑸 E-mail:guodazuo@sina.com
基金资助:
国家自然科学基金（81470707）资助

Expression of hypoxiainducible factor 1α is associated with lymph node metastasis in oral squamous cell carcinoma

LI Jian-nan1, FENG Zhi-en2, WANG Lin3, WANG Yi-xiang3, GUO Chuan-bin3△

(1. Department of General Dentistry, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China; 2. Department of Oral and MaxillofacialHead and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, China; 3. Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China)

Online:2018-02-18 Published:2018-02-18
Contact: GUO Chuan-bin E-mail:guodazuo@sina.com
Supported by:
Supported by the National Natural Science Foundation of China (81470707)

摘要/Abstract

摘要： 目的：探讨乏氧诱导因子-1α（hypoxia-inducible factor 1α，HIF-1α）蛋白表达在口腔鳞状细胞癌颈淋巴转移中的作用及其在判断预后方面的意义。方法：1993年6月至2010年5月在北京大学口腔医院住院并接受手术治疗的原发口腔鳞状细胞癌患者125例纳入本次研究，收集所有患者的临床病理学资料，制作组织病理切片，应用免疫组织化学方法检测HIF-1α蛋白的表达情况，根据表达情况分为高表达组和低表达组，主要评估指标为颈淋巴转移率和癌相关生存率（disease-specific survival，DSS）。颈淋巴转移率与各项临床病理学参数的关系比较采用秩和检验，组间及组内癌相关生存率的差异性比较采用Kaplan-Meier分析，并应用COX多因素生存分析对DSS的独立预测因子进行统计分析。所有统计学分析均采用SPSS 17.0软件包完成。结果：随访截止日期为2013年6月1日，生存患者的中位随访时间为73个月，有75例HIF-1α高表达，48例HIF1α低表达，2例无法评估。秩和检验分析发现，HIF-1α高表达组淋巴转移率显著高于HIF-1α低表达组（58.7% vs. 37.5%，P=0.027）。Kaplan-Meier生存分析发现，HIF-1α低表达组患者无病生存率显著高于高表达组（60.4% vs. 36.0%，P=0.009），癌相关生存率显著高于高表达组（70.8% vs. 46.7%，P=0.005）。多因素生存分析表明，HIF-1α表达（HR=2.164，95%CI：1.150~4.074，P=0.017）和T分期（HR=1.387，95%CI：1.066~1.804，P=0.015）均是判断口腔鳞状细胞癌患者预后的独立预测因子。结论：HIF-1α蛋白表达是预测口腔鳞状细胞癌预后的独立因子，且与颈淋巴转移显著相关，能够作为口腔鳞状细胞癌潜在的分子诊断标志物和靶向治疗靶点。

关键词: 乏氧诱导因子1α, 癌, 鳞状细胞, 头颈部肿瘤, 淋巴转移, 预后

Abstract: Objective： To explore the association between hypoxia-inducible factor 1α (HIF-1α) expression and lymph node metastasis in oral squamous cell carcinoma (OSCC). Methods: Tumor specimens from 125 patients with histologically-proven, surgically-treated OSCC were examined by immunohistochemical staining for expression of HIF-1α. The patients were divided into two groups by the expression of HIF-1α, high expression of HIF-1α group (H-group) and low expression of HIF-1α group (L-group). The main assessment parameters were lymph node metastasis rate and disease-specific survival (DSS). The lymph node metastasis rate and clinicopathologic features were compared using Mann-Whitney test. The Kaplan-Meier curve was generated for each group and compared using the log-rank test. Cox proportional hazard models were utilized for multivariate analyses of HIF-1α expression and other baseline factors with DSS. All calculations and analyses were performed using the SPSS 17.0 software package. Results: The protein expression levels of HIF-1α were up-regulated in OSCC and two patients were unable to evaluate. There were 48 patients in L-group and 75 patients in H-group. Lymph node metastasis rate was 37.5% (18/48) for L-group and 58.7% (44/75) for H-group (P=0.027). Expression of HIF-1α was significantly correlated with lymph node metastasis. The patients of L-group had a significantly better DSS than the patients of Hgroup (70.8% vs. 46.7%, P=0.005), while the patients of L-group had a significantly better disease-free survival (DFS ) than the patients of H-group (60.4% vs. 36.0%, P=0.009) by Kaplan-Meier method. A multivariate survival analysis also showed that HIF-1α expression (HR=2.164, 95%CI: 1.150-4.074, P=0.017) and Tstage (HR=1.387, 95%CI: 1.066-1.804, P=0.015) both were the independent factors associated with prognosis. Conclusion: HIF-1α expression is significantly correlated with lymph node metastasis in OSCC. HIF-1α expression is an independent predictive factor for prognosis of OSCC patients, and may serve as a potential biomarker for molecular diagnosis and targeted therapy in future.

Key words: Hypoxia-inducible factor 1α, Carcinoma, squamous cell, Head and neck neoplasms, Lymphatic metastasis, Prognosis

中图分类号:

R739.8

李健男，冯芝恩，王琳，王衣祥，郭传瑸. 乏氧诱导因子-1α在口腔鳞状细胞癌颈淋巴转移中的作用[J]. 北京大学学报(医学版), 2018, 50(1): 26-32.

LI Jian-nan, FENG Zhi-en, WANG Lin, WANG Yi-xiang, GUO Chuan-bin. Expression of hypoxiainducible factor 1α is associated with lymph node metastasis in oral squamous cell carcinoma[J]. Journal of Peking University(Health Sciences), 2018, 50(1): 26-32.

参考文献

相关文章 15

[1]	黄教悌,胡菁,韩博. 治疗相关神经内分泌前列腺癌机制研究与靶向治疗新进展[J]. 北京大学学报（医学版）, 2024, 56(4): 557-561.
[2]	张树栋,谢睿扬. 机器人手术时代的肾癌合并腔静脉瘤栓治疗策略[J]. 北京大学学报（医学版）, 2024, 56(4): 562-564.
[3]	邢念增,王明帅,杨飞亚,尹路,韩苏军. 前列腺免活检创新理念的临床实践及其应用前景[J]. 北京大学学报（医学版）, 2024, 56(4): 565-566.
[4]	欧俊永,倪坤明,马潞林,王国良,颜野,杨斌,李庚午,宋昊东,陆敏,叶剑飞,张树栋. 肌层浸润性膀胱癌合并中高危前列腺癌患者的预后因素[J]. 北京大学学报（医学版）, 2024, 56(4): 582-588.
[5]	颜野,李小龙,夏海缀,朱学华,张羽婷,张帆,刘可,刘承,马潞林. 前列腺癌根治术后远期膀胱过度活动症的危险因素[J]. 北京大学学报（医学版）, 2024, 56(4): 589-593.
[6]	于书慧,韩佳凝,钟丽君,陈聪语,肖云翔,黄燕波,杨洋,车新艳. 术前盆底肌电生理参数对前列腺癌根治性切除术后早期尿失禁的预测价值[J]. 北京大学学报（医学版）, 2024, 56(4): 594-599.
[7]	刘帅,刘磊,刘茁,张帆,马潞林,田晓军,侯小飞,王国良,赵磊,张树栋. 伴静脉癌栓的肾上腺皮质癌的临床治疗及预后[J]. 北京大学学报（医学版）, 2024, 56(4): 624-630.
[8]	虞乐,邓绍晖,张帆,颜野,叶剑飞,张树栋. 具有低度恶性潜能的多房囊性肾肿瘤的临床病理特征及预后[J]. 北京大学学报（医学版）, 2024, 56(4): 661-666.
[9]	舒帆,郝一昌,张展奕,邓绍晖,张洪宪,刘磊,王国良,田晓军,赵磊,马潞林,张树栋. 肾部分切除术治疗囊性肾癌的功能学和肿瘤学结果：单中心回顾性研究[J]. 北京大学学报（医学版）, 2024, 56(4): 667-672.
[10]	周泽臻,邓绍晖,颜野,张帆,郝一昌,葛力源,张洪宪,王国良,张树栋. 非转移性T_3a肾细胞癌患者3年肿瘤特异性生存期预测[J]. 北京大学学报（医学版）, 2024, 56(4): 673-679.
[11]	方杨毅,李强,黄志高,陆敏,洪锴,张树栋. 睾丸鞘膜高分化乳头状间皮肿瘤1例[J]. 北京大学学报（医学版）, 2024, 56(4): 741-744.
[12]	曾媛媛,谢云,陈道南,王瑞兰. 脓毒症患者发生正常甲状腺性病态综合征的相关因素[J]. 北京大学学报（医学版）, 2024, 56(3): 526-532.
[13]	苏俊琪,王晓颖,孙志强. 舌鳞状细胞癌根治性切除术后患者预后预测列线图的构建与验证[J]. 北京大学学报（医学版）, 2024, 56(1): 120-130.
[14]	李建斌,吕梦娜,池强,彭一琳,刘鹏程,吴锐. 干燥综合征患者发生重症新型冠状病毒肺炎的早期预测[J]. 北京大学学报（医学版）, 2023, 55(6): 1007-1012.
[15]	刘耘充,吴宗龙,葛力源,杜坦,吴雅倩,宋一萌,刘承,马潞林. 肾透明细胞癌中核蛋白1对阿昔替尼耐药的作用及机制[J]. 北京大学学报（医学版）, 2023, 55(5): 781-792.

Metrics

Viewed

Full text

Abstract

Cited

Shared

Discussed

乏氧诱导因子-1α在口腔鳞状细胞癌颈淋巴转移中的作用

Expression of hypoxiainducible factor 1α is associated with lymph node metastasis in oral squamous cell carcinoma

RICH HTML

PDF (PC)

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

Metrics

本文评价

推荐阅读 0