牙周基础治疗对2型糖尿病伴慢性牙周炎患者红细胞、血小板相关指标的影响

doi:10.19723/j.issn.1671-167X.2020.04.029

北京大学学报（医学版） ›› 2020, Vol. 52 ›› Issue (4): 750-754. doi: 10.19723/j.issn.1671-167X.2020.04.029

牙周基础治疗对2型糖尿病伴慢性牙周炎患者红细胞、血小板相关指标的影响

郜洪宇^1,²,徐菁玲^1,^3*,孟焕新^1,^△(),和璐¹,侯建霞¹

1.北京大学口腔医学院·口腔医院,牙周科国家口腔疾病临床医学研究中心口腔数字化医疗技术和材料国家工程实验室口腔数字医学北京市重点实验室,北京 100081
2.天津医科大学口腔医院牙周科,天津 300070
3.北京大学第三医院口腔科,北京 100191

收稿日期:2020-02-21 出版日期:2020-08-18 发布日期:2020-08-06
通讯作者: 孟焕新 E-mail:kqhxmeng@bjmu.edu.cn
基金资助:
天津市教委科研计划项目(2016YD16)

Effect of initial periodontal therapy on blood parameters related to erythrocyte and platelet in patients with type 2 diabetes mellitus and chronic periodontitis

Hong-yu GAO^1,²,Jing-ling XU^1,^3*,Huan-xin MENG^1,^△(),Lu HE¹,Jian-xia HOU¹

1. Department of Periodontology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China
2. Department of Periodontology, School and Hospital of Stomatology, Tianjin Medical University, Tianjin 300070, China
3. Department of Stomatology, Peking University Third Hospital, Beijing 100191, China

Received:2020-02-21 Online:2020-08-18 Published:2020-08-06
Contact: Huan-xin MENG E-mail:kqhxmeng@bjmu.edu.cn
Supported by:
Science & Technology Development Fund of Tianjin Education Commission for Higher Education(2016YD16)

摘要/Abstract

摘要：

目的: 比较2型糖尿病伴慢性牙周炎(type 2 diabetes mellitus with chronic periodontitis,DM-P)患者牙周基础治疗前后的红细胞、血小板相关指标的水平。方法: 共纳入35例DM-P患者,所有参与者均进行牙周基础治疗,比较基线及治疗后3个月的牙周临床指标和红细胞、血小板指标。结果: 与基线时相比,DM-P患者牙周基础治疗后3个月的探诊深度[(3.370±0.601) mm vs. (2.729±0.431) mm]、出血指数[2.160 (1.550~3.410) vs. 1.420 (1.000~2.970)]、附着丧失[(3.307±1.577) mm vs. (2.990±1.587) mm]明显下降(P均<0.001),红细胞计数[(4.727±0.392)×10¹²/L vs. (4.825±0.394)×10¹²/L,P=0.010]、血红蛋白水平[(145.886±11.792) g/L vs. (149.200±12.979) g/L,P=0.007]、红细胞比容[43.40% (37.50%~48.50%) vs. 43.80% (38.50%~53.20%), P=0.003]显著增加,血小板计数[(216.714±61.900)×10⁹/L vs. (205.886±62.051)×10⁹/L,P=0.016]显著降低。结论: 牙周基础治疗显著改善DM-P患者的红细胞、血小板相关指标,可能降低DM-P患者发生糖尿病血管并发症的风险。

关键词: 糖尿病, 2型, 牙周炎, 红细胞, 血小板, 牙周基础治疗

Abstract:

Objective: To compare the blood parameters related to erythrocyte and platelet between baseline and 3 months after initial periodontal therapy in patients with both type 2 diabetes mellitus and chronic periodontitis (DM-P). Methods: According to the International Symposium on Classification of Periodontal Diseases and Conditions in 1999 and the diagnostic criteria of type 2 diabetes mellitus proposed by the World Health Organization in 1999, 35 patients with DM-P were recruited. All the participants received initial periodontal therapy, including oral hygiene instruction, scaling, and root planning provided by one senior periodontist. Original diet, exercise, and medication for blood glucose control were unchanged for all the participants. At baseline and 3 months after initial periodontal therapy, the clinical periodontal parameters, including probing depth (PD), bleeding index (BI) and clinical attachment loss (CAL); erythrocyte-related indexes, including red blood cell (RBC) count, hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), RBC volume distribution width (RDW); platelet-related indexes, including platelet (PLT) count, mean platelet volume (MPV), platelet distribution width (PDW), plateletocrit (PCT) were measured and compared. Results: Compared with baseline, the periodontal parameters, including PD [(3.370±0.601) mm vs. (2.729±0.431) mm], BI [2.160 (1.550~3.410) vs. 1.420 (1.000~2.970)] and CAL [(3.307±1.577) mm vs. (2.990±1.587) mm], were significantly reduced (P<0.001) three months after the initial periodontal therapy; the erythrocyte-related indexes, including RBC count [(4.727±0.392)×10¹²/L vs. (4.825±0.394)×10¹²/L, P=0.010], HGB [(145.886±11.792) g/L vs. (149.200±12.979) g/L, P=0.007] and HCT [43.40% (37.50%~48.50%) vs. 43.80% (38.50%~53.20%), P=0.003], were significantly increased three months after the initial periodontal therapy; PLT count [(216.714±61.900)×10⁹/L vs. (205.886±62.051)×10⁹/L, P=0.016] was significantly reduced 3 months after the initial periodontal therapy. Conclusion: The initial periodontal therapy can significantly improve blood parameters related to RBC and PLT, which might decrease the risk of vascular complications in DM-P patients.

Key words: Diabetes mellitus, type 2, Periodontitis, Erythrocytes, Blood platelets, Initial periodontal therapy

中图分类号:

R781.42

郜洪宇,徐菁玲,孟焕新,和璐,侯建霞. 牙周基础治疗对2型糖尿病伴慢性牙周炎患者红细胞、血小板相关指标的影响[J]. 北京大学学报（医学版）, 2020, 52(4): 750-754.

Hong-yu GAO,Jing-ling XU,Huan-xin MENG,Lu HE,Jian-xia HOU. Effect of initial periodontal therapy on blood parameters related to erythrocyte and platelet in patients with type 2 diabetes mellitus and chronic periodontitis[J]. Journal of Peking University (Health Sciences), 2020, 52(4): 750-754.

图/表 3

表1

表2

表3

牙周基础治疗对DM-P患者血小板相关指标的影响"

Platelet-related index	Baseline	3 months after therapy	P
PLT/(×10⁹/L), $x ?$ ±s	216.714±61.900	205.886±62.051	0.016
MPV/fL, $x ?$ ±s	10.757±1.488	11.017±1.356	0.202
PDW/fL, median (range)	13.40 (10.40-18.30)	13.40 (9.50-19.90)	0.521
PCT/%, $x ?$ ±s	23.343±6.049	22.429±6.568	0.296

表3

参考文献 25

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Erythrocyte-related index	Baseline	3 months after therapy	P
RBC/(×10¹²/L),$\bar{x}±s$	4.727±0.392	4.825±0.394	0.010
HGB/(g/L), $\bar{x}±s$	145.886±11.792	149.200±12.979	0.007
HCT/%, median (range)	43.40 (37.50-48.50)	43.80 (38.50-53.20)	0.003
MCV/fL, $\bar{x}±s$	91.574±3.374	92.134±3.299	0.133
MCH/pg, median (range)	30.90 (29.00-34.30)	30.80 (28.10-33.30)	0.644
MCHC/(g/L), $\bar{x}±s$	337.543±6.997	335.771±9.696	0.352
RDW_CV/%, median (range)	12.80 (11.90-14.40)	12.80 (11.80-13.90)	0.720

牙周基础治疗对2型糖尿病伴慢性牙周炎患者红细胞、血小板相关指标的影响

Effect of initial periodontal therapy on blood parameters related to erythrocyte and platelet in patients with type 2 diabetes mellitus and chronic periodontitis

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Periodontal clinical parameters	Baseline	3 months after therapy	P
PD/mm,$\bar{x}±s$	3.370±0.601	2.729±0.431	<0.001
BI, median (range)	2.160 (1.550-3.410)	1.420 (1.000-2.970)	<0.001
CAL/mm,$\bar{x}±s$	3.307±1.577	2.990±1.587	<0.001

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