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北京大学学报（医学版） ›› 2020, Vol. 52 ›› Issue (5): 919-923. doi: 10.19723/j.issn.1671-167X.2020.05.021

• 论著 • 上一篇    下一篇

125I粒子近距离治疗外放疗后复发唾液腺癌

于焕斌,伍文杰,吕晓鸣,石妍,郑磊,张建国()   

  1. 北京大学口腔医学院·口腔医院,口腔颌面外科 国家口腔疾病临床医学研究中心 口腔数字化医疗技术和材料国家工程实验室 口腔数字医学北京市重点实验室,北京 100081
  • 收稿日期:2018-09-27 出版日期:2020-10-18 发布日期:2020-10-15
  • 通讯作者: 张建国 E-mail:rszhang@126.com

125I seed brachytherapy for recurrent salivary gland carcinoma after external radiotherapy

Huan-bin YU,Wen-jie WU,Xiao-ming LV,Yan SHI,Lei ZHENG,Jian-guo ZHANG()   

  1. Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China
  • Received:2018-09-27 Online:2020-10-18 Published:2020-10-15
  • Contact: Jian-guo ZHANG E-mail:rszhang@126.com

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摘要：

目的:探讨 125I粒子近距离治疗外放疗后复发唾液腺癌的临床应用与疗效。方法:收集2004年7月至 2016年7月收治的43例接受外放疗或手术联合外放疗后头颈部唾液腺癌复发患者,按照头颈部癌常规分割放射治疗方案(每天1次,每次1.8~2.0 Gy,每周照射5 d)计算本组患者既往累积放射治疗剂量:7例患者50 Gy以下,26例患者50~60 Gy,4例患者60~70 Gy,6例患者80 Gy以上(80~120 Gy)。患者末次外放疗至局部复发时间间隔为4~204个月,中位时间间隔为48个月。43例患者中,25例单纯行125I粒子近距离治疗,18例行手术切除后125I粒子近距离治疗,近距离治疗的处方剂量为100~140 Gy。术后随访观察,统计局部控制率、生存率及无病生存率,评价毒副反应。结果:中位随访时间27个月(2.5~149.0个月),其中,腺样囊性癌患者中位随访时间31个月(2.5~112.0个月),黏液表皮样癌患者中位随访时间18个月(5~149个月)。1、3和5年局部控制率分别为66.5%、48.8%和42.7%,生存率分别为88.0%、56.7%和45.8%,无病生存率分别为58.3%、45.4%和38.1%。单纯粒子近距离治疗组与手术切除后粒子近距离治疗组在局部控制率、生存率和无病生存率上差异无统计学意义。急性放疗反应Ⅰ/Ⅱ级2例,Ⅲ级及以上3例;晚期放疗反应Ⅰ/Ⅱ级8例,Ⅲ级及以上3例;Ⅲ级及以上放疗反应发生率为7%。结论:125I粒子近距离治疗为治疗外放疗后复发唾液腺癌提供了可供选择的治疗方法,在毒副反应发生率较低的前提下提高了局部控制率和生存率。

关键词: 涎腺肿瘤, 肿瘤复发, 局部, 近距离放疗

Abstract:

Objective: To investigate the clinical application and efficacy of 125I radioactive seeds implantation in the treatment of recurrent salivary gland carcinoma after external radiotherapy. Methods: From July 2004 to July 2016, 43 cases of recurrent salivary gland carcinoma of the neck after external radiotherapy or surgery combined with external radiotherapy were treated. According to the conventional segmentation radiotherapy for head and neck cancer (once a day, 1.8-2.0 Gy each time, 5 days per week), the cumulative radiation dose of the patients in this group was calculated. In the study, 26 patients received 50-60 Gy, 7 patients received less than 50 Gy, 4 patients received 60-70 Gy, and 6 patients received more than 80 Gy (range: 80-120 Gy). The interval between the last external irradiation and local recurrence was 4-204 months, and the median interval was 48 months. Among them, 25 cases were treated with 125I radioactive seeds implantation only and 18 cases were treated with 125I radioactive seeds implantation after operation. The prescription dose was 100-140 Gy. The control rate, survival rate and disease-free survival rate were recorded to evaluate the side effects. Results: The median follow-up time was 27 months (ranging from 2.5 to 149.0 months). Among them, the median follow-up time of adenoid cystic carcinoma patients was 31 months (range: 2.5-112.0 months), and the median follow-up time of mucoepidermoid carcinoma patients was 18 months (range: 5-149 months). The local control rates for 1, 3 and 5 years were 66.5%, 48.8% and 42.7%, respectively. The 1-, 3- and 5- year survival rates were 88.0%, 56.7% and 45.8%, respectively. The disease-free survival rates of 1, 3 and 5 years were 58.3%, 45.4% and 38.1%, respectively. There was no statistically significant difference in local control rate, survival rate, and disease-free survival between the radioactive seeds implantation group and the radioactive seeds implantation group after surgical resection. There were 2 cases of acute radiation reaction Ⅰ/Ⅱ and 3 cases of reaction Ⅲ or above. In the late stage of radiotherapy, there were 8 cases with Ⅰ/Ⅱ grade reaction and 3 cases with Ⅲ grade or above reaction. The incidence of radiation reactions of Grade Ⅲ and above was 7%. Conclusion: 125I radioactive seeds implantation provides an alternative method for the treatment of recurrent salivary gland carcinoma after external radiotherapy. The local control rate and survival rate are improved on the premise of low incidence of side effects.

Key words: Salivary gland neoplasms, Neoplasm recurrence, local, Brachytherapy

中图分类号: 

  • R739.84

图1

局部控制率"

图2

两种治疗方式下的局部控制率"

图3

总生存率"

图4

两种治疗方式下的总生存率"

图5

无病生存率"

图6

两种治疗方式下的无病生存率"

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