北京大学学报(医学版) ›› 2014, Vol. 46 ›› Issue (2): 264-268.

• 论著 • 上一篇    下一篇

代谢综合征相关线粒体基因单核苷酸多态性与慢性牙周炎的关系

闫睿1, 栾庆先1△, 刘力笙2, 王兴宇2, 李蓬3, 沙月琴1   

  1. (1. 北京大学口腔医学院·口腔医院牙周科,北京100081; 2.北京市高血压联盟研究所人类基因实验室,北京100043; 3. 北京大学口腔医学院·口腔医院第二门诊部,北京100101)
  • 出版日期:2014-04-18 发布日期:2014-04-18

Association between chronic periodontitis and metabolic syndrome related mitochondria single nucleotide polymorphism

YAN Rui1, LUAN Qingxian1△, LIU Lisheng2, WANG Xingyu2, LI Peng3, SHA Yueqin1   

  1. (1. Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing 100081, China; 2.Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing 100043, China; 3.Second Clinical Division, Peking University School and Hospital of Stomatology, Beijing 100101,China)
  • Online:2014-04-18 Published:2014-04-18

摘要: 目的:检测227名北京市中老年人群的线粒体DNA(mitochondrial DNA, mtDNA)10398位点的单核苷酸多态性(single nucleotide polymorphism, SNP),探讨其与慢性牙周炎严重程度的关系。方法:227名北京市某社区居民于2005年接受了问卷调查、牙周检查和生化检查,以这些个体线粒体基因中特定片段DNA进行PCR扩增、测序,分析mtDNA 10398位点SNP与代谢综合征(metabolic syndrome,MS)及慢性牙周炎严重程度的关系。结果:在MS个体中,mtDNA 10398 G基因型明显高于非MS个体[80(70.2%) vs.34(29.8%), P=0.039],并且10398 G基因型的个体患MS的风险明显高于10398 A基因型(OR=1.77,95%CI=1.02~3.06, P=0.042),但是没有发现该基因SNP与牙周炎的严重程度有明显的相关性。结论:该社区人群mtDNA 10398 A→G SNP和MS有相关性,但与牙周炎的严重程度没有明显关系。

关键词: 代谢综合征, 牙周炎, DNA, 线粒体, 多态性, 单核苷酸

Abstract: Objective:To investigate the relationship between Mitochondrial DNA(mtDNA) SNP and the severity of periodontitis. Methods: In the study, 227 subjects in a community of Beijing received questionnaire interview, periodontal examination and biochemical laboratory examination in 2005. The designed primer was used to amplify the specific mtDNA fragments with PCR, and sequence the PCR products. Finally, the relationship between severity of chronic periodontitis and mtDNA SNP at site 10398 was analyzed. Results: The number of the subjects included at mtDNA site 10398 was 227. The G allele frequency in the metabolic syndrome(MS) subjects was significantly higher than that in the non MS subjects [80(70.2%) vs. 34(29.8%),P=0.039]. The result of Logistic regression showed that the subjects with G allele had higher risk of MS than the subjects with A allele(OR=1.77,95%CI=1.02-3.06, P=0.042). But there was no significant relationship between the 10398 A→G SNP and severity of periodontitis. Conclusion: In this population, mtDNA SNP 10398 A→G may be associated with MS. However, there was no relationship between the 10398 A→G SNP and severity of chronic periodontitis.

Key words: Metabolic syndrome, Periodontitis, DNA,mitochondria, Polymorphism, single nucleotide

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