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北京大学学报（医学版） ›› 2021, Vol. 53 ›› Issue (5): 928-932. doi: 10.19723/j.issn.1671-167X.2021.05.019

• 论著 • 上一篇    下一篇

肾细胞癌合并尿路瘤栓的临床病理特征: 6例报道及文献回顾

田雨1,程晓悦2,贺慧颖3,王国良1,△(),马潞林1   

  1. 1.北京大学第三医院泌尿外科,北京 100191
    2.首都医科大学附属北京友谊医院放射科,北京 100050
    3.北京大学第三医院病理科,北京 100191
  • 收稿日期:2021-04-06 出版日期:2021-10-18 发布日期:2021-10-11
  • 通讯作者: 王国良 E-mail:wangguoliang@medmail.com.cn

Clinical and pathological features of renal cell carcinoma with urinary tract tumor thrombus: 6 cases report and literature review

TIAN Yu1,CHENG Xiao-yue2,HE Hui-ying3,WANG Guo-liang1,△(),MA Lu-lin1   

  1. 1. Department of Urology, Peking University Third Hospital, Beijing 100191, China
    2. Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
    3. Department of Pathology, Peking University Third Hospital, Beijing 100191, China
  • Received:2021-04-06 Online:2021-10-18 Published:2021-10-11
  • Contact: Guo-liang WANG E-mail:wangguoliang@medmail.com.cn

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摘要：

目的: 探讨肾细胞癌合并尿路瘤栓的临床和病理特征。方法: 回顾性分析2015年1月1日至2019年12月31日在北京大学第三医院和首都医科大学附属北京友谊医院住院手术治疗肾细胞癌合并尿路瘤栓患者的基本信息、临床表现、治疗情况、病理特点和随访情况,同时检索文献,将既往报道的此类患者一并列为研究对象。结果: 本研究两家单位共收集到肾细胞癌合并尿路瘤栓患者6例,通过文献检索到16例,共计22例患者,其中男性13例,女性9例,平均年龄54.7岁(22~79岁);左肾15例,右肾6例,病变侧别不明1例;肉眼血尿是最常见的主诉(18例),体质量下降1例,镜下血尿1例,超声检查发现1例,就诊原因不明1例;瘤栓分级为Ⅰ级9例,Ⅱ级10例,Ⅲ级3例;术前诊断肾细胞癌的有11例,术前考虑肾盂癌或不能明确诊断者11例;行肾癌根治性切除术者9例,肾输尿管全长切除术者12例,1例手术方式不明;术后组织病理报告为透明细胞型肾细胞癌15例,乳头状肾细胞癌1例,嫌色细胞癌1例,混合细胞肾细胞癌1例,不能明确分型的肾细胞癌4例;11例患者有随访数据,随访3~31个月,有3例6个月内出现了肺转移。结论: 肾细胞癌合并尿路瘤栓临床上少见,在诊断上需与肾盂癌相鉴别,治疗原则可参照同类型肾细胞癌,对于局部进展期患者,手术完整切除是最佳的治疗方法,患者的肿瘤学预后还有待更长期和更大规模的随访观察。

关键词: 肾细胞癌, 尿路瘤栓, 肿瘤侵袭

Abstract:

Objective: To investigate the clinical characteristics, diagnosis and treatment of renal cell carcinoma with urinary tract tumor thrombus. Methods: From January 1, 2015 to December 31, 2019, patients with renal cell carcinoma complicated with urinary tract tumor thrombus who were hospitalized in the Peking University Third Hospital and Beijing Friendship Hospital, Capital Medical University were retrospectively analyzed. Meanwhile, we reviewed the literature, and the reported patients of renal cell carcinoma with urinary tract tumor thrombus were also included in our study. The basic information, clinical manifestations, treatment, pathological characteristics and follow-ups of all the patients were analyzed. Results: In our study, 6 patients from the two hospitals and 16 patients from previous literature reports were included. There were 13 males and 9 females with an average age of 54.7 years (22-79 years). Fifteen patients had renal cell carcinoma on the left side, 6 on the right side, and 1 on the unknown side. Gross hematuria was the most common chief complaint, including 18 patients. One patient complained of weight loss, 1 patient complained of microscopic hematuria, and 1 patient was found by ultrasound examination. Tumor thrombus was classified as grade Ⅰ in 9 cases (the tumor embolus protruded into the renal pelvis, but did not reach the ureteropelvic junction), grade Ⅱ in 10 cases (the tumor embolus protruded into the ureter, but not into the bladder), and grade Ⅲ in 3 cases (the tumor embolus passed through the ureter and protruded into the bladder). Only 11 patients were diagnosed with renal cell carcinoma before operation. Radical nephrectomy was performed in 9 cases and nephroureterectomy in 12 cases. In pathological diagnosis, there were 15 cases of clear cell renal cell carcinoma, 1 case of papillary renal cell carcinoma, 1 case of chromophobe cell carcinoma, 1 case of mixed cell renal cell carcinoma, 4 cases of renal cell carcinoma with undetermined classification. Eleven patients were followed up for 3-31 months, and 3 patients had lung metastasis within 6 months. Conclusion: Renal cell carcinoma with urinary tract tumor thrombus is rare in clinic. It needs to be differentiated from renal pelvis carcinoma in diagnosis. The treatment principle can refer to general renal carcinoma. For locally advanced cases, complete resection is the best treatment, and its oncological prognosis needs more long-term and large-scale follow-up observation.

Key words: Renal Cell Carcinoma, Urinary tract tumor thrombus, Neoplasm invasiveness

中图分类号: 

  • R737.11

表1

肾细胞癌合并尿路瘤栓患者的临床和病理信息*"

Case Gender Age/
years		 Chief
complaint		 Tumor
thrombus
classification		 Preoperative
diagnosis		 Operation
method		 Histological
diagnosis		 WHO/ISUP
grade		 Follow-up
1 Male 53 Gross
hematuria		 Ⅰ Right RCC Open right radical
nephrectomy		 Clear cell RCC Ⅱ No recurrence or
metastasis for 16 months
2 Female 50 Weight loss Ⅱ Left RCC Laparoscopic left
radical nephrectomy		 Clear cell RCC Ⅲ No recurrence or
metastasis for 20 months
3 Male 70 Gross
hematuria		 Ⅱ Right RCC/RPC Laparoscopic right
nephroureterectomy		 RCC NA No recurrence or
metastasis for 31 months
4 Male 64 Gross
hematuria		 Ⅰ Left RCC Laparoscopic left
radical nephrectomy		 Clear cell RCC Ⅱ-Ⅲ Bilateral pulmonary nodules
before operation and
survival after 16 months
5 Male 63 Gross
hematuria		 Ⅰ Left RPC Laparoscopic left
nephroureterectomy		 Clear cell RCC Ⅲ No recurrence or
metastasis for 24 months
6 Male 61 Gross
hematuria		 Ⅱ Right RCC Laparoscopic right
radical nephrectomy		 Clear cell RCC Ⅱ Lung metastasis after
6 months and
survival after 18 months
7[1] Male 22 Right abdominal
pain with gross
hematuria		 Ⅱ Right RPC Right
nephroureterectomy		 Mixed RCC NA NA
8[2] Female 62 NA Ⅰ RPC NA RCC NA NA
9[3] Male 67 Gross
hematuria		 Ⅲ Left RPC,
bladder tumor		 Cystoscopy biopsy;
Open left
nephroureterectomy		 Clear cell RCC Ⅲ NA
10[4] Male 43 Gross
hematuria		 Ⅱ Left RCC Laparoscopic left
nephroureterectomy		 Clear cell RCC Ⅱ-Ⅲ NA
11[5] Male 64 Gross
hematuria		 Ⅰ Left RCC, right
adrenal metastasis		 Laparoscopic left
radical nephrectomy
and right
adrenalectomy		 Clear cell RCC Ⅱ NA
12[5] Female 77 Gross
hematuria		 Ⅰ Right RCC Laparoscopic right
radical nephrectomy		 Clear cell RCC Ⅳ NA
13[6] Female 58 Ultrasound
examination		 Ⅰ Left RPC Laparoscopic left
nephroureterectomy		 Clear cell RCC NA NA
14[7] Female 51 microscopic
hematuria		 Ⅲ Left RPC Left nephroureterectomy Clear cell RCC Ⅰ-Ⅱ Lung metastasis
after 6 months
15[8] Male 51 Right back
pain with
gross hematuria		 Ⅱ Right RCC Right ureteroscopy biopsy;
Open right radical
nephrectomy		 RCC NA No recurrence or
metastasis for 9 months
16[9] Female 47 Gross
hematuria		 Ⅰ Left RCC Open left
nephroureterectomy		 Chromophobe
RCC		 NA NA
17[10] Female 63 Gross
hematuria		 Ⅱ Left RCC Left radical
nephrectomy		 Clear cell RCC NA NA
18[11] Female 27 Gross
hematuria		 Ⅱ Left RPC Open left
nephroureterectomy		 RCC Ⅲ No recurrence or
metastasis for 3 months
19[12] Male 66 Gross
hematuria		 Ⅲ Left RPC Open left
nephroureterectomy		 Clear cell RCC NA Lung metastasis
after 5 months
20[13] Female 39 Left back pain
with gross
hematuria		 Ⅱ Left RPC Left nephroureterectomy Clear cell RCC Ⅲ NA
21[14] Male 79 Gross hematuria Ⅱ Left RCC Robot-assisted laparoscopy
left radical nephrectomy		 Clear cell RCC Ⅳ NA
22[15] Male 27 Gross hematuria Ⅰ Right RPC Laparoscopic right
nephroureterectomy		 Papillary RCC,
type Ⅰ		 NA No recurrence or
metastasis for 6 months

图1

6例患者的CT检查(皮质期):病例1、2、4、6增强扫描皮质期呈不均匀显著强化,病例3、5皮质期病变强化程度低于肾实质"

图2

病例3右肾输尿管全长切除标本 图3 病例3组织病理学检查"

[1] Munechika H, Kushihashi T, Gokan T, et al. A renal cell carcinoma extending into the renal pelvis simulating transitional cell carcinoma [J]. Urol Radiol, 1990, 12(1):11-14.
pmid: 2333668
[2] Chen WC, Lee YH, Huang JK. Renal cell carcinoma with renal pelvic extension simulating transitional cell carcinoma: a case report [J]. Zhonghua Yi Xue Za Zhi, 1996, 58(2):147-150.
[3] Gulati M, Gore JL, Pantuek AJ, et al. Ureteral tumor thrombus from renal cell carcinoma extending into bladder [J]. Urol Oncol, 2007, 25(5):393-395.
doi: 10.1016/j.urolonc.2007.01.011
[4] Fujita O, Wada K, Yamasaki T, et al. Renal cell carcinoma with a tumor thrombus in the ureter: a case report [J]. BMC Urol, 2011, 11(16):1-5.
doi: 10.1186/1471-2490-11-1
[5] Kitazono MT, Coakley FV, Naeger DM, et al. CT of unusual renal masses invading the pelvicaliceal system: potential mimics of upper tract transitional cell carcinoma [J]. Clin Imaging, 2011, 35(1):77-80.
doi: 10.1016/j.clinimag.2010.02.012
[6] Jeong YB, Kim HJ. Is it transitional cell carcinoma or renal cell carcinoma on computed tomography image? [J]. Urology, 2012, 79(3):e42-e43.
doi: 10.1016/j.urology.2011.11.001
[7] Kakutani S, Kume H, Hirano Y, et al. Renal cell carcinoma with intraluminal spread of the entire upper urinary tract [J]. Case Rep Med, 2013, 2013:371387.
[8] Li Y, Ding YU, Chen D. Renal cell carcinoma growing into the renal pelvis and mimicking transitional cell carcinoma: A case report and literature review [J]. Oncol Lett, 2015, 9(4):1869-1872.
doi: 10.3892/ol.2015.2898
[9] 李嘉临, 纪志刚. 肾嫌色细胞癌侵入肾盂一例分析及文献复习 [J]. 国际外科学杂志, 2016, 43(9):625-627.
[10] Komatsubara M, Yamazaki M, Fujisaki A, et al. Tumor thrombus of renal cell carcinoma extending into the inferior vena cava, ova-rian vein, and ureter treated with neoadjuvant axitinib [J]. Urology, 2016, 95:e3-e4.
doi: 10.1016/j.urology.2016.05.057
[11] Parikesit D, Mochtar CA, Tanurahardja B, et al. Thrombus-like tumor of renal cell carcinoma mimicking transitional cell carcinoma of kidney: a case report [J]. Urol Case Rep, 2016, 10:26-29.
[12] Ishikawa T, Izumi K, Kondo T, et al. A case of renal cell carcinoma growing into the renal pelvis with a fibrin cap in the ureter and bladder [J]. Hinyokika Kiyo, 2018, 64(3):117-122.
doi: 10.14989/ActaUrolJap_64_3_117 pmid: 29684961
[13] Jeff J, Alessandro P. Clear cell renal cell carcinoma with a urete-ral thrombus [J]. J Endourol Case Rep, 2018, 4(1):159-162.
doi: 10.1089/cren.2018.0067 pmid: 30426074
[14] Bowman M, Reinstatler L, Pettus J, et al. An unusual case of renal cell carcinoma with tumor thrombosis of the proximal ureter [J]. Urol Case Rep, 2019, 23:60-61.
doi: 10.1016/j.eucr.2018.12.009 pmid: 30596019
[15] Kumar L, Jain S, Kaushal S, et al. A case of type 1 papillary renal cell cancer with pelvic tumor thrombus masquerading as urothelial cancer with review of literature [J]. J Endourol Case Rep, 2019, 5(4):157-160.
[16] Riehie JP. Carcinoma of the renal pelvis and ureter. Diagnosis and management of genitourinary cancer [M]. Philadelphia: Saunders, 1988: 323-336.
[17] National Cancer Institute. SEER Stat Fact Sheets: Kidney and renal pelvis cancer [EB/OL]. (2015-11-29) [2020-18-16]. http://seer.cancer.gov/statfacts/html/kidrp.html .
[18] 李松年. 中华影像医学: 泌尿生殖系统卷 [M]. 北京: 人民卫生出版社, 2002.
[19] Bata P, Tarnoki DL, Tarnoki AD, et al. Transitional cell and clear cell renal carcinoma: Differentiation of distinct histological types with multiphase CT [J]. Acta Radiol, 2014, 55(9):1112-1119.
doi: 10.1177/0284185113510493 pmid: 24243889
[20] Amin MB, Edge SB, Greene FL, et al. AJCC cancer staging manual [M]. 8th ed. New York: Springer, 2017.
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ISSN 1671-167X
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